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• W3044896803 startingPage "80" @default.
• W3044896803 abstract "IP3 receptors (IP3Rs) are intracellular Ca2+ release channels gated by IP3 that are located in the endoplasmic reticulum (ER), including subregions that are in close contact with other organelles such as mitochondria. Recent studies have discovered unique properties of these channels in terms of the stoichiometric requirements for channel opening, their licensing to open in response to IP3 and their contribution to ER-mitochondrial contacts and Ca2+ transfers. In this mini-review, we provide a snapshot of the recent developments in our understanding of how IP3Rs impact and function at the ER-mitochondrial interface. We have focused this review on more recent discoveries that address questions such as: Which IP3R isoform is fueling Ca2+ to mitochondria? How are IP3Rs tethered to MAMs and how do IP3Rs contribute to MAM formation? And how are IP3Rs modulated at MAMs?" @default.
• W3044896803 created "2020-07-29" @default.
• W3044896803 creator A5019565239 @default.
• W3044896803 creator A5046708046 @default.
• W3044896803 creator A5049890385 @default.
• W3044896803 creator A5074668880 @default.
• W3044896803 creator A5084581276 @default.
• W3044896803 date "2020-10-01" @default.
• W3044896803 modified "2023-09-26" @default.
• W3044896803 title "Recent advances in understanding IP3R function with focus on ER-mitochondrial Ca2+ transfers" @default.
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