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• W3045040003 endingPage "1435" @default.
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• W3045040003 abstract "Introduction Most new drug candidates under development are poorly water-soluble, which are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by the improvement of solubility/dissolution has become a major concern to develop efficacious drugs with reasonable dosing regimens for patients. Over the past decade, increasing reports have been published on the investigation of co-amorphous drug delivery systems, with positive and excited outcomes in improving in vitro and in vivo performances of poorly water-soluble drugs.Areas covered This review summarizes recent findings of co-amorphous systems and provides their updates as a comprehensive overview in terms of classification, co-formers selection, preparation methods, physicochemical characteristics and in vivo performances.Expert opinion Co-amorphous system, a homogeneous single-phase system containing two compatible drugs or a drug with a pharmaceutically acceptable small-molecule co-former, has been employed as a promising formulation technology to improve in vitro and in vivo performances of poorly water-soluble drugs such as solubility/dissolution, stability, mechanical properties and bioavailability. Furthermore, a deeper understanding of co-amorphous systems, including its detailed classification, the criteria of co-former selection, stability mechanisms and the faced challenges as well as perspectives, will be more conducive to its development and application." @default.
• W3045040003 created "2020-07-29" @default.
• W3045040003 creator A5023172582 @default.
• W3045040003 creator A5024457019 @default.
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• W3045040003 creator A5077204577 @default.
• W3045040003 creator A5079128389 @default.
• W3045040003 creator A5082032178 @default.
• W3045040003 date "2020-09-17" @default.
• W3045040003 modified "2023-10-14" @default.
• W3045040003 title "Co-amorphous systems for the delivery of poorly water-soluble drugs: recent advances and an update" @default.
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