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- W3044821644 abstract "The current work reports the synthesized and biological evaluation of 6-methoxy-2-amino benzothiazole (A1), which was prepared via reaction p-Ansidine with ammonium thiocyanate followed by the oxidative ring closure of the resultant thiourea with a catalytic amount of bromine, in the alkaline medium. The resulting compound(A1) underwent condensation reactions with various kinds of aldehydes to produce Hydrazones (A3a- d). 6-methoxy2-hydrazinobenzothiazole (A2) was prepared through the reaction of the compound (A1) with 99.9 % hydrazine hydrate in the presence of concentrated HCl and ethylene glycol solution. After that, the compound (A2) was reacted with ethyl acetoacetate in alcohol to yield corresponding pyrazole-6-methoxybenzothiazole (A4). Moreover, the compound (A2) was reacted with 4- substituted aromatic aldehydes in absolute ethanol to create Hydrazones (A5a-d). Synthesized compounds were investigated as anti-bacterial activity against five microorganisms:(Gram-positive: Bacillus subtilis & Staphylococcus aurea). (Gram-negative: Pseudomonas aeruginous Escherichia coli and Enterobacter)" @default.
- W3044821644 created "2020-07-29" @default.
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- W3044821644 date "2020-07-14" @default.
- W3044821644 modified "2023-09-27" @default.
- W3044821644 title "Design, Synthesis, Characterization and Biological Evaluation of 6-Methoxy-2-aminobenzothioate derivatives against certain bacterial strains." @default.
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- W3044821644 doi "https://doi.org/10.21608/ejchem.2020.24849.2474" @default.
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