Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044897974> ?p ?o ?g. }
- W3044897974 endingPage "127429" @default.
- W3044897974 startingPage "127429" @default.
- W3044897974 abstract "Suppression of differentiation and/or function of osteoclasts is considered an effective therapeutic strategy for osteolytic bone diseases such as periodontitis and osteoporosis. Evidence regarding the health benefits of oolong tea consumption is accumulating, and tea polyphenols have various pharmacological properties such as anti-cancer and anti-diabetes effects. In this study, we investigated the effect of oolonghomobisflavan B (OFB), a polyphenolic compound in oolong tea, on osteoclast differentiation. OFB suppressed receptor activator of nuclear factor-κB (RANKL)-induced formation of tartate-resistant acid phosphatase-positive multinuclear cells without cytotoxicity. OFB also significantly attenuated p38 phosphorylation, which is essential for RANKL-induced osteoclastogenesis, and inhibited the expressions of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) and osteoclast-specific target genes, including dendritic cell-specific transmembrane protein and cathepsin K. Our findings suggest that OFB exhibits an anti-osteoclastogenic activity by inhibiting RANKL-mediated p38 activation, which is useful for the prevention and treatment of osteolytic bone diseases." @default.
- W3044897974 created "2020-07-29" @default.
- W3044897974 creator A5012145865 @default.
- W3044897974 creator A5022063457 @default.
- W3044897974 creator A5024321339 @default.
- W3044897974 creator A5024591702 @default.
- W3044897974 creator A5041455638 @default.
- W3044897974 creator A5049276892 @default.
- W3044897974 creator A5054602576 @default.
- W3044897974 creator A5067863151 @default.
- W3044897974 creator A5080001926 @default.
- W3044897974 creator A5085010633 @default.
- W3044897974 creator A5089329487 @default.
- W3044897974 date "2020-09-01" @default.
- W3044897974 modified "2023-09-27" @default.
- W3044897974 title "Inhibitory effect of oolonghomobisflavan B on osteoclastogenesis by suppressing p38 MAPK activation" @default.
- W3044897974 cites W1974554293 @default.
- W3044897974 cites W1995488553 @default.
- W3044897974 cites W1996058743 @default.
- W3044897974 cites W2000519650 @default.
- W3044897974 cites W2017372504 @default.
- W3044897974 cites W2018964274 @default.
- W3044897974 cites W2024053153 @default.
- W3044897974 cites W2024293017 @default.
- W3044897974 cites W2024455527 @default.
- W3044897974 cites W2072510816 @default.
- W3044897974 cites W2078066639 @default.
- W3044897974 cites W2078409020 @default.
- W3044897974 cites W2088172161 @default.
- W3044897974 cites W2093200966 @default.
- W3044897974 cites W2093252878 @default.
- W3044897974 cites W2094983273 @default.
- W3044897974 cites W2100359187 @default.
- W3044897974 cites W2112907122 @default.
- W3044897974 cites W2117420270 @default.
- W3044897974 cites W2130801611 @default.
- W3044897974 cites W2166266977 @default.
- W3044897974 cites W2184490864 @default.
- W3044897974 cites W2323800715 @default.
- W3044897974 cites W2329524020 @default.
- W3044897974 cites W2605260031 @default.
- W3044897974 cites W2611410760 @default.
- W3044897974 cites W2808736031 @default.
- W3044897974 cites W2905663314 @default.
- W3044897974 cites W2906362717 @default.
- W3044897974 cites W2928238096 @default.
- W3044897974 doi "https://doi.org/10.1016/j.bmcl.2020.127429" @default.
- W3044897974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32731089" @default.
- W3044897974 hasPublicationYear "2020" @default.
- W3044897974 type Work @default.
- W3044897974 sameAs 3044897974 @default.
- W3044897974 citedByCount "3" @default.
- W3044897974 countsByYear W30448979742021 @default.
- W3044897974 countsByYear W30448979742023 @default.
- W3044897974 crossrefType "journal-article" @default.
- W3044897974 hasAuthorship W3044897974A5012145865 @default.
- W3044897974 hasAuthorship W3044897974A5022063457 @default.
- W3044897974 hasAuthorship W3044897974A5024321339 @default.
- W3044897974 hasAuthorship W3044897974A5024591702 @default.
- W3044897974 hasAuthorship W3044897974A5041455638 @default.
- W3044897974 hasAuthorship W3044897974A5049276892 @default.
- W3044897974 hasAuthorship W3044897974A5054602576 @default.
- W3044897974 hasAuthorship W3044897974A5067863151 @default.
- W3044897974 hasAuthorship W3044897974A5080001926 @default.
- W3044897974 hasAuthorship W3044897974A5085010633 @default.
- W3044897974 hasAuthorship W3044897974A5089329487 @default.
- W3044897974 hasConcept C11960822 @default.
- W3044897974 hasConcept C126322002 @default.
- W3044897974 hasConcept C17077164 @default.
- W3044897974 hasConcept C185592680 @default.
- W3044897974 hasConcept C51551487 @default.
- W3044897974 hasConcept C55493867 @default.
- W3044897974 hasConcept C57074206 @default.
- W3044897974 hasConcept C71240020 @default.
- W3044897974 hasConcept C71924100 @default.
- W3044897974 hasConceptScore W3044897974C11960822 @default.
- W3044897974 hasConceptScore W3044897974C126322002 @default.
- W3044897974 hasConceptScore W3044897974C17077164 @default.
- W3044897974 hasConceptScore W3044897974C185592680 @default.
- W3044897974 hasConceptScore W3044897974C51551487 @default.
- W3044897974 hasConceptScore W3044897974C55493867 @default.
- W3044897974 hasConceptScore W3044897974C57074206 @default.
- W3044897974 hasConceptScore W3044897974C71240020 @default.
- W3044897974 hasConceptScore W3044897974C71924100 @default.
- W3044897974 hasIssue "18" @default.
- W3044897974 hasLocation W30448979741 @default.
- W3044897974 hasOpenAccess W3044897974 @default.
- W3044897974 hasPrimaryLocation W30448979741 @default.
- W3044897974 hasRelatedWork W1996140555 @default.
- W3044897974 hasRelatedWork W2006478883 @default.
- W3044897974 hasRelatedWork W2034225929 @default.
- W3044897974 hasRelatedWork W2049760197 @default.
- W3044897974 hasRelatedWork W2056415482 @default.
- W3044897974 hasRelatedWork W2056848217 @default.
- W3044897974 hasRelatedWork W2376631516 @default.
- W3044897974 hasRelatedWork W2388924678 @default.
- W3044897974 hasRelatedWork W2951073070 @default.
- W3044897974 hasRelatedWork W2951316352 @default.