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- W3044762085 abstract "Single nucleotide polymorphism studies in the promoter region of TNFα (238) have suggested its role in increasedinsulin resistance and also in the progression from prediabetes to T2DM. It has been reported that genetic variations inthe promoter region regulate tumor necrosis factor-α (TNFα) production and transcription and, they influencesusceptibility to inflammatory related diseases. Impairment of normal functioning of the β‐cells of pancreatic islets is oneof the main causative factors for the suppression of insulin secretion. TNF‐α is among the main stimuli that induces theinflammation in pancreatic islets which leads to the induction of apoptosis in β‐cells of pancreatic islets. Transcriptionfactor 7 like 2 (TCF7L2) gene has been found to be one of the most risky genes for prediabetes and progressiontoT2DM. but, the underlying mechanism of this is still unknown. This is a review article demonstrated the possiblemechanisms of both TNFα G/A 238 and TCF7L2 C/T gene polymorphisms in prediabetes and Type 2Diabetes Mellitus." @default.
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- W3044762085 date "2020-01-01" @default.
- W3044762085 modified "2023-09-26" @default.
- W3044762085 title "THE BIOLOGICAL ROLE OF GENE POLYMORPHISMS: TNFΑ G/A ANDTCF7L2 IN TYPE 2 DIABETES." @default.
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