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• W3044943998 endingPage "139" @default.
• W3044943998 startingPage "117" @default.
• W3044943998 abstract "Introduction Worldwide, gastric cancer (GC) is one of the most deadly carcinomas ranking fifth in the order of occurrence and third in mortality. The effective management of GC patients remains poor even with the noticeable advancements in surgical, radio- and chemo-therapeutic approaches. One of the major problems is the failure in early diagnosis of the disease and non-availability of efficient prognostic biomarkers. Identification of key players contributing towards initiation and progression of the disease helps in formulating strategies for the effective treatment of gastric cancer. Recent studies have implicated the dysregulation of heat shock proteins (Hsp) in the occurrence of human malignant tumors, suggesting their potential to be explored as biomarkers in the diagnosis and prognosis of gastric cancer. In here, we aim to summarize information available on implication of dysregulation of Hsp in gastric tumorigenesis and current Hsp based approaches being exploited for the treatment of gastric cancer. Methods Authors reviewed the findings of all relevant reports available showing association of Hsp in the initiation, progression, metastasis, and treatment of gastric cancer. Results Review of dysregulation of major Hsp including HSP27, HSP40, HSP60, HSP70, and HSP90 and role of heat shock factors (HSFs) in gastric tumorigenesis suggests their importance in the molecular pathogenesis of gastric cancer. Hsp based biomarkers are being explored for their diagnostic and prognostic value. The Hsp based approaches including the use of Hsp inhibitors and Hsp based vaccines provide new directions to GC treatment. The information on HSp70 polymorphism and its association with H. pylori and EBV positive gastric cancer is also being presented. Conclusions The differential expression of various Hsp has been implicated as a key event in the initiation and progression of tumor growth and metastasis. Therefore, Hsp based approaches are being explored for diagnosis, prognosis and treatment of cancer. Although Hsp inhibitors and vaccines are finding their application in cancer management, still substantial focussed efforts are required to develop a widely accepted treatment regime involving Hsp. Nevertheless, a few of these Hsp inhibitors have been promoted to the next clinical phases with encouraging outcomes. Increased efficiency has been accomplished in the combined therapy as compared to the independent monotherapy since inhibitors in combination overcome the resistance resulting from the single inhibitor approach." @default.
• W3044943998 created "2020-07-29" @default.
• W3044943998 creator A5034046625 @default.
• W3044943998 creator A5069929548 @default.
• W3044943998 date "2020-01-01" @default.
• W3044943998 modified "2023-10-05" @default.
• W3044943998 title "Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer" @default.
• W3044943998 cites W1500803775 @default.
• W3044943998 cites W1515506492 @default.
• W3044943998 cites W1588132881 @default.
• W3044943998 cites W1965990265 @default.
• W3044943998 cites W1971190195 @default.
• W3044943998 cites W1979632314 @default.
• W3044943998 cites W1981765038 @default.
• W3044943998 cites W1982494194 @default.
• W3044943998 cites W1982690259 @default.
• W3044943998 cites W1988533633 @default.
• W3044943998 cites W1988675578 @default.
• W3044943998 cites W1990103226 @default.
• W3044943998 cites W1990772742 @default.
• W3044943998 cites W1993676104 @default.
• W3044943998 cites W1997041432 @default.
• W3044943998 cites W1997390346 @default.
• W3044943998 cites W1997673315 @default.
• W3044943998 cites W1999752916 @default.
• W3044943998 cites W2002851265 @default.
• W3044943998 cites W2007501972 @default.
• W3044943998 cites W2012731165 @default.
• W3044943998 cites W2016224818 @default.
• W3044943998 cites W2017258410 @default.
• W3044943998 cites W2017516497 @default.
• W3044943998 cites W2025281252 @default.
• W3044943998 cites W2026119643 @default.
• W3044943998 cites W2026564047 @default.
• W3044943998 cites W2031540128 @default.
• W3044943998 cites W2033106731 @default.
• W3044943998 cites W2040359453 @default.
• W3044943998 cites W2040643325 @default.
• W3044943998 cites W2040688801 @default.
• W3044943998 cites W2041660879 @default.
• W3044943998 cites W2042124205 @default.
• W3044943998 cites W2042985720 @default.
• W3044943998 cites W2043709310 @default.
• W3044943998 cites W2048243197 @default.
• W3044943998 cites W2050430721 @default.
• W3044943998 cites W2051051883 @default.
• W3044943998 cites W2055996962 @default.
• W3044943998 cites W2056007562 @default.
• W3044943998 cites W2057620884 @default.
• W3044943998 cites W2063396898 @default.
• W3044943998 cites W2065601529 @default.
• W3044943998 cites W2065829421 @default.
• W3044943998 cites W2069216709 @default.
• W3044943998 cites W2071274102 @default.
• W3044943998 cites W2079228714 @default.
• W3044943998 cites W2085296828 @default.
• W3044943998 cites W2086185470 @default.
• W3044943998 cites W2088225005 @default.
• W3044943998 cites W2089375954 @default.
• W3044943998 cites W2089400513 @default.
• W3044943998 cites W2090316478 @default.
• W3044943998 cites W2092923173 @default.
• W3044943998 cites W2094605832 @default.
• W3044943998 cites W2097506306 @default.
• W3044943998 cites W2103327164 @default.
• W3044943998 cites W2103872250 @default.
• W3044943998 cites W2104935252 @default.
• W3044943998 cites W2106152750 @default.
• W3044943998 cites W2107038109 @default.
• W3044943998 cites W2108205327 @default.
• W3044943998 cites W2108502796 @default.
• W3044943998 cites W2113184090 @default.
• W3044943998 cites W2113960129 @default.
• W3044943998 cites W2116643833 @default.
• W3044943998 cites W2117692326 @default.
• W3044943998 cites W2119528020 @default.
• W3044943998 cites W2120719343 @default.
• W3044943998 cites W2122578071 @default.
• W3044943998 cites W2125007784 @default.
• W3044943998 cites W2130380927 @default.
• W3044943998 cites W2131749219 @default.
• W3044943998 cites W2131805766 @default.
• W3044943998 cites W2132221537 @default.
• W3044943998 cites W2133678710 @default.
• W3044943998 cites W2133997186 @default.
• W3044943998 cites W2136862034 @default.
• W3044943998 cites W2141346487 @default.
• W3044943998 cites W2142618672 @default.
• W3044943998 cites W2144326073 @default.
• W3044943998 cites W2147281621 @default.
• W3044943998 cites W2150378018 @default.
• W3044943998 cites W2152001500 @default.
• W3044943998 cites W2152537736 @default.
• W3044943998 cites W2154904733 @default.
• W3044943998 cites W2159087536 @default.
• W3044943998 cites W2159302760 @default.
• W3044943998 cites W2160145097 @default.
• W3044943998 cites W2160269498 @default.

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