Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045075737> ?p ?o ?g. }
- W3045075737 endingPage "e04502" @default.
- W3045075737 startingPage "e04502" @default.
- W3045075737 abstract "The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one of the targeted approach. Although, designing and developing a panel of new drugs molecules are always encouraged. However, in the current emergency, drug repurposing study is one of the most effective and fast track option. The crystal structure of a SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) RNA Dependent RNA Polymerase (RdRp) has recently been deciphered through X-ray crystallography. The single-chain of core RNA Dependent RNA Polymerase relies on virus-encoded cofactors nsp7 and two units of nsp8 for its optimum function. This study explored the FDA approved database of 7922 molecules and screened against the core polymerase along with cofactors. Here we report a panel of FDA approved drugs that show substantial interactions with key amino acid residues of the active site. Interestingly, some of the identified drugs (Ornipressin, Lypressin, Examorelin, Polymyxin B1) bind strongly within the binding pockets of both forms of RdRp. Besides, we found strong candidates for the complex form as well which include Nacortocin, Cistinexine, Cisatracurium (among others). These drugs have the potential to be considered while contriving therapeutic options." @default.
- W3045075737 created "2020-07-29" @default.
- W3045075737 creator A5033868776 @default.
- W3045075737 creator A5038263196 @default.
- W3045075737 creator A5067707625 @default.
- W3045075737 creator A5068235676 @default.
- W3045075737 creator A5084310113 @default.
- W3045075737 date "2020-07-01" @default.
- W3045075737 modified "2023-10-12" @default.
- W3045075737 title "SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study" @default.
- W3045075737 cites W124747732 @default.
- W3045075737 cites W1925205850 @default.
- W3045075737 cites W1966702780 @default.
- W3045075737 cites W1973161154 @default.
- W3045075737 cites W1973648815 @default.
- W3045075737 cites W1979217854 @default.
- W3045075737 cites W1985588649 @default.
- W3045075737 cites W1986006871 @default.
- W3045075737 cites W2009423060 @default.
- W3045075737 cites W2027316762 @default.
- W3045075737 cites W2027423337 @default.
- W3045075737 cites W2031168104 @default.
- W3045075737 cites W2041189078 @default.
- W3045075737 cites W2044453886 @default.
- W3045075737 cites W2057900261 @default.
- W3045075737 cites W2057910314 @default.
- W3045075737 cites W2076790509 @default.
- W3045075737 cites W2084698452 @default.
- W3045075737 cites W2086186867 @default.
- W3045075737 cites W2107050135 @default.
- W3045075737 cites W2116218816 @default.
- W3045075737 cites W2117795567 @default.
- W3045075737 cites W2118244185 @default.
- W3045075737 cites W2124996394 @default.
- W3045075737 cites W2140943911 @default.
- W3045075737 cites W2141802266 @default.
- W3045075737 cites W2143127665 @default.
- W3045075737 cites W2143788821 @default.
- W3045075737 cites W2144535748 @default.
- W3045075737 cites W2156615418 @default.
- W3045075737 cites W2161229311 @default.
- W3045075737 cites W2165616693 @default.
- W3045075737 cites W2171421171 @default.
- W3045075737 cites W2188673922 @default.
- W3045075737 cites W2238100083 @default.
- W3045075737 cites W2316265937 @default.
- W3045075737 cites W2333251233 @default.
- W3045075737 cites W2513547424 @default.
- W3045075737 cites W2896002881 @default.
- W3045075737 cites W2903939917 @default.
- W3045075737 cites W2914796231 @default.
- W3045075737 cites W2966001763 @default.
- W3045075737 cites W2995188607 @default.
- W3045075737 cites W3004896487 @default.
- W3045075737 cites W3006026504 @default.
- W3045075737 cites W3007227604 @default.
- W3045075737 cites W3008047170 @default.
- W3045075737 cites W3009655369 @default.
- W3045075737 cites W3012492786 @default.
- W3045075737 cites W3012550011 @default.
- W3045075737 cites W3012588029 @default.
- W3045075737 cites W3013198879 @default.
- W3045075737 cites W3013468691 @default.
- W3045075737 cites W3102902405 @default.
- W3045075737 cites W4252867427 @default.
- W3045075737 doi "https://doi.org/10.1016/j.heliyon.2020.e04502" @default.
- W3045075737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7377705" @default.
- W3045075737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32754651" @default.
- W3045075737 hasPublicationYear "2020" @default.
- W3045075737 type Work @default.
- W3045075737 sameAs 3045075737 @default.
- W3045075737 citedByCount "71" @default.
- W3045075737 countsByYear W30450757372020 @default.
- W3045075737 countsByYear W30450757372021 @default.
- W3045075737 countsByYear W30450757372022 @default.
- W3045075737 countsByYear W30450757372023 @default.
- W3045075737 crossrefType "journal-article" @default.
- W3045075737 hasAuthorship W3045075737A5033868776 @default.
- W3045075737 hasAuthorship W3045075737A5038263196 @default.
- W3045075737 hasAuthorship W3045075737A5067707625 @default.
- W3045075737 hasAuthorship W3045075737A5068235676 @default.
- W3045075737 hasAuthorship W3045075737A5084310113 @default.
- W3045075737 hasBestOaLocation W30450757371 @default.
- W3045075737 hasConcept C103637391 @default.
- W3045075737 hasConcept C104317684 @default.
- W3045075737 hasConcept C159047783 @default.
- W3045075737 hasConcept C181199279 @default.
- W3045075737 hasConcept C18903297 @default.
- W3045075737 hasConcept C2776449523 @default.
- W3045075737 hasConcept C2780035454 @default.
- W3045075737 hasConcept C41258723 @default.
- W3045075737 hasConcept C519536355 @default.
- W3045075737 hasConcept C55493867 @default.
- W3045075737 hasConcept C67705224 @default.
- W3045075737 hasConcept C70721500 @default.
- W3045075737 hasConcept C82381507 @default.
- W3045075737 hasConcept C86803240 @default.
- W3045075737 hasConcept C98274493 @default.