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• W3045018055 abstract "Coral-derived microorganisms have been historically proven to be prolific sources of bioactive secondary metabolites. Twelve benzopyranone and/or xanthone derivatives, including a new benzopyranone with an uncommon carboxyl group at C-8, coniochaetone K (1), were obtained from the Beibu Gulf-derived coral symbiotic fungus Cladosporium halotolerans GXIMD 02502. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature values. The absolute configuration of 1 was accomplished by comparison of specific optical rotation as well as quantum chemical ECD calculations. The in vitro cytotoxicity of compounds 1-12 against two human prostatic cancer cell lines, C4-2B and 22RV1, were evaluated. And compounds 1, 3, 6-8, and 10-11 demonstrated significant cytotoxicity with inhibitions ranging from 55.8% to 82.1% at the concentration of 10 μM." @default.
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• W3045018055 date "2020-07-27" @default.
• W3045018055 modified "2023-09-30" @default.
• W3045018055 title "Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus <i>Cladosporium halotolerans</i> GXIMD 02502" @default.
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• W3045018055 doi "https://doi.org/10.1080/14786419.2020.1799363" @default.
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