Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045274368> ?p ?o ?g. }
- W3045274368 abstract "Abstract Lyme disease, caused by Borrelia burgdorferi , is an inflammatory multistage infection, consisting of localized, disseminated, and persistent disease stages, impacting several organ systems through poorly defined gene regulation mechanisms. The purpose of this study is to further characterize the spatiotemporal transcriptional regulation of B. burgdorferi during mammalian infection of borrelial oxidative stress regulator ( bosR ) and decorin binding protein ( dbpBA ) by utilizing bioluminescent B. burgdorferi reporter strains and in vivo imaging. Fluctuating borrelial load was also monitored and used for normalization to evaluate expression levels. bosR transcription is driven by two promoters, P bb0648 and P bosR , and we focused on the native promoter. bosR expression is low relative to the robustly expressed dbpBA throughout infection. In distal tissues, bosR was the highest in the heart during in the first week whereas dbpBA was readily detectable at all time points with each tissue displaying a distinct expression pattern. This data suggests bosR may have a role in heart colonization and the induction of dbpBA indicates a RpoS independent transcriptional regulation occurring in the mammalian cycle of pathogenesis. These finding demonstrate that B. burgdorferi engages unknown genetic mechanisms to uniquely respond to mammalian tissue environments and/or changing host response over time." @default.
- W3045274368 created "2020-07-29" @default.
- W3045274368 creator A5018788629 @default.
- W3045274368 creator A5055915670 @default.
- W3045274368 creator A5073031479 @default.
- W3045274368 date "2020-07-27" @default.
- W3045274368 modified "2023-09-24" @default.
- W3045274368 title "Borrelia burgdorferi spatiotemporal regulation of transcriptional regulator bosR and decorin binding protein during murine infection" @default.
- W3045274368 cites W1544976575 @default.
- W3045274368 cites W1557420229 @default.
- W3045274368 cites W1559018846 @default.
- W3045274368 cites W165005685 @default.
- W3045274368 cites W1755477882 @default.
- W3045274368 cites W1780111211 @default.
- W3045274368 cites W1875699510 @default.
- W3045274368 cites W1894787627 @default.
- W3045274368 cites W1908771231 @default.
- W3045274368 cites W1937263263 @default.
- W3045274368 cites W1946717434 @default.
- W3045274368 cites W1949520065 @default.
- W3045274368 cites W1977904572 @default.
- W3045274368 cites W1986984168 @default.
- W3045274368 cites W2013636685 @default.
- W3045274368 cites W2017047316 @default.
- W3045274368 cites W2035273924 @default.
- W3045274368 cites W2037758741 @default.
- W3045274368 cites W2042976887 @default.
- W3045274368 cites W2043454090 @default.
- W3045274368 cites W2049296526 @default.
- W3045274368 cites W2083663976 @default.
- W3045274368 cites W2093538084 @default.
- W3045274368 cites W2096065240 @default.
- W3045274368 cites W2096537028 @default.
- W3045274368 cites W2098764559 @default.
- W3045274368 cites W2099017965 @default.
- W3045274368 cites W2103025674 @default.
- W3045274368 cites W2105109145 @default.
- W3045274368 cites W2106061533 @default.
- W3045274368 cites W2106973436 @default.
- W3045274368 cites W2110368878 @default.
- W3045274368 cites W2110408657 @default.
- W3045274368 cites W2110842322 @default.
- W3045274368 cites W2112984193 @default.
- W3045274368 cites W2117557725 @default.
- W3045274368 cites W2120652759 @default.
- W3045274368 cites W2121386707 @default.
- W3045274368 cites W2121426156 @default.
- W3045274368 cites W2121555787 @default.
- W3045274368 cites W2124242639 @default.
- W3045274368 cites W2124475162 @default.
- W3045274368 cites W2128325038 @default.
- W3045274368 cites W2135278450 @default.
- W3045274368 cites W2135605184 @default.
- W3045274368 cites W2136252131 @default.
- W3045274368 cites W2139262548 @default.
- W3045274368 cites W2139636209 @default.
- W3045274368 cites W2140704881 @default.
- W3045274368 cites W2141059784 @default.
- W3045274368 cites W2142117803 @default.
- W3045274368 cites W2145466345 @default.
- W3045274368 cites W2145741346 @default.
- W3045274368 cites W2146745552 @default.
- W3045274368 cites W2150770083 @default.
- W3045274368 cites W2156198285 @default.
- W3045274368 cites W2157620368 @default.
- W3045274368 cites W2159988642 @default.
- W3045274368 cites W2162083336 @default.
- W3045274368 cites W2166361383 @default.
- W3045274368 cites W2166799325 @default.
- W3045274368 cites W2167128690 @default.
- W3045274368 cites W2167682215 @default.
- W3045274368 cites W2169468479 @default.
- W3045274368 cites W2346625597 @default.
- W3045274368 cites W2473311658 @default.
- W3045274368 cites W2514490234 @default.
- W3045274368 cites W2518630972 @default.
- W3045274368 cites W2622733194 @default.
- W3045274368 cites W2759296576 @default.
- W3045274368 cites W2809603719 @default.
- W3045274368 cites W2810877445 @default.
- W3045274368 cites W2939571318 @default.
- W3045274368 cites W4211094317 @default.
- W3045274368 cites W4211152344 @default.
- W3045274368 doi "https://doi.org/10.1038/s41598-020-69212-7" @default.
- W3045274368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7385660" @default.
- W3045274368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32719448" @default.
- W3045274368 hasPublicationYear "2020" @default.
- W3045274368 type Work @default.
- W3045274368 sameAs 3045274368 @default.
- W3045274368 citedByCount "6" @default.
- W3045274368 countsByYear W30452743682021 @default.
- W3045274368 countsByYear W30452743682022 @default.
- W3045274368 crossrefType "journal-article" @default.
- W3045274368 hasAuthorship W3045274368A5018788629 @default.
- W3045274368 hasAuthorship W3045274368A5055915670 @default.
- W3045274368 hasAuthorship W3045274368A5073031479 @default.
- W3045274368 hasBestOaLocation W30452743682 @default.
- W3045274368 hasConcept C101762097 @default.
- W3045274368 hasConcept C104317684 @default.
- W3045274368 hasConcept C138885662 @default.