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- W3045306672 abstract "BACKGROUND:Adrenal glucocorticoid cortisol maintains the cardiovascular function, decreases the catabolism and stabilizes the alveolar capillary membrane during inflammatory stress period. AIM OF THE STUDY: To determine the prevalence of adrenal insufficiency by measuring serum cortisol level in children with catecholamine dependent septic shock. METHOD: 49 children admitted with catecholamine dependant septic shock satisfying inclusion criteria recruited in to the study. Random serum cortisol was measured and correlated with various prognostic parameters like duration of inotropic and ventilator support, PICU and hospital stay and mortality. RESULT: The prevalence of adrenal insufficiency (< 18μgm/dl) was 41%. Duration of inotropic support (Median of 3 vs 2 days; P= 0.04), ventilator days (Median of 2.5 vs 1 day; P = 0.001) and proportionately the PICU stays (Median of 5 vs 4 days; P = 0.03) were significantly prolonged in the children with low cortisol when compared to children with normal cortisol level. Whereas the total duration of hospital stay (Median days of 10 vs 7; P=0.07) and the mortality (7 children in each group 35% vs 24%; p=0.304) were comparable between the two groups. CONCLUSION: we concluded that the low serum cortisol was a common finding among children suffering catecholamine dependent septic shock and it was positively correlated with prolonged hemodynamic, respiratory support and ICU care. We require further study to delineate the incidence of absolute and relative adrenal insufficiency by doing a stimulation test and also require controlled randomized trials to analyse the benefits of steroid supplementation on morbidity and mortality of these children." @default.
- W3045306672 created "2020-07-29" @default.
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- W3045306672 date "2017-04-01" @default.
- W3045306672 modified "2023-09-27" @default.
- W3045306672 title "Serum Cortisol level in children with catecholamine dependent shock: A Prospective Observational study" @default.
- W3045306672 hasPublicationYear "2017" @default.
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