Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044929217> ?p ?o ?g. }
- W3044929217 endingPage "5279" @default.
- W3044929217 startingPage "5279" @default.
- W3044929217 abstract "Venous thromboembolism (VTE) is an important cause of vascular morbidity and mortality. Many risk factors have been identified for venous thrombosis that lead to alterations in blood flow, activate the vascular endothelium, and increase the propensity for blood coagulation. However, the precise molecular and cellular mechanisms that cause blood clots in the venous vasculature have not been fully elucidated. Patients with sickle cell disease (SCD) demonstrate all the risk factors for venous stasis, activated endothelium, and blood hypercoagulability, making them particularly vulnerable to VTE. In this review, we will discuss how mouse models have elucidated the complex vascular pathobiology of SCD. We review the dysregulated pathways of inflammation and coagulation in SCD and how the resultant hypercoagulable state can potentiate thrombosis through down-regulation of vascular anticoagulants. Studies of VTE pathogenesis using SCD mouse models may provide insight into the intersection between the cellular and molecular processes involving inflammation and coagulation and help to identify novel mechanistic pathways." @default.
- W3044929217 created "2020-07-29" @default.
- W3044929217 creator A5049700042 @default.
- W3044929217 creator A5058977028 @default.
- W3044929217 date "2020-07-25" @default.
- W3044929217 modified "2023-10-01" @default.
- W3044929217 title "Sickle Cell Disease: A Paradigm for Venous Thrombosis Pathophysiology" @default.
- W3044929217 cites W1505276695 @default.
- W3044929217 cites W1528211603 @default.
- W3044929217 cites W1555465190 @default.
- W3044929217 cites W1578844443 @default.
- W3044929217 cites W1584253018 @default.
- W3044929217 cites W1663316730 @default.
- W3044929217 cites W173963036 @default.
- W3044929217 cites W1773306847 @default.
- W3044929217 cites W1891626881 @default.
- W3044929217 cites W1935876833 @default.
- W3044929217 cites W1956481325 @default.
- W3044929217 cites W1956547191 @default.
- W3044929217 cites W1968642156 @default.
- W3044929217 cites W1972406498 @default.
- W3044929217 cites W1977708103 @default.
- W3044929217 cites W1977902516 @default.
- W3044929217 cites W1978407650 @default.
- W3044929217 cites W1981361161 @default.
- W3044929217 cites W1982958883 @default.
- W3044929217 cites W1983417355 @default.
- W3044929217 cites W1983760732 @default.
- W3044929217 cites W1984887661 @default.
- W3044929217 cites W1986747192 @default.
- W3044929217 cites W1990033742 @default.
- W3044929217 cites W1991664249 @default.
- W3044929217 cites W1992431516 @default.
- W3044929217 cites W1992525172 @default.
- W3044929217 cites W1992577724 @default.
- W3044929217 cites W1993539946 @default.
- W3044929217 cites W1995931298 @default.
- W3044929217 cites W2001376188 @default.
- W3044929217 cites W2006679777 @default.
- W3044929217 cites W2010836598 @default.
- W3044929217 cites W2014454039 @default.
- W3044929217 cites W2016226738 @default.
- W3044929217 cites W2016928370 @default.
- W3044929217 cites W2022749031 @default.
- W3044929217 cites W2023292153 @default.
- W3044929217 cites W2028718935 @default.
- W3044929217 cites W2030455963 @default.
- W3044929217 cites W2033104621 @default.
- W3044929217 cites W2039453307 @default.
- W3044929217 cites W2042433863 @default.
- W3044929217 cites W2045819100 @default.
- W3044929217 cites W2049292864 @default.
- W3044929217 cites W2050147761 @default.
- W3044929217 cites W2050985847 @default.
- W3044929217 cites W2058188211 @default.
- W3044929217 cites W2059495092 @default.
- W3044929217 cites W2064973550 @default.
- W3044929217 cites W2066856450 @default.
- W3044929217 cites W2067738744 @default.
- W3044929217 cites W2075895818 @default.
- W3044929217 cites W2081139146 @default.
- W3044929217 cites W2083884362 @default.
- W3044929217 cites W2089632198 @default.
- W3044929217 cites W2089819802 @default.
- W3044929217 cites W2092330685 @default.
- W3044929217 cites W2093499369 @default.
- W3044929217 cites W2095601555 @default.
- W3044929217 cites W2098847286 @default.
- W3044929217 cites W2110418017 @default.
- W3044929217 cites W2114965110 @default.
- W3044929217 cites W2117563227 @default.
- W3044929217 cites W2119580559 @default.
- W3044929217 cites W2123458472 @default.
- W3044929217 cites W2134053129 @default.
- W3044929217 cites W2137744809 @default.
- W3044929217 cites W2142385132 @default.
- W3044929217 cites W2142649232 @default.
- W3044929217 cites W2149786825 @default.
- W3044929217 cites W2158519357 @default.
- W3044929217 cites W2161859232 @default.
- W3044929217 cites W2172191543 @default.
- W3044929217 cites W2215583678 @default.
- W3044929217 cites W2258503797 @default.
- W3044929217 cites W2267226449 @default.
- W3044929217 cites W2289141679 @default.
- W3044929217 cites W2294236942 @default.
- W3044929217 cites W2410713688 @default.
- W3044929217 cites W2412746466 @default.
- W3044929217 cites W2508261355 @default.
- W3044929217 cites W2523917817 @default.
- W3044929217 cites W2550286404 @default.
- W3044929217 cites W2557300344 @default.
- W3044929217 cites W2559643145 @default.
- W3044929217 cites W2559847201 @default.
- W3044929217 cites W2559885961 @default.
- W3044929217 cites W2560437439 @default.
- W3044929217 cites W2578853149 @default.
- W3044929217 cites W2588943086 @default.