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• W3045204612 endingPage "27" @default.
• W3045204612 startingPage "27" @default.
• W3045204612 abstract "Congenital cardiovascular malformation is a common birth defect incorporating abnormalities of the outflow tract and aortic arch arteries, and mice deficient in the transcription factor AP-2α (Tcfap2a) present with complex defects affecting these structures. AP-2α is expressed in the pharyngeal surface ectoderm and neural crest at mid-embryogenesis in the mouse, but the precise tissue compartment in which AP-2α is required for cardiovascular development has not been identified. In this study we describe the fully penetrant AP-2α deficient cardiovascular phenotype on a C57Bl/6J genetic background and show that this is associated with increased apoptosis in the pharyngeal ectoderm. Neural crest cell migration into the pharyngeal arches was not affected. Cre-expressing transgenic mice were used in conjunction with an AP-2α conditional allele to examine the effect of deleting AP-2α from the pharyngeal surface ectoderm and the neural crest, either individually or in combination, as well as the second heart field. This, surprisingly, was unable to fully recapitulate the global AP-2α deficient cardiovascular phenotype. The outflow tract and arch artery phenotype was, however, recapitulated through early embryonic Cre-mediated recombination. These findings indicate that AP-2α has a complex influence on cardiovascular development either being required very early in embryogenesis and/or having a redundant function in many tissue layers." @default.
• W3045204612 created "2020-07-29" @default.
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• W3045204612 date "2020-07-23" @default.
• W3045204612 modified "2023-10-17" @default.
• W3045204612 title "Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development" @default.
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• W3045204612 cites W1506409704 @default.
• W3045204612 cites W1520697307 @default.
• W3045204612 cites W1590222977 @default.
• W3045204612 cites W1768274470 @default.
• W3045204612 cites W1965215187 @default.
• W3045204612 cites W1966563415 @default.
• W3045204612 cites W1969779429 @default.
• W3045204612 cites W1974260249 @default.
• W3045204612 cites W1982204468 @default.
• W3045204612 cites W1993399270 @default.
• W3045204612 cites W1999244257 @default.
• W3045204612 cites W2002777789 @default.
• W3045204612 cites W2003426511 @default.
• W3045204612 cites W2007116888 @default.
• W3045204612 cites W2011480406 @default.
• W3045204612 cites W2017506108 @default.
• W3045204612 cites W2019993995 @default.
• W3045204612 cites W2020570800 @default.
• W3045204612 cites W2021052173 @default.
• W3045204612 cites W2021791638 @default.
• W3045204612 cites W2023956952 @default.
• W3045204612 cites W2025393360 @default.
• W3045204612 cites W2026478594 @default.
• W3045204612 cites W2028751450 @default.
• W3045204612 cites W2029294928 @default.
• W3045204612 cites W2029787649 @default.
• W3045204612 cites W2031305240 @default.
• W3045204612 cites W2031842244 @default.
• W3045204612 cites W2037601306 @default.
• W3045204612 cites W2040403266 @default.
• W3045204612 cites W2042875644 @default.
• W3045204612 cites W2046123790 @default.
• W3045204612 cites W2050184933 @default.
• W3045204612 cites W2050367709 @default.
• W3045204612 cites W2052575482 @default.
• W3045204612 cites W2053699349 @default.
• W3045204612 cites W2058702127 @default.
• W3045204612 cites W2059032864 @default.
• W3045204612 cites W2063143393 @default.
• W3045204612 cites W2063588906 @default.
• W3045204612 cites W2063989842 @default.
• W3045204612 cites W2065011422 @default.
• W3045204612 cites W2069126410 @default.
• W3045204612 cites W2079584632 @default.
• W3045204612 cites W2079978621 @default.
• W3045204612 cites W2083202289 @default.
• W3045204612 cites W2096418253 @default.
• W3045204612 cites W2096448056 @default.
• W3045204612 cites W2096999174 @default.
• W3045204612 cites W2097557608 @default.
• W3045204612 cites W2108136497 @default.
• W3045204612 cites W2109501842 @default.
• W3045204612 cites W2109627278 @default.
• W3045204612 cites W2111350290 @default.
• W3045204612 cites W2117360245 @default.
• W3045204612 cites W2119402894 @default.
• W3045204612 cites W2122329737 @default.
• W3045204612 cites W2127793385 @default.
• W3045204612 cites W2138071615 @default.
• W3045204612 cites W2139971039 @default.
• W3045204612 cites W2143242950 @default.
• W3045204612 cites W2154448714 @default.
• W3045204612 cites W2157592788 @default.
• W3045204612 cites W2265303794 @default.
• W3045204612 cites W2330527337 @default.
• W3045204612 cites W2337949001 @default.
• W3045204612 cites W2399889812 @default.
• W3045204612 cites W2481084357 @default.
• W3045204612 cites W2784701284 @default.
• W3045204612 cites W2901460107 @default.
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• W3045204612 doi "https://doi.org/10.3390/jcdd7030027" @default.
• W3045204612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7570199" @default.
• W3045204612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32717817" @default.
• W3045204612 hasPublicationYear "2020" @default.
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