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- W3044851812 abstract "Inspired by the chemistry and biology of isoflavones and pyrazolones, herein we report the first example of synthesis of 3-pyrazolyl isoflavones by two steps, starting from commercially available chromanones and pyrazolones. The [1,5]-proton transfer was used as a key strategy. All the 3-pyrazolyl isoflavones 3, which are hard to synthesize by traditional methods, are smoothly obtained in up to 86% total yield. Interestingly, the product forms a stable 7-membered ring through intramolecular hydrogen bond between carbonyl group on chromone core and hydroxyl group on pyrazolone core, preventing further ketone-enol tautomerization. In particular, the products are featured with an intriguing combination of two privileged motifs including isoflavone and pyrazolone substructures, which might be valuable in medicinal chemistry." @default.
- W3044851812 created "2020-07-29" @default.
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- W3044851812 date "2020-09-01" @default.
- W3044851812 modified "2023-09-23" @default.
- W3044851812 title "[1,5]-Proton transfer as a key strategy: Rapid access to natural product-inspired library of 3-pyrazolyl isoflavones" @default.
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- W3044851812 doi "https://doi.org/10.1016/j.tet.2020.131436" @default.
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