FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045265280> ?p ?o ?g. }

• W3045265280 endingPage "237" @default.
• W3045265280 startingPage "226" @default.
• W3045265280 abstract "It is widely thought that the main reason for ovarian follicular atresia is apoptosis of granulosa cells, however, accumulating evidence suggests that autophagy plays a role in the fate of granulosa cells. Although epigenetic regulation including miR-21-3p associated with autophagy process has been reported in many cancer types, nevertheless, the mechanism of miR-21-3p in bovine ovary is poorly understood. In the present study, bovine ovarian granulosa cells (BGCs) were used as a model to elucidate the autophagy and role of miR-21-3p in a cattle ovary. The results from gene expression and tagged autophagosomes showed the autophagy in BGCs and miR-21-3p was identified as an important miRNA regulating autophagy of BGCs. The current results indicated that FGF2 was a validated target of miR-21-3p in autophagy regulation of BGCs according to the results from FGF2 luciferase reporter assays and FGF2 overexpression (oe-FGF2) or small interference (si-FGF2). Transfection of miR-21-3p mimic and si-FGF2 plasmids resulted in decreasing phosphorylated AKT and mTOR, while transfection of miR-21-3p inhibitor and oe-FGF2 increased the phosphorylated level of AKT and mTOR in BGCs. These data indicate that regulation of miR-21-3p on BGCs autophagy through AKT/mTOR pathway. In summary, this study suggests that miR-21-3p targets FGF2 to inhibit BGCs autophagy by repressing AKT/mTOR signaling." @default.
• W3045265280 created "2020-07-29" @default.
• W3045265280 creator A5010153439 @default.
• W3045265280 creator A5016385766 @default.
• W3045265280 creator A5027183173 @default.
• W3045265280 creator A5030672669 @default.
• W3045265280 creator A5046881277 @default.
• W3045265280 creator A5065973605 @default.
• W3045265280 date "2020-11-01" @default.
• W3045265280 modified "2023-10-12" @default.
• W3045265280 title "miRNA-21–3p targeting of FGF2 suppresses autophagy of bovine ovarian granulosa cells through AKT/mTOR pathway" @default.
• W3045265280 cites W1709510321 @default.
• W3045265280 cites W1822594881 @default.
• W3045265280 cites W1969943708 @default.
• W3045265280 cites W1974231851 @default.
• W3045265280 cites W1985725772 @default.
• W3045265280 cites W1985851879 @default.
• W3045265280 cites W1994450509 @default.
• W3045265280 cites W1998055848 @default.
• W3045265280 cites W1999514481 @default.
• W3045265280 cites W2000250544 @default.
• W3045265280 cites W2012458212 @default.
• W3045265280 cites W2014442719 @default.
• W3045265280 cites W2021958215 @default.
• W3045265280 cites W2022333470 @default.
• W3045265280 cites W2025098484 @default.
• W3045265280 cites W2025334893 @default.
• W3045265280 cites W2026446685 @default.
• W3045265280 cites W2026481212 @default.
• W3045265280 cites W2048131740 @default.
• W3045265280 cites W2065899119 @default.
• W3045265280 cites W2068153705 @default.
• W3045265280 cites W2072926599 @default.
• W3045265280 cites W2073990533 @default.
• W3045265280 cites W2081207546 @default.
• W3045265280 cites W2096078288 @default.
• W3045265280 cites W2106465830 @default.
• W3045265280 cites W2121629705 @default.
• W3045265280 cites W2122892477 @default.
• W3045265280 cites W2125768461 @default.
• W3045265280 cites W2135758370 @default.
• W3045265280 cites W2135810600 @default.
• W3045265280 cites W2135901758 @default.
• W3045265280 cites W2148145541 @default.
• W3045265280 cites W2148321928 @default.
• W3045265280 cites W2153000015 @default.
• W3045265280 cites W2160530836 @default.
• W3045265280 cites W2178316435 @default.
• W3045265280 cites W2279085311 @default.
• W3045265280 cites W2403537081 @default.
• W3045265280 cites W2463111790 @default.
• W3045265280 cites W2474919240 @default.
• W3045265280 cites W2587414698 @default.
• W3045265280 cites W2624245495 @default.
• W3045265280 cites W2749693449 @default.
• W3045265280 cites W2752326209 @default.
• W3045265280 cites W2758286496 @default.
• W3045265280 cites W2758797028 @default.
• W3045265280 cites W2761399066 @default.
• W3045265280 cites W2765667244 @default.
• W3045265280 cites W2792601526 @default.
• W3045265280 cites W2793498776 @default.
• W3045265280 cites W2793966428 @default.
• W3045265280 cites W2866751656 @default.
• W3045265280 cites W2892581569 @default.
• W3045265280 cites W2912567453 @default.
• W3045265280 cites W2976529879 @default.
• W3045265280 doi "https://doi.org/10.1016/j.theriogenology.2020.06.021" @default.
• W3045265280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32818880" @default.
• W3045265280 hasPublicationYear "2020" @default.
• W3045265280 type Work @default.
• W3045265280 sameAs 3045265280 @default.
• W3045265280 citedByCount "19" @default.
• W3045265280 countsByYear W30452652802021 @default.
• W3045265280 countsByYear W30452652802022 @default.
• W3045265280 countsByYear W30452652802023 @default.
• W3045265280 crossrefType "journal-article" @default.
• W3045265280 hasAuthorship W3045265280A5010153439 @default.
• W3045265280 hasAuthorship W3045265280A5016385766 @default.
• W3045265280 hasAuthorship W3045265280A5027183173 @default.
• W3045265280 hasAuthorship W3045265280A5030672669 @default.
• W3045265280 hasAuthorship W3045265280A5046881277 @default.
• W3045265280 hasAuthorship W3045265280A5065973605 @default.
• W3045265280 hasBestOaLocation W30452652801 @default.
• W3045265280 hasConcept C104317684 @default.
• W3045265280 hasConcept C145059251 @default.
• W3045265280 hasConcept C185592680 @default.
• W3045265280 hasConcept C190283241 @default.
• W3045265280 hasConcept C203522944 @default.
• W3045265280 hasConcept C43060935 @default.
• W3045265280 hasConcept C502942594 @default.
• W3045265280 hasConcept C55493867 @default.
• W3045265280 hasConcept C62478195 @default.
• W3045265280 hasConcept C75217442 @default.
• W3045265280 hasConcept C86554907 @default.
• W3045265280 hasConcept C86803240 @default.
• W3045265280 hasConcept C95444343 @default.
• W3045265280 hasConceptScore W3045265280C104317684 @default.

• next