FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044751729> ?p ?o ?g. }

• W3044751729 endingPage "103" @default.
• W3044751729 startingPage "95" @default.
• W3044751729 abstract "Enterovirus A71 (EV-A71) is one of the etiological pathogens leading to hand, foot, and mouth disease (HFMD), which can cause severe neurological complications. The neuropathogenesis of EV-A71 infection is not well understood. The mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43) is the pathological hallmark of amyotrophic lateral sclerosis (ALS). However, whether TDP-43 was impacted by EV-A71 infection is unknown. This study demonstrated that TDP-43 was cleaved during EV-A71 infection. The cleavage of TDP-43 requires EV-A71 replication rather than the activated caspases due to viral infection. TDP-43 is cleaved by viral protease 3C between the residues 331Q and 332S, while mutated TDP-43 (Q331A) was not cleaved. In addition, mutated 3C which lacks the protease activity failed to induce TDP-43 cleavage. We also found that TDP-43 was translocated from the nucleus to the cytoplasm, and the mislocalization of TDP-43 was induced by viral protease 2A rather than 3C. Taken together, we demonstrated that TDP-43 was cleaved by viral protease and translocated to the cytoplasm during EV-A71 infection, implicating the possible involvement of TDP-43 in the pathogenesis of EV-A71infection." @default.
• W3044751729 created "2020-07-29" @default.
• W3044751729 creator A5000970532 @default.
• W3044751729 creator A5001560666 @default.
• W3044751729 creator A5003642180 @default.
• W3044751729 creator A5011540763 @default.
• W3044751729 creator A5022925792 @default.
• W3044751729 creator A5029988853 @default.
• W3044751729 creator A5030259592 @default.
• W3044751729 creator A5033243059 @default.
• W3044751729 creator A5046857211 @default.
• W3044751729 creator A5051758194 @default.
• W3044751729 creator A5071902628 @default.
• W3044751729 date "2020-07-21" @default.
• W3044751729 modified "2023-10-17" @default.
• W3044751729 title "TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71" @default.
• W3044751729 cites W1930521170 @default.
• W3044751729 cites W1979179514 @default.
• W3044751729 cites W1980913885 @default.
• W3044751729 cites W1997720529 @default.
• W3044751729 cites W1998778692 @default.
• W3044751729 cites W2004775359 @default.
• W3044751729 cites W2010762066 @default.
• W3044751729 cites W2035954330 @default.
• W3044751729 cites W2053324095 @default.
• W3044751729 cites W2053987995 @default.
• W3044751729 cites W2060065563 @default.
• W3044751729 cites W2060076138 @default.
• W3044751729 cites W2077401865 @default.
• W3044751729 cites W2103119842 @default.
• W3044751729 cites W2111197922 @default.
• W3044751729 cites W2111528675 @default.
• W3044751729 cites W2122225964 @default.
• W3044751729 cites W2128175717 @default.
• W3044751729 cites W2128817844 @default.
• W3044751729 cites W2134734631 @default.
• W3044751729 cites W2144852254 @default.
• W3044751729 cites W2163279527 @default.
• W3044751729 cites W2166017239 @default.
• W3044751729 cites W2166499468 @default.
• W3044751729 cites W2169092675 @default.
• W3044751729 cites W2267870052 @default.
• W3044751729 cites W2276172330 @default.
• W3044751729 cites W2278953507 @default.
• W3044751729 cites W2299292241 @default.
• W3044751729 cites W2341346355 @default.
• W3044751729 cites W2422921762 @default.
• W3044751729 cites W2461563344 @default.
• W3044751729 cites W2492114245 @default.
• W3044751729 cites W2515789771 @default.
• W3044751729 cites W2536470745 @default.
• W3044751729 cites W2587239201 @default.
• W3044751729 cites W2602499836 @default.
• W3044751729 cites W2609669866 @default.
• W3044751729 cites W2612250648 @default.
• W3044751729 cites W2614705539 @default.
• W3044751729 cites W2625626754 @default.
• W3044751729 cites W2724567396 @default.
• W3044751729 cites W2763054784 @default.
• W3044751729 cites W2770800898 @default.
• W3044751729 cites W2910023123 @default.
• W3044751729 cites W2912670736 @default.
• W3044751729 cites W2922200433 @default.
• W3044751729 cites W2936004572 @default.
• W3044751729 cites W2954465031 @default.
• W3044751729 cites W2969364466 @default.
• W3044751729 cites W2980794614 @default.
• W3044751729 doi "https://doi.org/10.1007/s12250-020-00262-x" @default.
• W3044751729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7973337" @default.
• W3044751729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32696397" @default.
• W3044751729 hasPublicationYear "2020" @default.
• W3044751729 type Work @default.
• W3044751729 sameAs 3044751729 @default.
• W3044751729 citedByCount "6" @default.
• W3044751729 countsByYear W30447517292021 @default.
• W3044751729 countsByYear W30447517292022 @default.
• W3044751729 countsByYear W30447517292023 @default.
• W3044751729 crossrefType "journal-article" @default.
• W3044751729 hasAuthorship W3044751729A5000970532 @default.
• W3044751729 hasAuthorship W3044751729A5001560666 @default.
• W3044751729 hasAuthorship W3044751729A5003642180 @default.
• W3044751729 hasAuthorship W3044751729A5011540763 @default.
• W3044751729 hasAuthorship W3044751729A5022925792 @default.
• W3044751729 hasAuthorship W3044751729A5029988853 @default.
• W3044751729 hasAuthorship W3044751729A5030259592 @default.
• W3044751729 hasAuthorship W3044751729A5033243059 @default.
• W3044751729 hasAuthorship W3044751729A5046857211 @default.
• W3044751729 hasAuthorship W3044751729A5051758194 @default.
• W3044751729 hasAuthorship W3044751729A5071902628 @default.
• W3044751729 hasBestOaLocation W30447517292 @default.
• W3044751729 hasConcept C140704245 @default.
• W3044751729 hasConcept C142724271 @default.
• W3044751729 hasConcept C151730666 @default.
• W3044751729 hasConcept C153911025 @default.
• W3044751729 hasConcept C159047783 @default.
• W3044751729 hasConcept C175156509 @default.
• W3044751729 hasConcept C181199279 @default.
• W3044751729 hasConcept C185592680 @default.

• next