Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045246503> ?p ?o ?g. }
- W3045246503 endingPage "1649" @default.
- W3045246503 startingPage "1638" @default.
- W3045246503 abstract "Abstract A method involving tandem activation of γ‐thiolactone by silver‐DABCO pair has been developed to enable successful amidation of homocysteine thiolactone by various amino acid residues and dipeptides with yields up to 95%. The introduction of thiol functionality to peptides directly using cysteine or homocysteine would require the protection of the reactive sulfhydryl groups and deprotection at a later stage of the synthesis. The γ‐thiolactone chemistry presented herein shows that it could serve as a masked and activatable reaction handle to prepare a range of thiol‐containing peptides in a more atom‐economical way. The resulting thiol‐containing peptides could facilitate late‐stage functionalization and structural diversification of functional or bioactive peptides. The silver(I) ion was found to be essential for the activation of the γ‐thiolactone, poor reactions were observed otherwise. A tentative mechanism for the silver‐DABCO promoted γ‐thiolactone aminolysis was proposed and supported by the evidence from thermal desorption electrospray ionization mass spectrometry." @default.
- W3045246503 created "2020-07-29" @default.
- W3045246503 creator A5010270371 @default.
- W3045246503 creator A5043102650 @default.
- W3045246503 creator A5051795168 @default.
- W3045246503 creator A5058534316 @default.
- W3045246503 creator A5065916611 @default.
- W3045246503 creator A5071357950 @default.
- W3045246503 date "2020-08-28" @default.
- W3045246503 modified "2023-10-14" @default.
- W3045246503 title "Synthesis of Thiol‐Containing Oligopeptides via Tandem Activation of γ‐Thiolactones by Silver‐DABCO Pair" @default.
- W3045246503 cites W1193657952 @default.
- W3045246503 cites W1486644147 @default.
- W3045246503 cites W1593983577 @default.
- W3045246503 cites W1859901295 @default.
- W3045246503 cites W1963683058 @default.
- W3045246503 cites W1963780761 @default.
- W3045246503 cites W1975502142 @default.
- W3045246503 cites W1976979246 @default.
- W3045246503 cites W1982052532 @default.
- W3045246503 cites W1982807734 @default.
- W3045246503 cites W1984609665 @default.
- W3045246503 cites W1990372683 @default.
- W3045246503 cites W1992450378 @default.
- W3045246503 cites W1994165491 @default.
- W3045246503 cites W1995141837 @default.
- W3045246503 cites W1997390193 @default.
- W3045246503 cites W2007009057 @default.
- W3045246503 cites W2010381072 @default.
- W3045246503 cites W2014209692 @default.
- W3045246503 cites W2017107688 @default.
- W3045246503 cites W2017564694 @default.
- W3045246503 cites W2018277210 @default.
- W3045246503 cites W2022952880 @default.
- W3045246503 cites W2025335666 @default.
- W3045246503 cites W2027076724 @default.
- W3045246503 cites W2031734182 @default.
- W3045246503 cites W2040764971 @default.
- W3045246503 cites W2050000500 @default.
- W3045246503 cites W2050556743 @default.
- W3045246503 cites W2051287793 @default.
- W3045246503 cites W2052037496 @default.
- W3045246503 cites W2055286364 @default.
- W3045246503 cites W2060846993 @default.
- W3045246503 cites W2066184790 @default.
- W3045246503 cites W2086662911 @default.
- W3045246503 cites W2088449919 @default.
- W3045246503 cites W2095886160 @default.
- W3045246503 cites W2104676217 @default.
- W3045246503 cites W2110251662 @default.
- W3045246503 cites W2125393811 @default.
- W3045246503 cites W2130112983 @default.
- W3045246503 cites W2153638129 @default.
- W3045246503 cites W2295408967 @default.
- W3045246503 cites W2297986624 @default.
- W3045246503 cites W2313538383 @default.
- W3045246503 cites W2318731154 @default.
- W3045246503 cites W2328108476 @default.
- W3045246503 cites W2334434412 @default.
- W3045246503 cites W2342150662 @default.
- W3045246503 cites W2345064040 @default.
- W3045246503 cites W2428476377 @default.
- W3045246503 cites W2492958735 @default.
- W3045246503 cites W2518896997 @default.
- W3045246503 cites W2523045592 @default.
- W3045246503 cites W2531319286 @default.
- W3045246503 cites W2557927788 @default.
- W3045246503 cites W2613163375 @default.
- W3045246503 cites W2626896450 @default.
- W3045246503 cites W2729329687 @default.
- W3045246503 cites W2771502367 @default.
- W3045246503 cites W2785142938 @default.
- W3045246503 cites W2789848362 @default.
- W3045246503 cites W2797593407 @default.
- W3045246503 cites W2888671356 @default.
- W3045246503 cites W2891588733 @default.
- W3045246503 cites W2915257949 @default.
- W3045246503 cites W2953301491 @default.
- W3045246503 cites W299054481 @default.
- W3045246503 cites W4253460708 @default.
- W3045246503 doi "https://doi.org/10.1002/ajoc.202000310" @default.
- W3045246503 hasPublicationYear "2020" @default.
- W3045246503 type Work @default.
- W3045246503 sameAs 3045246503 @default.
- W3045246503 citedByCount "2" @default.
- W3045246503 countsByYear W30452465032022 @default.
- W3045246503 crossrefType "journal-article" @default.
- W3045246503 hasAuthorship W3045246503A5010270371 @default.
- W3045246503 hasAuthorship W3045246503A5043102650 @default.
- W3045246503 hasAuthorship W3045246503A5051795168 @default.
- W3045246503 hasAuthorship W3045246503A5058534316 @default.
- W3045246503 hasAuthorship W3045246503A5065916611 @default.
- W3045246503 hasAuthorship W3045246503A5071357950 @default.
- W3045246503 hasConcept C145148216 @default.
- W3045246503 hasConcept C162356407 @default.
- W3045246503 hasConcept C178790620 @default.
- W3045246503 hasConcept C181199279 @default.
- W3045246503 hasConcept C185592680 @default.