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• W3044962314 abstract "Abstract Given the importance of DNA methylation in protection of the genome against transposable elements and transcriptional regulation in other taxonomic groups, the diversity in both levels and patterns of DNA methylation in the insects raises questions about its function and evolution. We show that the maintenance DNA methyltransferase, DNMT1, affects meiosis and is essential to fertility in milkweed bugs, Oncopeltus fasciatus , while DNA methylation is not required in somatic cells. Our results support the hypothesis that Dnmt1 is required for the transition of germ cells to gametes in O. fasciatus and that this function is conserved in male and female gametogenesis. They further suggest that DNMT1 has a function independent of DNA methylation in germ cells. Our results raise the question of how a gene so critical in fitness across multiple insect species can have diverged widely across the insect tree of life." @default.
• W3044962314 created "2020-07-29" @default.
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• W3044962314 date "2020-07-24" @default.
• W3044962314 modified "2023-10-18" @default.
• W3044962314 title "The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus" @default.
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• W3044962314 doi "https://doi.org/10.1101/2020.07.23.218180" @default.
• W3044962314 hasPublicationYear "2020" @default.
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