FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044938093> ?p ?o ?g. }

• W3044938093 abstract "Abstract Background We previously showed that BRCA-like profiles can be used to preselect individuals with the highest risk of carrying BRCA mutations but could also indicate which patients would benefit from double-strand break inducing chemotherapy. A simple, robust, and reliable assay for clinical use that utilizes limited amounts of formalin-fixed, paraffin-embedded tumor tissue to assess BRCAness status in both ER-positive and ER-negative breast cancer (BC) is currently lacking. Methods A digital multiplex ligation-dependent probe amplification (digitalMLPA) assay was designed to detect copy number alterations required for the classification of BRCA1-like and BRCA2-like BC. The BRCA1-like classifier was trained on 71 tumors, enriched for triple-negative BC; the BRCA2-like classifier was trained on 55 tumors, enriched for luminal-type BC. A shrunken centroid-based classifier was developed and applied on an independent validation cohort. A total of 114 cases of a randomized controlled trial were analyzed, and the association of the classifier result with intensified platinum-based chemotherapy response was assessed. Results The digitalMLPA BRCA1-like classifier correctly classified 91% of the BRCA1-like samples and 82% of the BRCA2-like samples. Patients with a BRCA-like tumor derived significant benefit of high-dose chemotherapy (adjusted hazard ratio (HR) 0.12, 95% CI 0.04–0.44) which was not observed in non-BRCA-like patients (HR 0.9, 95% CI 0.37–2.18) ( p = 0.01). Analysis stratified for ER status showed borderline significance. Conclusions The digitalMLPA is a reliable method to detect a BRCA1- and BRCA2-like pattern on clinical samples and predicts platinum-based chemotherapy benefit in both triple-negative and luminal-type BC." @default.
• W3044938093 created "2020-07-29" @default.
• W3044938093 creator A5009334933 @default.
• W3044938093 creator A5020517461 @default.
• W3044938093 creator A5029689310 @default.
• W3044938093 creator A5048962936 @default.
• W3044938093 creator A5052915247 @default.
• W3044938093 creator A5063917865 @default.
• W3044938093 creator A5076006564 @default.
• W3044938093 creator A5079501701 @default.
• W3044938093 creator A5082790595 @default.
• W3044938093 date "2020-07-25" @default.
• W3044938093 modified "2023-10-08" @default.
• W3044938093 title "BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer" @default.
• W3044938093 cites W1964744298 @default.
• W3044938093 cites W1964932691 @default.
• W3044938093 cites W1973560717 @default.
• W3044938093 cites W1990013137 @default.
• W3044938093 cites W2073618702 @default.
• W3044938093 cites W2083508318 @default.
• W3044938093 cites W2098652713 @default.
• W3044938093 cites W2109772731 @default.
• W3044938093 cites W2113734556 @default.
• W3044938093 cites W2113926943 @default.
• W3044938093 cites W2125062016 @default.
• W3044938093 cites W2133258471 @default.
• W3044938093 cites W2135724221 @default.
• W3044938093 cites W2138550913 @default.
• W3044938093 cites W2149207987 @default.
• W3044938093 cites W2149332737 @default.
• W3044938093 cites W2150133682 @default.
• W3044938093 cites W2155574915 @default.
• W3044938093 cites W2157693315 @default.
• W3044938093 cites W2169790254 @default.
• W3044938093 cites W2170719826 @default.
• W3044938093 cites W2288454796 @default.
• W3044938093 cites W2313938789 @default.
• W3044938093 cites W2528228811 @default.
• W3044938093 cites W2557666746 @default.
• W3044938093 cites W2559346232 @default.
• W3044938093 cites W2596164112 @default.
• W3044938093 cites W2737720491 @default.
• W3044938093 cites W2749898086 @default.
• W3044938093 cites W2751474182 @default.
• W3044938093 cites W2779333875 @default.
• W3044938093 cites W2779944044 @default.
• W3044938093 cites W2801956643 @default.
• W3044938093 cites W2896626889 @default.
• W3044938093 cites W2944623054 @default.
• W3044938093 cites W2947560052 @default.
• W3044938093 cites W3004709074 @default.
• W3044938093 doi "https://doi.org/10.1186/s13058-020-01313-7" @default.
• W3044938093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7382055" @default.
• W3044938093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32711554" @default.
• W3044938093 hasPublicationYear "2020" @default.
• W3044938093 type Work @default.
• W3044938093 sameAs 3044938093 @default.
• W3044938093 citedByCount "5" @default.
• W3044938093 countsByYear W30449380932020 @default.
• W3044938093 countsByYear W30449380932022 @default.
• W3044938093 crossrefType "journal-article" @default.
• W3044938093 hasAuthorship W3044938093A5009334933 @default.
• W3044938093 hasAuthorship W3044938093A5020517461 @default.
• W3044938093 hasAuthorship W3044938093A5029689310 @default.
• W3044938093 hasAuthorship W3044938093A5048962936 @default.
• W3044938093 hasAuthorship W3044938093A5052915247 @default.
• W3044938093 hasAuthorship W3044938093A5063917865 @default.
• W3044938093 hasAuthorship W3044938093A5076006564 @default.
• W3044938093 hasAuthorship W3044938093A5079501701 @default.
• W3044938093 hasAuthorship W3044938093A5082790595 @default.
• W3044938093 hasBestOaLocation W30449380931 @default.
• W3044938093 hasConcept C121608353 @default.
• W3044938093 hasConcept C126322002 @default.
• W3044938093 hasConcept C142724271 @default.
• W3044938093 hasConcept C143998085 @default.
• W3044938093 hasConcept C207103383 @default.
• W3044938093 hasConcept C2776694085 @default.
• W3044938093 hasConcept C2780110267 @default.
• W3044938093 hasConcept C2780140570 @default.
• W3044938093 hasConcept C44249647 @default.
• W3044938093 hasConcept C530470458 @default.
• W3044938093 hasConcept C71924100 @default.
• W3044938093 hasConceptScore W3044938093C121608353 @default.
• W3044938093 hasConceptScore W3044938093C126322002 @default.
• W3044938093 hasConceptScore W3044938093C142724271 @default.
• W3044938093 hasConceptScore W3044938093C143998085 @default.
• W3044938093 hasConceptScore W3044938093C207103383 @default.
• W3044938093 hasConceptScore W3044938093C2776694085 @default.
• W3044938093 hasConceptScore W3044938093C2780110267 @default.
• W3044938093 hasConceptScore W3044938093C2780140570 @default.
• W3044938093 hasConceptScore W3044938093C44249647 @default.
• W3044938093 hasConceptScore W3044938093C530470458 @default.
• W3044938093 hasConceptScore W3044938093C71924100 @default.
• W3044938093 hasFunder F4320319985 @default.
• W3044938093 hasFunder F4320323596 @default.
• W3044938093 hasLocation W30449380931 @default.
• W3044938093 hasLocation W30449380932 @default.
• W3044938093 hasLocation W30449380933 @default.
• W3044938093 hasLocation W30449380934 @default.
• W3044938093 hasOpenAccess W3044938093 @default.

• next