Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045051142> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3045051142 endingPage "128957" @default.
- W3045051142 startingPage "128957" @default.
- W3045051142 abstract "Glutamine: fructose-6-phosphate aminotransferase (GFAT) is the first and rate-limiting enzyme in the hexosamine biosynthetic pathway, which plays an important role in type 2 diabetes. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate. Recent findings indicate that the flux through the hexosamine pathway, regulated by GFAT, is responsible for the development of diabetic vascular diseases, particularly diabetic nephropathy. Therefore, this enzyme is a therapeutic target for control of type 2 diabetes and the complications caused by the disease. Black rice bran contains many bioactive compounds and previous studies have shown that the black rice bran extract (BRBE) can decrease glucose levels in diabetic rats. Among the phenolic compounds, cyanidin-3-O-glucoside (COG) is the major anthocyanin in black rice. To elucidate the mechanism of antidiabetic effect of BRBE, the present study was designed to evaluate molecular interactions existing between six bioactive compounds extracted from black rice (Oryza sativa L.) viz. Cyanadin-3-O-Glucoside (COG), 6´-O-Feruloylsucrose (FLS), p-Coumaric acid (pCmA), Syringic acid (SYA), Sinapic acid (SPA) and Protocatechuic acid (PCA) with GFAT enzyme. The results indicated that of all the compounds extracted from black rice, COG and FLS show greater binding affinity than the native ligand glucose-6-phosphate. The other components of black rice also show a comparable binding affinity with the receptor. Thus the compounds extracted from black rice may produce significant antidiabetic effect by binding with GFAT." @default.
- W3045051142 created "2020-07-29" @default.
- W3045051142 creator A5046078285 @default.
- W3045051142 creator A5055128302 @default.
- W3045051142 creator A5057011054 @default.
- W3045051142 creator A5061563652 @default.
- W3045051142 creator A5087418205 @default.
- W3045051142 date "2020-12-01" @default.
- W3045051142 modified "2023-09-27" @default.
- W3045051142 title "Glutamine: Fructose-6-phosphate aminotransferase (GFAT) inhibitory activity of the anthocyanins present in black rice bran: a probable mechanism for the anti diabetic effect" @default.
- W3045051142 cites W1500663067 @default.
- W3045051142 cites W1590732591 @default.
- W3045051142 cites W1964888552 @default.
- W3045051142 cites W1982355723 @default.
- W3045051142 cites W2003902631 @default.
- W3045051142 cites W2008128312 @default.
- W3045051142 cites W2105731956 @default.
- W3045051142 cites W2106371385 @default.
- W3045051142 cites W2116979101 @default.
- W3045051142 cites W2124488542 @default.
- W3045051142 cites W2124558473 @default.
- W3045051142 cites W2148359238 @default.
- W3045051142 cites W2156849498 @default.
- W3045051142 cites W2159251461 @default.
- W3045051142 cites W2273614087 @default.
- W3045051142 cites W2414292345 @default.
- W3045051142 cites W2518538586 @default.
- W3045051142 cites W2524546610 @default.
- W3045051142 cites W2555536206 @default.
- W3045051142 cites W2789631475 @default.
- W3045051142 cites W2886516991 @default.
- W3045051142 cites W2888821637 @default.
- W3045051142 cites W2943698440 @default.
- W3045051142 doi "https://doi.org/10.1016/j.molstruc.2020.128957" @default.
- W3045051142 hasPublicationYear "2020" @default.
- W3045051142 type Work @default.
- W3045051142 sameAs 3045051142 @default.
- W3045051142 citedByCount "0" @default.
- W3045051142 crossrefType "journal-article" @default.
- W3045051142 hasAuthorship W3045051142A5046078285 @default.
- W3045051142 hasAuthorship W3045051142A5055128302 @default.
- W3045051142 hasAuthorship W3045051142A5057011054 @default.
- W3045051142 hasAuthorship W3045051142A5061563652 @default.
- W3045051142 hasAuthorship W3045051142A5087418205 @default.
- W3045051142 hasConcept C178790620 @default.
- W3045051142 hasConcept C181199279 @default.
- W3045051142 hasConcept C185592680 @default.
- W3045051142 hasConcept C206139338 @default.
- W3045051142 hasConcept C2776873940 @default.
- W3045051142 hasConcept C2776970464 @default.
- W3045051142 hasConcept C2778004101 @default.
- W3045051142 hasConcept C2778643407 @default.
- W3045051142 hasConcept C2781203734 @default.
- W3045051142 hasConcept C55493867 @default.
- W3045051142 hasConceptScore W3045051142C178790620 @default.
- W3045051142 hasConceptScore W3045051142C181199279 @default.
- W3045051142 hasConceptScore W3045051142C185592680 @default.
- W3045051142 hasConceptScore W3045051142C206139338 @default.
- W3045051142 hasConceptScore W3045051142C2776873940 @default.
- W3045051142 hasConceptScore W3045051142C2776970464 @default.
- W3045051142 hasConceptScore W3045051142C2778004101 @default.
- W3045051142 hasConceptScore W3045051142C2778643407 @default.
- W3045051142 hasConceptScore W3045051142C2781203734 @default.
- W3045051142 hasConceptScore W3045051142C55493867 @default.
- W3045051142 hasLocation W30450511421 @default.
- W3045051142 hasOpenAccess W3045051142 @default.
- W3045051142 hasPrimaryLocation W30450511421 @default.
- W3045051142 hasRelatedWork W1985958494 @default.
- W3045051142 hasRelatedWork W2029289790 @default.
- W3045051142 hasRelatedWork W2041275422 @default.
- W3045051142 hasRelatedWork W2042097357 @default.
- W3045051142 hasRelatedWork W2047806852 @default.
- W3045051142 hasRelatedWork W2048642571 @default.
- W3045051142 hasRelatedWork W2074675460 @default.
- W3045051142 hasRelatedWork W2139771291 @default.
- W3045051142 hasRelatedWork W2166258356 @default.
- W3045051142 hasRelatedWork W2739218254 @default.
- W3045051142 hasVolume "1222" @default.
- W3045051142 isParatext "false" @default.
- W3045051142 isRetracted "false" @default.
- W3045051142 magId "3045051142" @default.
- W3045051142 workType "article" @default.