FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044770175> ?p ?o ?g. }

• W3044770175 endingPage "144.e6" @default.
• W3044770175 startingPage "131" @default.
• W3044770175 abstract "We present a combinatorial machine learning method to evaluate and optimize peptide vaccine formulations for SARS-CoV-2. Our approach optimizes the presentation likelihood of a diverse set of vaccine peptides conditioned on a target human-population HLA haplotype distribution and expected epitope drift. Our proposed SARS-CoV-2 MHC class I vaccine formulations provide 93.21% predicted population coverage with at least five vaccine peptide-HLA average hits per person (≥ 1 peptide: 99.91%) with all vaccine peptides perfectly conserved across 4,690 geographically sampled SARS-CoV-2 genomes. Our proposed MHC class II vaccine formulations provide 97.21% predicted coverage with at least five vaccine peptide-HLA average hits per person with all peptides having an observed mutation probability of ≤ 0.001. We provide an open-source implementation of our design methods (OptiVax), vaccine evaluation tool (EvalVax), as well as the data used in our design efforts here: https://github.com/gifford-lab/optivax." @default.
• W3044770175 created "2020-07-29" @default.
• W3044770175 creator A5018324670 @default.
• W3044770175 creator A5041788509 @default.
• W3044770175 creator A5055979952 @default.
• W3044770175 creator A5076758822 @default.
• W3044770175 creator A5082442738 @default.
• W3044770175 creator A5083219751 @default.
• W3044770175 creator A5090423795 @default.
• W3044770175 date "2020-08-01" @default.
• W3044770175 modified "2023-10-06" @default.
• W3044770175 title "Computationally Optimized SARS-CoV-2 MHC Class I and II Vaccine Formulations Predicted to Target Human Haplotype Distributions" @default.
• W3044770175 cites W1503364994 @default.
• W3044770175 cites W1675195038 @default.
• W3044770175 cites W2000251753 @default.
• W3044770175 cites W2020564539 @default.
• W3044770175 cites W2043098712 @default.
• W3044770175 cites W2077312152 @default.
• W3044770175 cites W2125732073 @default.
• W3044770175 cites W2141059167 @default.
• W3044770175 cites W2166808662 @default.
• W3044770175 cites W2267653167 @default.
• W3044770175 cites W2587970647 @default.
• W3044770175 cites W2743893844 @default.
• W3044770175 cites W2783102765 @default.
• W3044770175 cites W2912018962 @default.
• W3044770175 cites W2948058491 @default.
• W3044770175 cites W2952045272 @default.
• W3044770175 cites W2953065444 @default.
• W3044770175 cites W3005011674 @default.
• W3044770175 cites W3005409321 @default.
• W3044770175 cites W3005844923 @default.
• W3044770175 cites W3007407747 @default.
• W3044770175 cites W3007643904 @default.
• W3044770175 cites W3007708817 @default.
• W3044770175 cites W3007886991 @default.
• W3044770175 cites W3009335299 @default.
• W3044770175 cites W3011488280 @default.
• W3044770175 cites W3011701533 @default.
• W3044770175 cites W3016853422 @default.
• W3044770175 cites W3020089922 @default.
• W3044770175 cites W3024570138 @default.
• W3044770175 cites W3025320502 @default.
• W3044770175 cites W3034130789 @default.
• W3044770175 cites W3136918052 @default.
• W3044770175 doi "https://doi.org/10.1016/j.cels.2020.06.009" @default.
• W3044770175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7384425" @default.
• W3044770175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32721383" @default.
• W3044770175 hasPublicationYear "2020" @default.
• W3044770175 type Work @default.
• W3044770175 sameAs 3044770175 @default.
• W3044770175 citedByCount "46" @default.
• W3044770175 countsByYear W30447701752020 @default.
• W3044770175 countsByYear W30447701752021 @default.
• W3044770175 countsByYear W30447701752022 @default.
• W3044770175 countsByYear W30447701752023 @default.
• W3044770175 crossrefType "journal-article" @default.
• W3044770175 hasAuthorship W3044770175A5018324670 @default.
• W3044770175 hasAuthorship W3044770175A5041788509 @default.
• W3044770175 hasAuthorship W3044770175A5055979952 @default.
• W3044770175 hasAuthorship W3044770175A5076758822 @default.
• W3044770175 hasAuthorship W3044770175A5082442738 @default.
• W3044770175 hasAuthorship W3044770175A5083219751 @default.
• W3044770175 hasAuthorship W3044770175A5090423795 @default.
• W3044770175 hasBestOaLocation W30447701751 @default.
• W3044770175 hasConcept C104317684 @default.
• W3044770175 hasConcept C135763542 @default.
• W3044770175 hasConcept C147483822 @default.
• W3044770175 hasConcept C159047783 @default.
• W3044770175 hasConcept C170627219 @default.
• W3044770175 hasConcept C188280979 @default.
• W3044770175 hasConcept C195616568 @default.
• W3044770175 hasConcept C197754878 @default.
• W3044770175 hasConcept C207936829 @default.
• W3044770175 hasConcept C2776789287 @default.
• W3044770175 hasConcept C2908647359 @default.
• W3044770175 hasConcept C41008148 @default.
• W3044770175 hasConcept C54355233 @default.
• W3044770175 hasConcept C70721500 @default.
• W3044770175 hasConcept C71924100 @default.
• W3044770175 hasConcept C86803240 @default.
• W3044770175 hasConcept C99454951 @default.
• W3044770175 hasConceptScore W3044770175C104317684 @default.
• W3044770175 hasConceptScore W3044770175C135763542 @default.
• W3044770175 hasConceptScore W3044770175C147483822 @default.
• W3044770175 hasConceptScore W3044770175C159047783 @default.
• W3044770175 hasConceptScore W3044770175C170627219 @default.
• W3044770175 hasConceptScore W3044770175C188280979 @default.
• W3044770175 hasConceptScore W3044770175C195616568 @default.
• W3044770175 hasConceptScore W3044770175C197754878 @default.
• W3044770175 hasConceptScore W3044770175C207936829 @default.
• W3044770175 hasConceptScore W3044770175C2776789287 @default.
• W3044770175 hasConceptScore W3044770175C2908647359 @default.
• W3044770175 hasConceptScore W3044770175C41008148 @default.
• W3044770175 hasConceptScore W3044770175C54355233 @default.
• W3044770175 hasConceptScore W3044770175C70721500 @default.
• W3044770175 hasConceptScore W3044770175C71924100 @default.
• W3044770175 hasConceptScore W3044770175C86803240 @default.

• next