FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044822053> ?p ?o ?g. }

• W3044822053 endingPage "112194" @default.
• W3044822053 startingPage "112194" @default.
• W3044822053 abstract "Inflammation plays a critical role in the development of atherosclerosis (AS), which has been identified as a major predisposing factor for stroke. Macrophages and VSMCs are associated with plaque formation and progression. Macrophages can dynamically change into two main functional phenotypes, namely M1 and M2, they can produce either pro-inflammatory or anti-inflammatory factors which may affect the outcome of inflammation. As a member of CTRPs family, CTRP9 has been reported play important protective roles in the cardiovascular system. However, whether CTRP9 can regulate macrophage activation status in inflammatory responses and have effect on VSMCs behaviors in co-culture system have not been fully investigated. In the present study, using peritoneal macrophages treated with CTRP9, we found that CTRP9 facilitated macrophages towards M1 phenotype, promoted TNF-α secretion and MMPs expression. CTRP9 showed synergistic effect with LPS in inducing M1 macrophages. In macrophages-VSMCs co-culture system, apoptosis and down-regulated proliferation of VSMCs were accelerated with CTRP9-treated macrophages. Then we attempted to explore the underlying molecular mechanisms of CTRP9 resulting in M1 activation. The c-Jun NH2-terminal kinases (JNK) are members of the mitogen activated protein kinases (MAPK) family, plays a central role in the cell stress response, with outcomes ranging from cell death to cell proliferation and survival. We found JNK expression was upregulated following CTRP9 stimulation, and inhibiting JNK phosphorylation level was associated with decreased expression of M1 markers and TNF-α concentration. Moreover, VSMCs apoptosis were ameliorated after inhibition of JNK. These results suggested that CTRP9 may promote macrophage towards M1 activation status through JNK signaling pathway activation." @default.
• W3044822053 created "2020-07-29" @default.
• W3044822053 creator A5000150649 @default.
• W3044822053 creator A5025185788 @default.
• W3044822053 creator A5027835055 @default.
• W3044822053 creator A5045361342 @default.
• W3044822053 creator A5046271092 @default.
• W3044822053 creator A5063965056 @default.
• W3044822053 creator A5071490870 @default.
• W3044822053 date "2020-10-01" @default.
• W3044822053 modified "2023-10-14" @default.
• W3044822053 title "CTRP9 induces macrophages polarization into M1 phenotype through activating JNK pathway and enhances VSMCs apoptosis in macrophages and VSMCs co-culture system" @default.
• W3044822053 cites W132967430 @default.
• W3044822053 cites W1573165312 @default.
• W3044822053 cites W1947083548 @default.
• W3044822053 cites W1972872816 @default.
• W3044822053 cites W1979956597 @default.
• W3044822053 cites W1990396303 @default.
• W3044822053 cites W2001209153 @default.
• W3044822053 cites W2006343812 @default.
• W3044822053 cites W2006498368 @default.
• W3044822053 cites W2018349757 @default.
• W3044822053 cites W2022922336 @default.
• W3044822053 cites W2042938039 @default.
• W3044822053 cites W2057835664 @default.
• W3044822053 cites W2076571657 @default.
• W3044822053 cites W2082416976 @default.
• W3044822053 cites W2088859232 @default.
• W3044822053 cites W2098443925 @default.
• W3044822053 cites W2128779572 @default.
• W3044822053 cites W2134408061 @default.
• W3044822053 cites W2145962927 @default.
• W3044822053 cites W2151941382 @default.
• W3044822053 cites W2155368792 @default.
• W3044822053 cites W2155737281 @default.
• W3044822053 cites W2161062626 @default.
• W3044822053 cites W2163436503 @default.
• W3044822053 cites W2165626477 @default.
• W3044822053 cites W2205830781 @default.
• W3044822053 cites W2317067038 @default.
• W3044822053 cites W2337898325 @default.
• W3044822053 cites W2338497789 @default.
• W3044822053 cites W2397457820 @default.
• W3044822053 cites W2465367340 @default.
• W3044822053 cites W2545733225 @default.
• W3044822053 cites W2556760519 @default.
• W3044822053 cites W2559767757 @default.
• W3044822053 cites W2587219230 @default.
• W3044822053 cites W2593609484 @default.
• W3044822053 cites W2609478948 @default.
• W3044822053 cites W2612072527 @default.
• W3044822053 cites W2620616004 @default.
• W3044822053 cites W2734176231 @default.
• W3044822053 cites W2768929128 @default.
• W3044822053 cites W2782685575 @default.
• W3044822053 cites W2790580076 @default.
• W3044822053 cites W2792785502 @default.
• W3044822053 cites W2804486220 @default.
• W3044822053 cites W2886824961 @default.
• W3044822053 cites W2896331764 @default.
• W3044822053 cites W2931022792 @default.
• W3044822053 cites W2944981629 @default.
• W3044822053 cites W2972423861 @default.
• W3044822053 cites W2996610629 @default.
• W3044822053 cites W4213245349 @default.
• W3044822053 cites W4256475235 @default.
• W3044822053 doi "https://doi.org/10.1016/j.yexcr.2020.112194" @default.
• W3044822053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32712018" @default.
• W3044822053 hasPublicationYear "2020" @default.
• W3044822053 type Work @default.
• W3044822053 sameAs 3044822053 @default.
• W3044822053 citedByCount "13" @default.
• W3044822053 countsByYear W30448220532021 @default.
• W3044822053 countsByYear W30448220532022 @default.
• W3044822053 countsByYear W30448220532023 @default.
• W3044822053 crossrefType "journal-article" @default.
• W3044822053 hasAuthorship W3044822053A5000150649 @default.
• W3044822053 hasAuthorship W3044822053A5025185788 @default.
• W3044822053 hasAuthorship W3044822053A5027835055 @default.
• W3044822053 hasAuthorship W3044822053A5045361342 @default.
• W3044822053 hasAuthorship W3044822053A5046271092 @default.
• W3044822053 hasAuthorship W3044822053A5063965056 @default.
• W3044822053 hasAuthorship W3044822053A5071490870 @default.
• W3044822053 hasConcept C104317684 @default.
• W3044822053 hasConcept C127561419 @default.
• W3044822053 hasConcept C17991360 @default.
• W3044822053 hasConcept C184235292 @default.
• W3044822053 hasConcept C190283241 @default.
• W3044822053 hasConcept C202751555 @default.
• W3044822053 hasConcept C203014093 @default.
• W3044822053 hasConcept C2776914184 @default.
• W3044822053 hasConcept C2779244956 @default.
• W3044822053 hasConcept C502942594 @default.
• W3044822053 hasConcept C55493867 @default.
• W3044822053 hasConcept C57074206 @default.
• W3044822053 hasConcept C62478195 @default.
• W3044822053 hasConcept C86803240 @default.
• W3044822053 hasConcept C95444343 @default.

• next