FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045107212> ?p ?o ?g. }

• W3045107212 endingPage "1384" @default.
• W3045107212 startingPage "1377" @default.
• W3045107212 abstract "Objective Caffeine, one of the most widely consumed products in the world, seems to interact with multiple components of the immune system by acting as a non-specific phosphodiesterase inhibitor. In vitro dose-dependent treatment with caffeine down-regulates mRNA levels of key inflammation-related genes in peripheral blood mononuclear cells. So far, no robust data are available about the possible contribution of caffeine in systemic lupus erythematosus (SLE). The aim of this study was to evaluate the impact of caffeine consumption on SLE-related disease phenotype and activity, in terms of clinimetric assessment and cytokine serum levels. Methods We performed a cross-sectional study, enrolling consecutive patients and reporting their clinical and laboratory data. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2K). Caffeine intake was evaluated by a 7-day food frequency questionnaire, including all the main sources of caffeine. As previously reported, patients were divided into four groups according to the daily caffeine intake: <29.1 mg/day (group 1), 29.2–153.7 mg/day (group 2), 153.8–376.5 mg/day (group 3) and >376.6 mg/day (group 4). At the end of questionnaire filling, blood samples were collected from each patient to assess cytokine levels. These were assessed by using a panel by Bio-Plex assays to measure the levels of IL-6, IL-10, IL-17, IL-27, IFNγ, IFNα and BLyS. Results We enrolled 89 consecutive SLE patients. We observed a negative correlation between caffeine consumption and disease activity, measured with SLEDAI-2K. A significantly higher prevalence of lupus nephritis, neuropsychiatric involvement, haematological manifestations, hypocomplementaemia and anti-dsDNA positivity was observed in patients with a low intake of caffeine. Furthermore, patients with a low intake of caffeine were more frequently treated with glucocorticoids. Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNγ was found ( p = 0.03, r = –0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNα ( p = 0.02), IL-17 ( p = 0.01) and IL-6 ( p = 0.003). Conclusions In this report we demonstrated the impact of caffeine on SLE disease activity status, as confirmed by the inverse correlation between its intake and both SLEDAI-2K values and cytokine levels. Moreover, patients with a low caffeine consumption seem to have a more severe disease phenotype." @default.
• W3045107212 created "2020-07-29" @default.
• W3045107212 creator A5004485732 @default.
• W3045107212 creator A5007786878 @default.
• W3045107212 creator A5018233887 @default.
• W3045107212 creator A5034918533 @default.
• W3045107212 creator A5051526168 @default.
• W3045107212 creator A5063498618 @default.
• W3045107212 creator A5066620429 @default.
• W3045107212 creator A5068896566 @default.
• W3045107212 creator A5083687141 @default.
• W3045107212 creator A5084835799 @default.
• W3045107212 creator A5087114501 @default.
• W3045107212 creator A5089912115 @default.
• W3045107212 date "2020-07-23" @default.
• W3045107212 modified "2023-10-18" @default.
• W3045107212 title "Caffeine intake influences disease activity and clinical phenotype in systemic lupus erythematosus patients" @default.
• W3045107212 cites W1590102401 @default.
• W3045107212 cites W1642392901 @default.
• W3045107212 cites W1905122931 @default.
• W3045107212 cites W1930962503 @default.
• W3045107212 cites W1972616962 @default.
• W3045107212 cites W1976026635 @default.
• W3045107212 cites W1988227555 @default.
• W3045107212 cites W1994970739 @default.
• W3045107212 cites W1995845116 @default.
• W3045107212 cites W1996725867 @default.
• W3045107212 cites W2005278031 @default.
• W3045107212 cites W2011731486 @default.
• W3045107212 cites W2016036161 @default.
• W3045107212 cites W2017035402 @default.
• W3045107212 cites W2019348446 @default.
• W3045107212 cites W2022599378 @default.
• W3045107212 cites W2056908285 @default.
• W3045107212 cites W2057407878 @default.
• W3045107212 cites W2065907531 @default.
• W3045107212 cites W2070391335 @default.
• W3045107212 cites W2070527591 @default.
• W3045107212 cites W2078327260 @default.
• W3045107212 cites W2078660855 @default.
• W3045107212 cites W2079461506 @default.
• W3045107212 cites W2083865586 @default.
• W3045107212 cites W2089396126 @default.
• W3045107212 cites W2106273198 @default.
• W3045107212 cites W2111151054 @default.
• W3045107212 cites W2112839007 @default.
• W3045107212 cites W2114235313 @default.
• W3045107212 cites W2149480249 @default.
• W3045107212 cites W2153171315 @default.
• W3045107212 cites W2168888135 @default.
• W3045107212 cites W2213492109 @default.
• W3045107212 cites W2337862268 @default.
• W3045107212 cites W2413790285 @default.
• W3045107212 cites W2486559230 @default.
• W3045107212 cites W2551404503 @default.
• W3045107212 cites W2604449501 @default.
• W3045107212 cites W2606312008 @default.
• W3045107212 cites W2611942778 @default.
• W3045107212 cites W2647766511 @default.
• W3045107212 cites W2751900542 @default.
• W3045107212 cites W2800846663 @default.
• W3045107212 cites W2888668952 @default.
• W3045107212 doi "https://doi.org/10.1177/0961203320941920" @default.
• W3045107212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32703116" @default.
• W3045107212 hasPublicationYear "2020" @default.
• W3045107212 type Work @default.
• W3045107212 sameAs 3045107212 @default.
• W3045107212 citedByCount "5" @default.
• W3045107212 countsByYear W30451072122020 @default.
• W3045107212 countsByYear W30451072122022 @default.
• W3045107212 countsByYear W30451072122023 @default.
• W3045107212 crossrefType "journal-article" @default.
• W3045107212 hasAuthorship W3045107212A5004485732 @default.
• W3045107212 hasAuthorship W3045107212A5007786878 @default.
• W3045107212 hasAuthorship W3045107212A5018233887 @default.
• W3045107212 hasAuthorship W3045107212A5034918533 @default.
• W3045107212 hasAuthorship W3045107212A5051526168 @default.
• W3045107212 hasAuthorship W3045107212A5063498618 @default.
• W3045107212 hasAuthorship W3045107212A5066620429 @default.
• W3045107212 hasAuthorship W3045107212A5068896566 @default.
• W3045107212 hasAuthorship W3045107212A5083687141 @default.
• W3045107212 hasAuthorship W3045107212A5084835799 @default.
• W3045107212 hasAuthorship W3045107212A5087114501 @default.
• W3045107212 hasAuthorship W3045107212A5089912115 @default.
• W3045107212 hasConcept C126322002 @default.
• W3045107212 hasConcept C137061746 @default.
• W3045107212 hasConcept C185592680 @default.
• W3045107212 hasConcept C202751555 @default.
• W3045107212 hasConcept C203014093 @default.
• W3045107212 hasConcept C2776912625 @default.
• W3045107212 hasConcept C2778500429 @default.
• W3045107212 hasConcept C2778690821 @default.
• W3045107212 hasConcept C2779134260 @default.
• W3045107212 hasConcept C42407357 @default.
• W3045107212 hasConcept C55493867 @default.
• W3045107212 hasConcept C71924100 @default.
• W3045107212 hasConcept C8891405 @default.
• W3045107212 hasConcept C90924648 @default.

• next