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• W3045200907 abstract "Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were detected in the crown cells at the node. These Ca2+ transients showed L-R asymmetry, which was lost in the absence of fluid flow or the PKD2 channel. Further characterization allowed classification of the Ca2+ transients into two types: cilium-derived, L-R-asymmetric transients (type 1) and cilium-independent transients without an L-R bias (type 2). Type 1 intraciliary transients occurred preferentially at the left posterior region of the node, where L-R symmetry breaking takes place. Suppression of intraciliary Ca2+ transients delayed L-R symmetry breaking. Our results implicate cilium-derived Ca2+ transients in crown cells in initiation of L-R symmetry breaking in the mouse embryo." @default.
• W3045200907 created "2020-07-29" @default.
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• W3045200907 date "2020-07-24" @default.
• W3045200907 modified "2023-10-18" @default.
• W3045200907 title "Role of Ca ²⁺ transients at the node of the mouse embryo in breaking of left-right symmetry" @default.
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• W3045200907 doi "https://doi.org/10.1126/sciadv.aba1195" @default.
• W3045200907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7375832" @default.
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