FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044765662> ?p ?o ?g. }

• W3044765662 endingPage "1760" @default.
• W3044765662 startingPage "1760" @default.
• W3044765662 abstract "Resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis represents the major hurdle to the clinical use of TRAIL or its derivatives. The discovery and development of lead compounds able to sensitize tumor cells to TRAIL-induced cell death is thus likely to overcome this limitation. We recently reported that marine actinomycetes’ crude extracts could restore TRAIL sensitivity of the MDA-MB-231 resistant triple negative breast cancer cell line. We demonstrate in this study, that purified secondary metabolites originating from distinct marine actinomycetes (sharkquinone (1), resistomycin (2), undecylprodigiosin (3), butylcyclopentylprodigiosin (4), elloxizanone A (5) and B (6), carboxyexfoliazone (7), and exfoliazone (8)), alone, and in a concentration-dependent manner, induce killing in both MDA-MB-231 and HCT116 cell lines. Combined with TRAIL, these compounds displayed additive to synergistic apoptotic activity in the Jurkat, HCT116 and MDA-MB-231 cell lines. Mechanistically, these secondary metabolites induced and enhanced procaspase-10, -8, -9 and -3 activation leading to an increase in PARP and lamin A/C cleavage. Apoptosis induced by these compounds was blocked by the pan-caspase inhibitor QvD, but not by a deficiency in caspase-8, FADD or TRAIL agonist receptors. Activation of the intrinsic pathway, on the other hand, is likely to explain both their ability to trigger cell death and to restore sensitivity to TRAIL, as it was evidenced that these compounds could induce the downregulation of XIAP and survivin. Our data further highlight that compounds derived from marine sources may lead to novel anti-cancer drug discovery." @default.
• W3044765662 created "2020-07-29" @default.
• W3044765662 creator A5000815783 @default.
• W3044765662 creator A5005280647 @default.
• W3044765662 creator A5014002400 @default.
• W3044765662 creator A5032996061 @default.
• W3044765662 creator A5033900987 @default.
• W3044765662 creator A5065935848 @default.
• W3044765662 date "2020-07-22" @default.
• W3044765662 modified "2023-10-15" @default.
• W3044765662 title "Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP" @default.
• W3044765662 cites W1484817497 @default.
• W3044765662 cites W1520292475 @default.
• W3044765662 cites W1604468403 @default.
• W3044765662 cites W1873008523 @default.
• W3044765662 cites W1963506577 @default.
• W3044765662 cites W1968844315 @default.
• W3044765662 cites W1969107308 @default.
• W3044765662 cites W1970935314 @default.
• W3044765662 cites W1974995883 @default.
• W3044765662 cites W1977011528 @default.
• W3044765662 cites W1979145183 @default.
• W3044765662 cites W1982017897 @default.
• W3044765662 cites W1982350795 @default.
• W3044765662 cites W1983284232 @default.
• W3044765662 cites W1985089556 @default.
• W3044765662 cites W1986038186 @default.
• W3044765662 cites W1986728007 @default.
• W3044765662 cites W1991736560 @default.
• W3044765662 cites W1992952650 @default.
• W3044765662 cites W1994990166 @default.
• W3044765662 cites W1996621261 @default.
• W3044765662 cites W2004457956 @default.
• W3044765662 cites W2007718868 @default.
• W3044765662 cites W2009146433 @default.
• W3044765662 cites W2017444142 @default.
• W3044765662 cites W2018017071 @default.
• W3044765662 cites W2019249970 @default.
• W3044765662 cites W2020439083 @default.
• W3044765662 cites W2022452916 @default.
• W3044765662 cites W2025749480 @default.
• W3044765662 cites W2025988505 @default.
• W3044765662 cites W2026057304 @default.
• W3044765662 cites W2036111708 @default.
• W3044765662 cites W2047271635 @default.
• W3044765662 cites W2060072994 @default.
• W3044765662 cites W2069266155 @default.
• W3044765662 cites W2074584594 @default.
• W3044765662 cites W2075882509 @default.
• W3044765662 cites W2076044966 @default.
• W3044765662 cites W2078415854 @default.
• W3044765662 cites W2079931526 @default.
• W3044765662 cites W2080761304 @default.
• W3044765662 cites W2094302689 @default.
• W3044765662 cites W2094570524 @default.
• W3044765662 cites W2106284224 @default.
• W3044765662 cites W2107377459 @default.
• W3044765662 cites W2116462993 @default.
• W3044765662 cites W2117132135 @default.
• W3044765662 cites W2117476538 @default.
• W3044765662 cites W2117692326 @default.
• W3044765662 cites W2117960631 @default.
• W3044765662 cites W2129305290 @default.
• W3044765662 cites W2134454138 @default.
• W3044765662 cites W2148019984 @default.
• W3044765662 cites W2167049000 @default.
• W3044765662 cites W2174794074 @default.
• W3044765662 cites W2176380383 @default.
• W3044765662 cites W2214639019 @default.
• W3044765662 cites W2341398279 @default.
• W3044765662 cites W2405271886 @default.
• W3044765662 cites W2406655698 @default.
• W3044765662 cites W2441234952 @default.
• W3044765662 cites W2509845469 @default.
• W3044765662 cites W2520346512 @default.
• W3044765662 cites W2563040416 @default.
• W3044765662 cites W2604506697 @default.
• W3044765662 cites W2607207351 @default.
• W3044765662 cites W2614029138 @default.
• W3044765662 cites W2624316269 @default.
• W3044765662 cites W2790833438 @default.
• W3044765662 cites W2807345056 @default.
• W3044765662 cites W2898531023 @default.
• W3044765662 cites W2931826519 @default.
• W3044765662 cites W2950050303 @default.
• W3044765662 cites W2951276669 @default.
• W3044765662 cites W4230081979 @default.
• W3044765662 doi "https://doi.org/10.3390/cells9081760" @default.
• W3044765662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7464567" @default.
• W3044765662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32708048" @default.
• W3044765662 hasPublicationYear "2020" @default.
• W3044765662 type Work @default.
• W3044765662 sameAs 3044765662 @default.
• W3044765662 citedByCount "16" @default.
• W3044765662 countsByYear W30447656622020 @default.
• W3044765662 countsByYear W30447656622021 @default.
• W3044765662 countsByYear W30447656622022 @default.
• W3044765662 countsByYear W30447656622023 @default.

• next