FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045366469> ?p ?o ?g. }

• W3045366469 abstract "Liquid biopsy using circulating microvesicles and exosomes is emerging as a new diagnostic tool that could improve hepatocellular carcinoma (HCC) early diagnosis and screening protocols. Our study aimed to investigate the utility of plasma exosomal miR-21-5p and miR-92-3p for HCC diagnosis during screening protocols.The study group included 106 subjects: 48 patients diagnosed with HCC during screening, who underwent a potentially curative treatment (surgical resection or liver transplantation), 38 patients with liver cirrhosis (LC) on the waiting list for liver transplantation, and 20 healthy volunteers. The exosomes were isolated by precipitation with a reagent based on polyethylene glycol and were characterized based on morphological aspects (i.e., diameter); molecular weight; CD63, CD9, and CD81 protein markers; and exosomal miR-21-5p and miR-92a-3p expression levels.We first demonstrate that the exosome population isolated with the commercially available Total Exosome Isolation kit respects the same size ranging, morphological, and protein expression aspects compared to the traditional ultracentrifugation technique. The analysis of the expression profile indicates that miR-21-5p was upregulated (p = 0.017), and miR-92a-3p was downregulated (p = 0.0005) in plasma-derived exosomes from HCC subjects, independently from the patient's characteristics. AUROC for HCC diagnosis based on AFP (alpha-fetoprotein) was 0.72. By integrating AFP and the relative expression of exosomal miR-21-5p and miR-92a-3p in a logistic regression equation for HCC diagnosis, the combined AUROC of the new exosomal miR HCC score was 0.85-significantly better than serum AFP alone (p = 0.0007).Together with serum AFP, plasma exosomal miR-21-5p and miR-92a-3p could be used as potential biomarkers for HCC diagnosis in patients with LC subjected to screening and surveillance." @default.
• W3045366469 created "2020-07-29" @default.
• W3045366469 creator A5004233110 @default.
• W3045366469 creator A5011334151 @default.
• W3045366469 creator A5023690844 @default.
• W3045366469 creator A5026937938 @default.
• W3045366469 creator A5034894422 @default.
• W3045366469 creator A5038707478 @default.
• W3045366469 creator A5042584699 @default.
• W3045366469 creator A5052246635 @default.
• W3045366469 creator A5059909312 @default.
• W3045366469 creator A5062174706 @default.
• W3045366469 creator A5072171642 @default.
• W3045366469 creator A5007705325 @default.
• W3045366469 creator A5023294542 @default.
• W3045366469 date "2020-07-23" @default.
• W3045366469 modified "2023-10-18" @default.
• W3045366469 title "Plasma Small Extracellular Vesicles Derived miR-21-5p and miR-92a-3p as Potential Biomarkers for Hepatocellular Carcinoma Screening" @default.
• W3045366469 cites W1489663513 @default.
• W3045366469 cites W1500925570 @default.
• W3045366469 cites W1583187865 @default.
• W3045366469 cites W1631051547 @default.
• W3045366469 cites W1877686344 @default.
• W3045366469 cites W1904256709 @default.
• W3045366469 cites W1971385615 @default.
• W3045366469 cites W1989941644 @default.
• W3045366469 cites W1991118625 @default.
• W3045366469 cites W1991944677 @default.
• W3045366469 cites W2000093333 @default.
• W3045366469 cites W2015419250 @default.
• W3045366469 cites W2025389008 @default.
• W3045366469 cites W2026703961 @default.
• W3045366469 cites W2063151064 @default.
• W3045366469 cites W2067068977 @default.
• W3045366469 cites W2107008239 @default.
• W3045366469 cites W2118231569 @default.
• W3045366469 cites W2123730033 @default.
• W3045366469 cites W2131081587 @default.
• W3045366469 cites W2135686606 @default.
• W3045366469 cites W2148630375 @default.
• W3045366469 cites W2159401023 @default.
• W3045366469 cites W2169751384 @default.
• W3045366469 cites W2170852633 @default.
• W3045366469 cites W2190836196 @default.
• W3045366469 cites W2238063610 @default.
• W3045366469 cites W2277004004 @default.
• W3045366469 cites W2338671470 @default.
• W3045366469 cites W2344857743 @default.
• W3045366469 cites W2409427944 @default.
• W3045366469 cites W2509033031 @default.
• W3045366469 cites W2569705407 @default.
• W3045366469 cites W2575253560 @default.
• W3045366469 cites W2582878252 @default.
• W3045366469 cites W2586743233 @default.
• W3045366469 cites W2621794285 @default.
• W3045366469 cites W2736407666 @default.
• W3045366469 cites W2761031851 @default.
• W3045366469 cites W2786099441 @default.
• W3045366469 cites W2790169109 @default.
• W3045366469 cites W2883813741 @default.
• W3045366469 cites W2889850548 @default.
• W3045366469 cites W2891386378 @default.
• W3045366469 cites W2907518099 @default.
• W3045366469 cites W2954329183 @default.
• W3045366469 cites W2977743050 @default.
• W3045366469 cites W2981871574 @default.
• W3045366469 cites W2982103369 @default.
• W3045366469 cites W2983020673 @default.
• W3045366469 cites W2986122002 @default.
• W3045366469 cites W791787195 @default.
• W3045366469 doi "https://doi.org/10.3389/fgene.2020.00712" @default.
• W3045366469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7391066" @default.
• W3045366469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32793278" @default.
• W3045366469 hasPublicationYear "2020" @default.
• W3045366469 type Work @default.
• W3045366469 sameAs 3045366469 @default.
• W3045366469 citedByCount "33" @default.
• W3045366469 countsByYear W30453664692020 @default.
• W3045366469 countsByYear W30453664692021 @default.
• W3045366469 countsByYear W30453664692022 @default.
• W3045366469 countsByYear W30453664692023 @default.
• W3045366469 crossrefType "journal-article" @default.
• W3045366469 hasAuthorship W3045366469A5004233110 @default.
• W3045366469 hasAuthorship W3045366469A5007705325 @default.
• W3045366469 hasAuthorship W3045366469A5011334151 @default.
• W3045366469 hasAuthorship W3045366469A5023294542 @default.
• W3045366469 hasAuthorship W3045366469A5023690844 @default.
• W3045366469 hasAuthorship W3045366469A5026937938 @default.
• W3045366469 hasAuthorship W3045366469A5034894422 @default.
• W3045366469 hasAuthorship W3045366469A5038707478 @default.
• W3045366469 hasAuthorship W3045366469A5042584699 @default.
• W3045366469 hasAuthorship W3045366469A5052246635 @default.
• W3045366469 hasAuthorship W3045366469A5059909312 @default.
• W3045366469 hasAuthorship W3045366469A5062174706 @default.
• W3045366469 hasAuthorship W3045366469A5072171642 @default.
• W3045366469 hasBestOaLocation W30453664691 @default.
• W3045366469 hasConcept C104317684 @default.
• W3045366469 hasConcept C121608353 @default.
• W3045366469 hasConcept C126322002 @default.
• W3045366469 hasConcept C142724271 @default.

• next