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- W3044771108 abstract "Abstract Recently, photochromic derivatives of nucleobases have drawn attention for regulating oligonucleotide hybridization with light for photopharmacological applications. The nucleobase moiety provides attractive interaction for hybridization, whereas the photochromic moiety can alter the interaction upon irradiation due to conformational changes. Herein we report the synthesis of 2‐phenyldiazenyl‐substituted 2’‐deoxyadenosine ( dA Azo ) and 2’‐deoxyguanosine ( dG Azo ) and investigate their influence in a DNA context by UV/Vis absorption, fluorescence and CD spectroscopies. For comparison, the literature‐known azobenzene C ‐nucleoside DNAzo was used as a reference system. It could be shown that photochromic purines improve overall hybridization affinity compared to azobenzene C ‐nucleosides. In particular, 2’‐deoxyadenosine analogue dA Azo increases melting temperatures by 7.5 °C in the favored trans state with 86 % of the switching efficiency of the reference system." @default.
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- W3044771108 date "2020-08-07" @default.
- W3044771108 modified "2023-09-26" @default.
- W3044771108 title "Photoswitchable 2‐Phenyldiazenyl‐Purines and their Influence on DNA Hybridization" @default.
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- W3044771108 doi "https://doi.org/10.1002/cptc.202000162" @default.
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