FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044843389> ?p ?o ?g. }

• W3044843389 endingPage "230" @default.
• W3044843389 startingPage "220" @default.
• W3044843389 abstract "Background Immune dysfunction is associated with posthemorrhagic shock mesenteric lymph (PHSML) return. To determine the proliferation and cytokine production capacity of CD4+ T lymphocytes, the effect of PHSML drainage on spleen CD4+ T lymphocytes in a mouse model of hemorrhagic shock was assessed. Methods The normal spleen CD4+ T lymphocytes were in vitro incubated with either drained normal mesenteric lymph (NML), PHSML during hypotension (PHSML-H), or PHSML from 0 h to 3 h after resuscitation (PHSML-R) to verify direct proliferation effects of PHSML. Results Hemorrhagic shock led to reduction of proliferation and mRNA expression of interleukin 2 (IL-2) and IL-2 receptor in CD4+ T lymphocytes and to decrease in IL-2 and interferon γ (IFN-γ) levels in supernatants. In contrast, the interleukin-4 levels were increased. These effects were reversed by PHSML drainage. Moreover, NML incubation promoted CD4+ T lymphocyte proliferation, whereas both PHSML-H and PHSML-R treatment had a biphasic effects on CD4+ T lymphocyte proliferation, exhibiting an enhanced effect at early stages and an inhibitory effect at later stages. Compared with NML, PHSML-H increased IL-2 expression at 12 h, but decreased expression of both IL-2 and IFN-γ at 24 h. By contrast, PHSML-R induced significant increases in IL-2 and IFN-γ levels at 24 h. Interleukin-4 expression in CD4+ T lymphocytes was reduced at 12 h, but augmented at 24 h after incubation with either PHSML-H or PHSML-R. Conclusions The results indicate that PHSML has a direct inhibitory effect on CD4+ T lymphocyte proliferation that induces an inflammatory response, which is associated with cellular immune dysfunction." @default.
• W3044843389 created "2020-07-29" @default.
• W3044843389 creator A5024544480 @default.
• W3044843389 creator A5046254187 @default.
• W3044843389 creator A5049396785 @default.
• W3044843389 creator A5051037307 @default.
• W3044843389 creator A5055736577 @default.
• W3044843389 creator A5056747247 @default.
• W3044843389 creator A5086465676 @default.
• W3044843389 date "2020-12-01" @default.
• W3044843389 modified "2023-09-25" @default.
• W3044843389 title "Engagement of Posthemorrhagic Shock Mesenteric Lymph on CD4+ T Lymphocytes In Vivo and In Vitro" @default.
• W3044843389 cites W1007701338 @default.
• W3044843389 cites W1636391291 @default.
• W3044843389 cites W190744314 @default.
• W3044843389 cites W1967222644 @default.
• W3044843389 cites W1968255783 @default.
• W3044843389 cites W1968717688 @default.
• W3044843389 cites W1979078052 @default.
• W3044843389 cites W1984518697 @default.
• W3044843389 cites W2002814423 @default.
• W3044843389 cites W2016005921 @default.
• W3044843389 cites W2019766373 @default.
• W3044843389 cites W2044675695 @default.
• W3044843389 cites W2052564398 @default.
• W3044843389 cites W2055862586 @default.
• W3044843389 cites W2063842938 @default.
• W3044843389 cites W2072860722 @default.
• W3044843389 cites W2075329867 @default.
• W3044843389 cites W2077342323 @default.
• W3044843389 cites W2080814925 @default.
• W3044843389 cites W2127857871 @default.
• W3044843389 cites W2136427421 @default.
• W3044843389 cites W2142912738 @default.
• W3044843389 cites W2151005625 @default.
• W3044843389 cites W2163143053 @default.
• W3044843389 cites W2313525907 @default.
• W3044843389 cites W2320114623 @default.
• W3044843389 cites W2323089882 @default.
• W3044843389 cites W2332838751 @default.
• W3044843389 cites W2333514747 @default.
• W3044843389 cites W2461258175 @default.
• W3044843389 cites W2540365220 @default.
• W3044843389 cites W2577207847 @default.
• W3044843389 cites W2579559250 @default.
• W3044843389 doi "https://doi.org/10.1016/j.jss.2020.06.044" @default.
• W3044843389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32711179" @default.
• W3044843389 hasPublicationYear "2020" @default.
• W3044843389 type Work @default.
• W3044843389 sameAs 3044843389 @default.
• W3044843389 citedByCount "6" @default.
• W3044843389 countsByYear W30448433892021 @default.
• W3044843389 countsByYear W30448433892022 @default.
• W3044843389 crossrefType "journal-article" @default.
• W3044843389 hasAuthorship W3044843389A5024544480 @default.
• W3044843389 hasAuthorship W3044843389A5046254187 @default.
• W3044843389 hasAuthorship W3044843389A5049396785 @default.
• W3044843389 hasAuthorship W3044843389A5051037307 @default.
• W3044843389 hasAuthorship W3044843389A5055736577 @default.
• W3044843389 hasAuthorship W3044843389A5056747247 @default.
• W3044843389 hasAuthorship W3044843389A5086465676 @default.
• W3044843389 hasConcept C126322002 @default.
• W3044843389 hasConcept C134018914 @default.
• W3044843389 hasConcept C142724271 @default.
• W3044843389 hasConcept C150903083 @default.
• W3044843389 hasConcept C185592680 @default.
• W3044843389 hasConcept C202751555 @default.
• W3044843389 hasConcept C203014093 @default.
• W3044843389 hasConcept C207001950 @default.
• W3044843389 hasConcept C25642318 @default.
• W3044843389 hasConcept C2777371288 @default.
• W3044843389 hasConcept C2777761686 @default.
• W3044843389 hasConcept C2778690821 @default.
• W3044843389 hasConcept C2779237934 @default.
• W3044843389 hasConcept C2779720271 @default.
• W3044843389 hasConcept C2780931953 @default.
• W3044843389 hasConcept C2992881475 @default.
• W3044843389 hasConcept C55493867 @default.
• W3044843389 hasConcept C71924100 @default.
• W3044843389 hasConcept C86803240 @default.
• W3044843389 hasConcept C8891405 @default.
• W3044843389 hasConceptScore W3044843389C126322002 @default.
• W3044843389 hasConceptScore W3044843389C134018914 @default.
• W3044843389 hasConceptScore W3044843389C142724271 @default.
• W3044843389 hasConceptScore W3044843389C150903083 @default.
• W3044843389 hasConceptScore W3044843389C185592680 @default.
• W3044843389 hasConceptScore W3044843389C202751555 @default.
• W3044843389 hasConceptScore W3044843389C203014093 @default.
• W3044843389 hasConceptScore W3044843389C207001950 @default.
• W3044843389 hasConceptScore W3044843389C25642318 @default.
• W3044843389 hasConceptScore W3044843389C2777371288 @default.
• W3044843389 hasConceptScore W3044843389C2777761686 @default.
• W3044843389 hasConceptScore W3044843389C2778690821 @default.
• W3044843389 hasConceptScore W3044843389C2779237934 @default.
• W3044843389 hasConceptScore W3044843389C2779720271 @default.
• W3044843389 hasConceptScore W3044843389C2780931953 @default.
• W3044843389 hasConceptScore W3044843389C2992881475 @default.
• W3044843389 hasConceptScore W3044843389C55493867 @default.

• next