FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044970663> ?p ?o ?g. }

• W3044970663 endingPage "153303382094231" @default.
• W3044970663 startingPage "153303382094231" @default.
• W3044970663 abstract "Objectives: This study was to explore the effect of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D knockdown on proliferation and apoptosis as well as p38 MAPK/p53 signaling pathway in acute myeloid leukemia. Methods: The expression of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D was detected in acute myeloid leukemia cell lines including SKM-1, KG-1, AML-193, and THP-1 cells, and normal bone marrow mononuclear cells isolated from healthy donors. The knockdown of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D was conducted by transfecting small interfering RNA into AML-193 cells and KG-1 cells. Results: The relative messenger RNA/protein expressions of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D were higher in SKM-1, KG-1, AML-193, and THP-1 cells compared with control cells (normal bone marrow mononuclear cells). After transfecting protein phosphatase, Mg 2+ /Mn 2+ dependent 1D small interfering RNA into AML-193 cells and KG-1 cells, both messenger RNA and protein expressions of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D were significantly reduced, indicating the successful transfection. Most importantly, knockdown of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D suppressed cell proliferation and promoted cell apoptosis in AML-193 cells and KG-1 cells. In addition, knockdown of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D enhanced the expressions of p-p38 and p53 in AML-193 cells and KG-1 cells. The above observation suggested that protein phosphatase, Mg 2+ /Mn 2+ dependent 1D knockdown suppressed cell proliferation, promoted cell apoptosis, and activated p38 MAPK/p53 signaling pathway in acute myeloid leukemia cells. Conclusion: Protein phosphatase, Mg 2+ /Mn 2+ dependent 1D is implicated in acute myeloid leukemia carcinogenesis, which illuminates its potential role as a treatment target for acute myeloid leukemia." @default.
• W3044970663 created "2020-07-29" @default.
• W3044970663 creator A5036546912 @default.
• W3044970663 creator A5038326454 @default.
• W3044970663 creator A5040085560 @default.
• W3044970663 creator A5048485669 @default.
• W3044970663 creator A5050470383 @default.
• W3044970663 creator A5061819699 @default.
• W3044970663 creator A5074702615 @default.
• W3044970663 date "2020-01-01" @default.
• W3044970663 modified "2023-09-29" @default.
• W3044970663 title "PPM1D Knockdown Suppresses Cell Proliferation, Promotes Cell Apoptosis, and Activates p38 MAPK/p53 Signaling Pathway in Acute Myeloid Leukemia" @default.
• W3044970663 cites W2025998282 @default.
• W3044970663 cites W2040169548 @default.
• W3044970663 cites W2069175122 @default.
• W3044970663 cites W2074364031 @default.
• W3044970663 cites W2074524882 @default.
• W3044970663 cites W2103314538 @default.
• W3044970663 cites W2105135849 @default.
• W3044970663 cites W2149848093 @default.
• W3044970663 cites W2169024565 @default.
• W3044970663 cites W2209081561 @default.
• W3044970663 cites W2419140434 @default.
• W3044970663 cites W2461928138 @default.
• W3044970663 cites W2899547828 @default.
• W3044970663 cites W2900205062 @default.
• W3044970663 cites W2905642920 @default.
• W3044970663 cites W2921337426 @default.
• W3044970663 cites W2958488683 @default.
• W3044970663 cites W2970333258 @default.
• W3044970663 cites W4231346141 @default.
• W3044970663 doi "https://doi.org/10.1177/1533033820942312" @default.
• W3044970663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7375723" @default.
• W3044970663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32691668" @default.
• W3044970663 hasPublicationYear "2020" @default.
• W3044970663 type Work @default.
• W3044970663 sameAs 3044970663 @default.
• W3044970663 citedByCount "5" @default.
• W3044970663 countsByYear W30449706632021 @default.
• W3044970663 countsByYear W30449706632022 @default.
• W3044970663 countsByYear W30449706632023 @default.
• W3044970663 crossrefType "journal-article" @default.
• W3044970663 hasAuthorship W3044970663A5036546912 @default.
• W3044970663 hasAuthorship W3044970663A5038326454 @default.
• W3044970663 hasAuthorship W3044970663A5040085560 @default.
• W3044970663 hasAuthorship W3044970663A5048485669 @default.
• W3044970663 hasAuthorship W3044970663A5050470383 @default.
• W3044970663 hasAuthorship W3044970663A5061819699 @default.
• W3044970663 hasAuthorship W3044970663A5074702615 @default.
• W3044970663 hasBestOaLocation W30449706631 @default.
• W3044970663 hasConcept C11960822 @default.
• W3044970663 hasConcept C153911025 @default.
• W3044970663 hasConcept C173396325 @default.
• W3044970663 hasConcept C178666793 @default.
• W3044970663 hasConcept C185592680 @default.
• W3044970663 hasConcept C190283241 @default.
• W3044970663 hasConcept C22615655 @default.
• W3044970663 hasConcept C2778729363 @default.
• W3044970663 hasConcept C2779408958 @default.
• W3044970663 hasConcept C502942594 @default.
• W3044970663 hasConcept C51551487 @default.
• W3044970663 hasConcept C54009773 @default.
• W3044970663 hasConcept C54355233 @default.
• W3044970663 hasConcept C55493867 @default.
• W3044970663 hasConcept C57074206 @default.
• W3044970663 hasConcept C62112901 @default.
• W3044970663 hasConcept C62478195 @default.
• W3044970663 hasConcept C81885089 @default.
• W3044970663 hasConcept C86803240 @default.
• W3044970663 hasConcept C95444343 @default.
• W3044970663 hasConceptScore W3044970663C11960822 @default.
• W3044970663 hasConceptScore W3044970663C153911025 @default.
• W3044970663 hasConceptScore W3044970663C173396325 @default.
• W3044970663 hasConceptScore W3044970663C178666793 @default.
• W3044970663 hasConceptScore W3044970663C185592680 @default.
• W3044970663 hasConceptScore W3044970663C190283241 @default.
• W3044970663 hasConceptScore W3044970663C22615655 @default.
• W3044970663 hasConceptScore W3044970663C2778729363 @default.
• W3044970663 hasConceptScore W3044970663C2779408958 @default.
• W3044970663 hasConceptScore W3044970663C502942594 @default.
• W3044970663 hasConceptScore W3044970663C51551487 @default.
• W3044970663 hasConceptScore W3044970663C54009773 @default.
• W3044970663 hasConceptScore W3044970663C54355233 @default.
• W3044970663 hasConceptScore W3044970663C55493867 @default.
• W3044970663 hasConceptScore W3044970663C57074206 @default.
• W3044970663 hasConceptScore W3044970663C62112901 @default.
• W3044970663 hasConceptScore W3044970663C62478195 @default.
• W3044970663 hasConceptScore W3044970663C81885089 @default.
• W3044970663 hasConceptScore W3044970663C86803240 @default.
• W3044970663 hasConceptScore W3044970663C95444343 @default.
• W3044970663 hasLocation W30449706631 @default.
• W3044970663 hasLocation W30449706632 @default.
• W3044970663 hasLocation W30449706633 @default.
• W3044970663 hasOpenAccess W3044970663 @default.
• W3044970663 hasPrimaryLocation W30449706631 @default.
• W3044970663 hasRelatedWork W2004726042 @default.
• W3044970663 hasRelatedWork W2144611693 @default.
• W3044970663 hasRelatedWork W2372390227 @default.

• next