Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045160064> ?p ?o ?g. }
- W3045160064 endingPage "1615" @default.
- W3045160064 startingPage "1606" @default.
- W3045160064 abstract "Abstract Osteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions. The Hippo signalling pathway regulates cell and tissue growth by modulating cell proliferation, differentiation, and migration in developing organs. Mammalian STE20‐like 1/2 (MST1/2) protein kinases are activated by neurofibromatosis type 2, Ras association domain family member 2, kidney and brain protein, or other factors. Interactions between MST1/2 and salvador family WW domain‐containing protein 1 activate large tumour suppressor kinase 1/2 proteins, which in turn phosphorylate the downstream Yes‐associated protein 1/transcriptional coactivator with PDZ‐binding motif (YAP/TAZ). Moreover, dysregulation of this pathway can lead to aberrant cell growth, resulting in tumorigenesis. Interestingly, small molecules targeting the Hippo signalling pathways, through affecting YAP/TAZ cellular localisation and their interaction with members of the TEA/ATTS domain family of transcriptional enhancers are being developed and hold promise for the treatment of OS. This review discusses the existing knowledge about the involvement of the Hippo signalling cascade in OS and highlights several small molecule inhibitors as potential novel therapeutics." @default.
- W3045160064 created "2020-07-29" @default.
- W3045160064 creator A5005403182 @default.
- W3045160064 creator A5012767609 @default.
- W3045160064 creator A5041796206 @default.
- W3045160064 creator A5049040189 @default.
- W3045160064 creator A5056932776 @default.
- W3045160064 creator A5065172118 @default.
- W3045160064 date "2020-07-22" @default.
- W3045160064 modified "2023-10-15" @default.
- W3045160064 title "The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies" @default.
- W3045160064 cites W148329645 @default.
- W3045160064 cites W1925213563 @default.
- W3045160064 cites W1965057978 @default.
- W3045160064 cites W1976571762 @default.
- W3045160064 cites W1979312360 @default.
- W3045160064 cites W1980860406 @default.
- W3045160064 cites W1983055513 @default.
- W3045160064 cites W2006778392 @default.
- W3045160064 cites W2013935331 @default.
- W3045160064 cites W2031241881 @default.
- W3045160064 cites W2036881415 @default.
- W3045160064 cites W2062609656 @default.
- W3045160064 cites W2066812797 @default.
- W3045160064 cites W2075441384 @default.
- W3045160064 cites W2099802056 @default.
- W3045160064 cites W2104234534 @default.
- W3045160064 cites W2114427673 @default.
- W3045160064 cites W2120735426 @default.
- W3045160064 cites W2125091346 @default.
- W3045160064 cites W2127325055 @default.
- W3045160064 cites W2132264180 @default.
- W3045160064 cites W2143697753 @default.
- W3045160064 cites W2148855636 @default.
- W3045160064 cites W2157931818 @default.
- W3045160064 cites W2173710913 @default.
- W3045160064 cites W2292856360 @default.
- W3045160064 cites W2342619391 @default.
- W3045160064 cites W2399488950 @default.
- W3045160064 cites W2496850373 @default.
- W3045160064 cites W2507621188 @default.
- W3045160064 cites W2513389093 @default.
- W3045160064 cites W2519377734 @default.
- W3045160064 cites W2548552592 @default.
- W3045160064 cites W2568514472 @default.
- W3045160064 cites W2568579857 @default.
- W3045160064 cites W2593160402 @default.
- W3045160064 cites W2597686565 @default.
- W3045160064 cites W2600392992 @default.
- W3045160064 cites W2611669040 @default.
- W3045160064 cites W2743455139 @default.
- W3045160064 cites W2769864773 @default.
- W3045160064 cites W2775217148 @default.
- W3045160064 cites W2793358208 @default.
- W3045160064 cites W2795462196 @default.
- W3045160064 cites W2799281626 @default.
- W3045160064 cites W2807171587 @default.
- W3045160064 cites W2888406284 @default.
- W3045160064 cites W2891363625 @default.
- W3045160064 cites W2899655237 @default.
- W3045160064 cites W2910993836 @default.
- W3045160064 cites W2919496582 @default.
- W3045160064 cites W2954828863 @default.
- W3045160064 cites W2972651928 @default.
- W3045160064 cites W2987124337 @default.
- W3045160064 cites W2992292488 @default.
- W3045160064 cites W2997362479 @default.
- W3045160064 cites W3003757839 @default.
- W3045160064 cites W3010441270 @default.
- W3045160064 cites W3012116403 @default.
- W3045160064 cites W834352309 @default.
- W3045160064 cites W896084183 @default.
- W3045160064 doi "https://doi.org/10.1002/jcp.29967" @default.
- W3045160064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32697358" @default.
- W3045160064 hasPublicationYear "2020" @default.
- W3045160064 type Work @default.
- W3045160064 sameAs 3045160064 @default.
- W3045160064 citedByCount "13" @default.
- W3045160064 countsByYear W30451600642021 @default.
- W3045160064 countsByYear W30451600642022 @default.
- W3045160064 countsByYear W30451600642023 @default.
- W3045160064 crossrefType "journal-article" @default.
- W3045160064 hasAuthorship W3045160064A5005403182 @default.
- W3045160064 hasAuthorship W3045160064A5012767609 @default.
- W3045160064 hasAuthorship W3045160064A5041796206 @default.
- W3045160064 hasAuthorship W3045160064A5049040189 @default.
- W3045160064 hasAuthorship W3045160064A5056932776 @default.
- W3045160064 hasAuthorship W3045160064A5065172118 @default.
- W3045160064 hasConcept C104317684 @default.
- W3045160064 hasConcept C121608353 @default.
- W3045160064 hasConcept C172512520 @default.
- W3045160064 hasConcept C179185449 @default.
- W3045160064 hasConcept C184235292 @default.
- W3045160064 hasConcept C204491159 @default.
- W3045160064 hasConcept C2777736865 @default.
- W3045160064 hasConcept C502942594 @default.
- W3045160064 hasConcept C54355233 @default.
- W3045160064 hasConcept C555283112 @default.