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• W3045185712 abstract "Abstract Interactions between cells drive biological processes across all of life, from microbes in the environment to cells in multicellular organisms. Interactions often arise in spatially structured settings, where cells mostly interact with their neighbors. A central question is how local interactions shape the properties of biological systems. This question is very relevant in the context of microbial communities, such as biofilms, where cells live close by in space and are connected via a dense network of biochemical interactions. To understand and control the functioning of these communities, it is essential to uncover how community-level properties, such as the community composition, spatial arrangement, and growth rate, arise from these interactions. Here, we develop a mathematical framework that can predict community-level properties from the molecular mechanisms underlying the cell-cell interactions for systems consisting of two cell types. Our predictions can qualitatively reproduce measurements from an experimental cross-feeding community. For these cross-feeding communities, the community growth rate is reduced when cells interact only with few neighbors; as a result, some communities can co-exist in a well-mixed system, where cells can interact with all other cells, but not in systems where cells can interact only with close by neighbors. In general, our framework shows that key molecular parameters underlying the cell-cell interactions (e.g. the uptake and leakage rates of molecules) determine community-level properties. Our framework can be extended to a variety of systems of two interacting cell types, within and beyond the microbial world, and contributes to our understanding of how community-level dynamics and biological functions emerge from microscopic interactions between single cells." @default.
• W3045185712 created "2020-07-29" @default.
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• W3045185712 date "2020-07-26" @default.
• W3045185712 modified "2023-10-18" @default.
• W3045185712 title "Global dynamics of microbial communities emerge from local interaction rules" @default.
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• W3045185712 doi "https://doi.org/10.1101/2020.07.25.220822" @default.
• W3045185712 hasPublicationYear "2020" @default.
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