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- W3045005847 abstract "Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher NEP content and/or activity compared with any other organ; 2) NEP seems to be downregulated under HF conditions; and 3) that the value of plasma NEP concentrations and activity as biomarkers is questionable. For the first time, these data provide basic knowledge on HF-related pathophysiological alterations of the NEP system and contribute to understanding the mechanism of action of angiotensin-receptor neprilysin-inhibitors, which remains elusive despite broad clinical applications." @default.
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- W3045005847 date "2020-07-01" @default.
- W3045005847 modified "2023-10-18" @default.
- W3045005847 title "Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation" @default.
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- W3045005847 doi "https://doi.org/10.1016/j.jacbts.2020.05.011" @default.
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