FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044762204> ?p ?o ?g. }

• W3044762204 endingPage "62" @default.
• W3044762204 startingPage "53" @default.
• W3044762204 abstract "Abstract Background Isocitrate dehydrogenase (IDH)–mutant tumors exhibit an altered metabolic state and are critically dependent upon nicotinamide adenine dinucleotide (NAD+) for cellular survival. NAD+ steady-state levels can be influenced by both biosynthetic and consumptive processes. Here, we investigated activation of sirtuin (SIRT) enzymes, which consume NAD+ as a coenzyme, as a potential mechanism to reduce cellular NAD+ levels in these tumors. Methods The effect of inhibition or activation of sirtuin activity, using (i) small molecules, (ii) clustered regularly interspaced short palindromic repeat/CRISPR associated protein 9 gene editing, and (iii) inducible overexpression, was investigated in IDH-mutant tumor lines, including patient-derived IDH-mutant glioma lines. Results We found that Sirt1 activation led to marked augmentation of NAD+ depletion and accentuation of cytotoxicity when combined with inhibition of nicotinamide phosphoribosyltransferase (NAMPT), consistent with the enzymatic activity of SIRT1 as a primary cellular NAD+ consumer in IDH-mutant cells. Activation of Sirt1 through either genetic overexpression or pharmacologic Sirt1-activating compounds (STACs), an existing class of well-tolerated drugs, led to inhibition of IDH1-mutant tumor cell growth. Conclusions Activation of Sirt1 can selectively target IDH-mutant tumors. These findings indicate that relatively nontoxic STACs, administered either alone or in combination with NAMPT inhibition, could alter the growth trajectory of IDH-mutant gliomas while minimizing toxicity associated with cytotoxic chemotherapeutic regimens." @default.
• W3044762204 created "2020-07-29" @default.
• W3044762204 creator A5006633218 @default.
• W3044762204 creator A5012391141 @default.
• W3044762204 creator A5013776345 @default.
• W3044762204 creator A5014614164 @default.
• W3044762204 creator A5016767559 @default.
• W3044762204 creator A5030340096 @default.
• W3044762204 creator A5052279889 @default.
• W3044762204 creator A5070370541 @default.
• W3044762204 creator A5078203308 @default.
• W3044762204 creator A5088348731 @default.
• W3044762204 creator A5089487660 @default.
• W3044762204 date "2020-07-26" @default.
• W3044762204 modified "2023-10-15" @default.
• W3044762204 title "Sirtuin activation targets IDH-mutant tumors" @default.
• W3044762204 cites W1736016875 @default.
• W3044762204 cites W1812256879 @default.
• W3044762204 cites W1968890500 @default.
• W3044762204 cites W1972205860 @default.
• W3044762204 cites W1985075679 @default.
• W3044762204 cites W1985802000 @default.
• W3044762204 cites W1989674299 @default.
• W3044762204 cites W2011376261 @default.
• W3044762204 cites W2015755329 @default.
• W3044762204 cites W2018041848 @default.
• W3044762204 cites W2033401394 @default.
• W3044762204 cites W2040827479 @default.
• W3044762204 cites W2045493291 @default.
• W3044762204 cites W2075793755 @default.
• W3044762204 cites W2076552336 @default.
• W3044762204 cites W2078972833 @default.
• W3044762204 cites W2080452140 @default.
• W3044762204 cites W2096796171 @default.
• W3044762204 cites W2097948853 @default.
• W3044762204 cites W2100795816 @default.
• W3044762204 cites W2101246344 @default.
• W3044762204 cites W2114132465 @default.
• W3044762204 cites W2115276344 @default.
• W3044762204 cites W2118964113 @default.
• W3044762204 cites W2119976307 @default.
• W3044762204 cites W2124595934 @default.
• W3044762204 cites W2126817554 @default.
• W3044762204 cites W2126820971 @default.
• W3044762204 cites W2131860315 @default.
• W3044762204 cites W2134061682 @default.
• W3044762204 cites W2137361994 @default.
• W3044762204 cites W2155800445 @default.
• W3044762204 cites W2160700740 @default.
• W3044762204 cites W2166138133 @default.
• W3044762204 cites W2166529463 @default.
• W3044762204 cites W2168784615 @default.
• W3044762204 cites W2171026968 @default.
• W3044762204 cites W2192221936 @default.
• W3044762204 cites W2432789362 @default.
• W3044762204 cites W2560255046 @default.
• W3044762204 cites W2597755234 @default.
• W3044762204 cites W2623089849 @default.
• W3044762204 cites W2625742115 @default.
• W3044762204 cites W2767704967 @default.
• W3044762204 cites W2803357178 @default.
• W3044762204 cites W2806682325 @default.
• W3044762204 cites W2887976258 @default.
• W3044762204 cites W2890911268 @default.
• W3044762204 cites W2911619657 @default.
• W3044762204 cites W2941157636 @default.
• W3044762204 cites W571060166 @default.
• W3044762204 doi "https://doi.org/10.1093/neuonc/noaa180" @default.
• W3044762204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7850026" @default.
• W3044762204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32710757" @default.
• W3044762204 hasPublicationYear "2020" @default.
• W3044762204 type Work @default.
• W3044762204 sameAs 3044762204 @default.
• W3044762204 citedByCount "14" @default.
• W3044762204 countsByYear W30447622042020 @default.
• W3044762204 countsByYear W30447622042021 @default.
• W3044762204 countsByYear W30447622042022 @default.
• W3044762204 countsByYear W30447622042023 @default.
• W3044762204 crossrefType "journal-article" @default.
• W3044762204 hasAuthorship W3044762204A5006633218 @default.
• W3044762204 hasAuthorship W3044762204A5012391141 @default.
• W3044762204 hasAuthorship W3044762204A5013776345 @default.
• W3044762204 hasAuthorship W3044762204A5014614164 @default.
• W3044762204 hasAuthorship W3044762204A5016767559 @default.
• W3044762204 hasAuthorship W3044762204A5030340096 @default.
• W3044762204 hasAuthorship W3044762204A5052279889 @default.
• W3044762204 hasAuthorship W3044762204A5070370541 @default.
• W3044762204 hasAuthorship W3044762204A5078203308 @default.
• W3044762204 hasAuthorship W3044762204A5088348731 @default.
• W3044762204 hasAuthorship W3044762204A5089487660 @default.
• W3044762204 hasBestOaLocation W30447622041 @default.
• W3044762204 hasConcept C104317684 @default.
• W3044762204 hasConcept C127561419 @default.
• W3044762204 hasConcept C127848430 @default.
• W3044762204 hasConcept C143065580 @default.
• W3044762204 hasConcept C153911025 @default.
• W3044762204 hasConcept C181199279 @default.
• W3044762204 hasConcept C185592680 @default.

• next