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• W3044985268 abstract "Objectives: To assess the response to initial oxygenation strategy according to clinical variables available at admission. Design: Multicenter cohort study. Setting: Thirty French and Belgium medical ICU. Subjects: Immunocompromised patients with hypoxemic acute respiratory failure. Interventions: None. Measurements and Main Results: Data were extracted from the Groupe de Recherche en Reanimation Respiratoire du patient d'Onco-Hématologie database. Need for invasive mechanical ventilation was the primary endpoint. Secondary endpoint was day-28 mortality. Six-hundred forty-nine patients were included. First oxygenation strategies included standard oxygen ( n = 245, 38%), noninvasive ventilation ( n = 285; 44%), high-flow nasal cannula oxygen ( n = 55; 8%), and noninvasive ventilation + high-flow nasal cannula oxygen ( n = 64; 10%). Bilateral alveolar pattern (odds ratio = 1.67 [1.03–2.69]; p = 0.04), bacterial (odds ratio = 1.98 [1.07–3.65]; p = 0.03) or opportunistic infection (odds ratio = 4.75 [2.23–10.1]; p < 0.001), noninvasive ventilation use (odds ratio = 2.85 [1.73–4.70]; p < 0.001), Sequential Organ Failure Assessment score (odds ratio = 1.19 [1.10–1.28]; p < 0.001), and ratio of Pa o 2 and F io 2 less than 100 at ICU admission (odds ratio = 1.96 [1.27–3.02]; p = 0.0002) were independently associated with intubation rate. Day-28 mortality was independently associated with bacterial (odds ratio = 2.34 [1.10–4.97]; p = 0.03) or opportunistic infection (odds ratio = 4.96 [2.11–11.6]; p < 0.001), noninvasive ventilation use (odds ratio = 2.35 [1.35–4.09]; p = 0.003), Sequential Organ Failure Assessment score (odds ratio = 1.19 [1.10–1.28]; p < 0.001), and ratio of Pa o 2 and F io 2 less than 100 at ICU admission (odds ratio = 1.97 [1.26–3.09]; p = 0.003). High-flow nasal cannula oxygen use was neither associated with intubation nor mortality rates. Conclusions: Some clinical characteristics at ICU admission including etiology and severity of acute respiratory failure enable to identify patients at high risk for intubation." @default.
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• W3044985268 date "2020-07-20" @default.
• W3044985268 modified "2023-10-15" @default.
• W3044985268 title "Oxygenation Strategy During Acute Respiratory Failure in Critically-Ill Immunocompromised Patients" @default.
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• W3044985268 doi "https://doi.org/10.1097/ccm.0000000000004456" @default.
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