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- W3044961827 abstract "BACKGROUND:Hyperlipidemia is the most common modifiable risk factor for atherosclerosis which causes increased morbidity and mortality in middle aged and elderly people worldwide.Statins are the first line drugs for hyperlipidemia. Policosanol, a mixture of natural aliphatic alcohols could decrease the LDL-C and Total Cholesterol and could increaseHDL-C without much side effects. No Indian studies are available for this hypolipidemic action of policosanol in Indian population. So this study is carried out to study the efficacy and tolerability of policosanol in addition to atorvastatin in patients with hyperlipidemia.OBJECTIVES:To assess the reduction in LDL-C, Total Cholesterol and the increase in HDL-C.METHODS:Hyperlipidemic patients attending the OPD of Rajiv Gandhi Government General Hospital are randomized into two groups (n=50 each). Control Group received 10 mg of T.Atorvastatin and Test Group received 10 mg of T.Atorvastatin and 10 mg of C.Policosanol for 8 weeks and followed-up after 4 weeks.RESULTS:The Total cholesterol and LDL-C decreased by 20.8% and 31% in test group and 12.12% and 16.5% in control group respectively (P<0.001). HDL-C increased by 11.2% in test group and 5.2% in control group (P<0.001). No significant reduction in triglyceride was noted. No serious adverse effects occurred.CONCLUSION:We conclude that policosanol with atorvastatin is effective in reducing lipid levels without a need for dose escalation of atorvastatin and is well tolerated." @default.
- W3044961827 created "2020-07-29" @default.
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- W3044961827 date "2017-04-01" @default.
- W3044961827 modified "2023-09-26" @default.
- W3044961827 title "A Prospective, Randomized, Open Label, Comparative Study of Policosanol as an Add on Therapy to Atorvastatin in patients with Hyperlipidaemia" @default.
- W3044961827 hasPublicationYear "2017" @default.
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