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- W3044879040 endingPage "488" @default.
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- W3044879040 abstract "Purpose of review Individuals with chronic kidney disease (CKD) are at increased risk of atherosclerotic cardiovascular disease (ASCVD) events. LDL cholesterol (LDL-C) is a key modifiable cause of ASCVD and lowering LDL-C with statins reduces the risk of ASCVD events in a wide range of populations, including those with CKD. This review considers the utility of recently developed nonstatin LDL-C-lowering therapies in CKD. Recent findings The cholesterol absorption inhibitor, ezetimibe, reduces LDL-C by 15–20% and is well tolerated in CKD. Monoclonal antibodies (mAbs) targeting proprotein convertase subtilisin kexin type 9 (PCSK9) reduce LDL-C by 50–60% and reduce the risk of ASCVD events. However, these agents require self-administration by subcutaneous injection every 2–4 weeks. The PCSK9 synthesis inhibitor, inclisiran, is administered approximately 6 monthly and may be more suitable for widespread use, although outcome trials are awaited. These PCSK9 targeting therapies require no dose adjustment in CKD and have no drug interactions. Summary Statins and ezetimibe are safe and reduce ASCVD risk in CKD populations. PCSK9 targeting agents may be useful in high-risk CKD patients, including those with prior ASCVD." @default.
- W3044879040 created "2020-07-29" @default.
- W3044879040 creator A5011517202 @default.
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- W3044879040 date "2020-07-21" @default.
- W3044879040 modified "2023-10-14" @default.
- W3044879040 title "LDL-cholesterol reduction in chronic kidney disease: options beyond statins" @default.
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- W3044879040 doi "https://doi.org/10.1097/mnh.0000000000000628" @default.
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