FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044994201> ?p ?o ?g. }

• W3044994201 endingPage "742" @default.
• W3044994201 startingPage "737" @default.
• W3044994201 abstract "To investigate the relationship between 1-hour lactate (1 h Lac) and 30-day mortality in critical care patients in intensive care unit (ICU).A retrospective, observational cohort study was performed with adult critical patients (age ≥ 16 years old) having lactate records within 1 hour after ICU admission from Medical Information Mart for Intensive Care-III database (MIMIC-III). According to the 1 h Lac level, the patients were divided into three groups: < 2 mmol/L, 2-4 mmol/L, and > 4 mmol/L groups. The baseline characteristics were analyzed. Multivariable Logistic regression analysis was performed to assess the association between 1 h Lac and 30-day mortality. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of 1 h Lac for 30-day mortality, and Kaplan-Meier survival curve was performed according to the best cut-off value. In addition, sensitivity analysis was carried out for each classification variable.A total of 3 969 ICU patients were included, with 673 died in 30 days, and the total mortality was 16.95%. There were 1 664, 1 588, 717 patients in Lac < 2 mmol/L, 2-4 mmol/L and > 4 mmol/L group, respectively. There were significant differences in age, ICU duration, ICU type, heart rate, leukocyte count, hemoglobin, creatinine, sequential organ failure score (SOFA), ventilator application, vasoactive drug use and main diagnosis among the three groups. Multivariable Logistic regression analysis showed that a 1 mmol/L increment in Lac was associated with 0.24 times higher risk of 30-day mortality [odds ratio (OR) = 1.24, 95% confidence interval (95%CI) was 1.19-1.29, P < 0.000 1]. ROC curve analysis showed that the area under ROC curve (AUC) of 1 h Lac for predicting 30-day mortality of severe patients was 0.694 (95%CI was 0.669-0.718). The cut-off value was 3.35 mmol/L with sensitivity of 0.499 and specificity of 0.779, whilst positive likelihood ratio was 2.260, and negative likelihood ratio was 0.643. According to the cut-off value of 1 h Lac, the patients were divided into high lactate group (≥ 3.35 mmol/L) and low lactate group (< 3.35 mmol/L). In the two subgroups, 30-day mortality was 31.58% (336/1 064) and 11.60% (337/2 905), respectively. The Kaplan-Meier survival curve showed that the 30-day cumulative survival rate of high lactate group was significantly lower than that of low lactate group (Log-rank test: χ2 = 247.72, P < 0.000 1). Multiple Logistic regression analysis showed that the 30-day mortality rate of high lactate group was 2.34 times that the level of low lactate group (OR = 2.34, 95%CI was 1.90-2.88, P < 0.000 1), after the adjustment of age, time of admission, type of ICU, hemoglobin, leukocyte count, use of vasopressor, use of ventilator and main diagnosis of patients. Stratified analysis showed that the relationship between 1 h Lac and 30-day mortality was stable.1 h Lac is associated with 30-day mortality in critical care patients. The risk of death was significantly increased in critically ill patients with 1 h Lac higher than 3.35 mmol/L." @default.
• W3044994201 created "2020-07-29" @default.
• W3044994201 creator A5012179142 @default.
• W3044994201 creator A5045490892 @default.
• W3044994201 creator A5047458281 @default.
• W3044994201 creator A5058980858 @default.
• W3044994201 creator A5059158886 @default.
• W3044994201 creator A5091629889 @default.
• W3044994201 date "2020-06-01" @default.
• W3044994201 modified "2023-09-28" @default.
• W3044994201 title "[Relationship between 1-hour serum lactate level and 30-day mortality in critical care patients in intensive care unit]." @default.
• W3044994201 doi "https://doi.org/10.3760/cma.j.cn121430-20200116-00136" @default.
• W3044994201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32684223" @default.
• W3044994201 hasPublicationYear "2020" @default.
• W3044994201 type Work @default.
• W3044994201 sameAs 3044994201 @default.
• W3044994201 citedByCount "1" @default.
• W3044994201 countsByYear W30449942012023 @default.
• W3044994201 crossrefType "journal-article" @default.
• W3044994201 hasAuthorship W3044994201A5012179142 @default.
• W3044994201 hasAuthorship W3044994201A5045490892 @default.
• W3044994201 hasAuthorship W3044994201A5047458281 @default.
• W3044994201 hasAuthorship W3044994201A5058980858 @default.
• W3044994201 hasAuthorship W3044994201A5059158886 @default.
• W3044994201 hasAuthorship W3044994201A5091629889 @default.
• W3044994201 hasConcept C126322002 @default.
• W3044994201 hasConcept C151956035 @default.
• W3044994201 hasConcept C167135981 @default.
• W3044994201 hasConcept C177713679 @default.
• W3044994201 hasConcept C179755657 @default.
• W3044994201 hasConcept C2776376669 @default.
• W3044994201 hasConcept C2777465075 @default.
• W3044994201 hasConcept C2780306776 @default.
• W3044994201 hasConcept C2987404301 @default.
• W3044994201 hasConcept C58471807 @default.
• W3044994201 hasConcept C71924100 @default.
• W3044994201 hasConceptScore W3044994201C126322002 @default.
• W3044994201 hasConceptScore W3044994201C151956035 @default.
• W3044994201 hasConceptScore W3044994201C167135981 @default.
• W3044994201 hasConceptScore W3044994201C177713679 @default.
• W3044994201 hasConceptScore W3044994201C179755657 @default.
• W3044994201 hasConceptScore W3044994201C2776376669 @default.
• W3044994201 hasConceptScore W3044994201C2777465075 @default.
• W3044994201 hasConceptScore W3044994201C2780306776 @default.
• W3044994201 hasConceptScore W3044994201C2987404301 @default.
• W3044994201 hasConceptScore W3044994201C58471807 @default.
• W3044994201 hasConceptScore W3044994201C71924100 @default.
• W3044994201 hasIssue "6" @default.
• W3044994201 hasLocation W30449942011 @default.
• W3044994201 hasOpenAccess W3044994201 @default.
• W3044994201 hasPrimaryLocation W30449942011 @default.
• W3044994201 hasRelatedWork W1551601049 @default.
• W3044994201 hasRelatedWork W1980932576 @default.
• W3044994201 hasRelatedWork W1989960856 @default.
• W3044994201 hasRelatedWork W1997731007 @default.
• W3044994201 hasRelatedWork W2050412262 @default.
• W3044994201 hasRelatedWork W2073526851 @default.
• W3044994201 hasRelatedWork W2158654658 @default.
• W3044994201 hasRelatedWork W2411849792 @default.
• W3044994201 hasRelatedWork W3031320482 @default.
• W3044994201 hasRelatedWork W3197850556 @default.
• W3044994201 hasVolume "32" @default.
• W3044994201 isParatext "false" @default.
• W3044994201 isRetracted "false" @default.
• W3044994201 magId "3044994201" @default.
• W3044994201 workType "article" @default.