FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045176167> ?p ?o ?g. }

• W3045176167 endingPage "415" @default.
• W3045176167 startingPage "403" @default.
• W3045176167 abstract "Renal impairment (RI) is known to influence the pharmacokinetics of nonrenally eliminated drugs, although the mechanism and clinical impact is poorly understood. We assessed the impact of RI and single dose oral rifampin (RIF) on the pharmacokinetics of CYP3A, OATP1B, P‐gp, and BCRP substrates using a microdose cocktail and OATP1B endogenous biomarkers. RI alone had no impact on midazolam (MDZ), maximum plasma concentration (C max ), and area under the curve (AUC), but a progressive increase in AUC with RI severity for dabigatran (DABI), and up to ~2‐fold higher AUC for pitavastatin (PTV), rosuvastatin (RSV), and atorvastatin (ATV) for all degrees of RI was observed. RIF did not impact MDZ, had a progressively smaller DABI drug‐drug interaction (DDI) with increasing RI severity, a similar 3.1‐fold to 4.4‐fold increase in PTV and RSV AUC in healthy volunteers and patients with RI, and a diminishing DDI with RI severity from 6.1‐fold to 4.7‐fold for ATV. Endogenous biomarkers of OATP1B (bilirubin, coproporphyrin I/III, and sulfated bile salts) were generally not impacted by RI, and RIF effects on these biomarkers in RI were comparable or larger than those in healthy volunteers. The lack of a trend with RI severity of PTV and several OATP1B biomarkers, suggests that mechanisms beyond RI directly impacting OATP1B activity could also be considered. The DABI, RSV, and ATV data suggest an impact of RI on intestinal P‐gp, and potentially BCRP activity. Therefore, DDI data from healthy volunteers may represent a worst‐case scenario for clinically derisking P‐gp and BCRP substrates in the setting of RI." @default.
• W3045176167 created "2020-07-29" @default.
• W3045176167 creator A5004147994 @default.
• W3045176167 creator A5010246066 @default.
• W3045176167 creator A5011543465 @default.
• W3045176167 creator A5013234560 @default.
• W3045176167 creator A5015505110 @default.
• W3045176167 creator A5020664489 @default.
• W3045176167 creator A5024345070 @default.
• W3045176167 creator A5028366409 @default.
• W3045176167 creator A5031801246 @default.
• W3045176167 creator A5037608156 @default.
• W3045176167 creator A5048351488 @default.
• W3045176167 creator A5059043247 @default.
• W3045176167 creator A5061427649 @default.
• W3045176167 creator A5064222916 @default.
• W3045176167 creator A5066154146 @default.
• W3045176167 creator A5067691892 @default.
• W3045176167 creator A5068612795 @default.
• W3045176167 creator A5075517089 @default.
• W3045176167 creator A5079039131 @default.
• W3045176167 creator A5080292677 @default.
• W3045176167 creator A5082048814 @default.
• W3045176167 creator A5087660192 @default.
• W3045176167 creator A5087795618 @default.
• W3045176167 creator A5088130903 @default.
• W3045176167 date "2020-10-26" @default.
• W3045176167 modified "2023-10-09" @default.
• W3045176167 title "A Microdose Cocktail to Evaluate Drug Interactions in Patients with Renal Impairment" @default.
• W3045176167 cites W1587492601 @default.
• W3045176167 cites W1926627776 @default.
• W3045176167 cites W1973792425 @default.
• W3045176167 cites W2006370287 @default.
• W3045176167 cites W2018962781 @default.
• W3045176167 cites W2050440877 @default.
• W3045176167 cites W2051485840 @default.
• W3045176167 cites W2078946004 @default.
• W3045176167 cites W2086423324 @default.
• W3045176167 cites W2088270471 @default.
• W3045176167 cites W2110287784 @default.
• W3045176167 cites W2122231873 @default.
• W3045176167 cites W2122481820 @default.
• W3045176167 cites W2131138924 @default.
• W3045176167 cites W2131983256 @default.
• W3045176167 cites W2141941946 @default.
• W3045176167 cites W2146949579 @default.
• W3045176167 cites W2152218609 @default.
• W3045176167 cites W2152923211 @default.
• W3045176167 cites W2304200208 @default.
• W3045176167 cites W2495572230 @default.
• W3045176167 cites W2502300957 @default.
• W3045176167 cites W2560564128 @default.
• W3045176167 cites W2594985910 @default.
• W3045176167 cites W2605527602 @default.
• W3045176167 cites W2616878580 @default.
• W3045176167 cites W2619811860 @default.
• W3045176167 cites W2623484206 @default.
• W3045176167 cites W2761667289 @default.
• W3045176167 cites W2783756307 @default.
• W3045176167 cites W2799486834 @default.
• W3045176167 cites W2886788587 @default.
• W3045176167 cites W2891442347 @default.
• W3045176167 cites W2892311631 @default.
• W3045176167 cites W2896835015 @default.
• W3045176167 cites W2910326983 @default.
• W3045176167 cites W2935303859 @default.
• W3045176167 cites W2938446497 @default.
• W3045176167 cites W2967711612 @default.
• W3045176167 doi "https://doi.org/10.1002/cpt.1998" @default.
• W3045176167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32705692" @default.
• W3045176167 hasPublicationYear "2020" @default.
• W3045176167 type Work @default.
• W3045176167 sameAs 3045176167 @default.
• W3045176167 citedByCount "21" @default.
• W3045176167 countsByYear W30451761672021 @default.
• W3045176167 countsByYear W30451761672022 @default.
• W3045176167 countsByYear W30451761672023 @default.
• W3045176167 crossrefType "journal-article" @default.
• W3045176167 hasAuthorship W3045176167A5004147994 @default.
• W3045176167 hasAuthorship W3045176167A5010246066 @default.
• W3045176167 hasAuthorship W3045176167A5011543465 @default.
• W3045176167 hasAuthorship W3045176167A5013234560 @default.
• W3045176167 hasAuthorship W3045176167A5015505110 @default.
• W3045176167 hasAuthorship W3045176167A5020664489 @default.
• W3045176167 hasAuthorship W3045176167A5024345070 @default.
• W3045176167 hasAuthorship W3045176167A5028366409 @default.
• W3045176167 hasAuthorship W3045176167A5031801246 @default.
• W3045176167 hasAuthorship W3045176167A5037608156 @default.
• W3045176167 hasAuthorship W3045176167A5048351488 @default.
• W3045176167 hasAuthorship W3045176167A5059043247 @default.
• W3045176167 hasAuthorship W3045176167A5061427649 @default.
• W3045176167 hasAuthorship W3045176167A5064222916 @default.
• W3045176167 hasAuthorship W3045176167A5066154146 @default.
• W3045176167 hasAuthorship W3045176167A5067691892 @default.
• W3045176167 hasAuthorship W3045176167A5068612795 @default.
• W3045176167 hasAuthorship W3045176167A5075517089 @default.
• W3045176167 hasAuthorship W3045176167A5079039131 @default.
• W3045176167 hasAuthorship W3045176167A5080292677 @default.

• next