Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045413141> ?p ?o ?g. }
- W3045413141 abstract "Human intestinal organoids (HIOs) generated from pluripotent stem cells provide extraordinary opportunities to explore development and disease. Here, we generate a single-cell transcriptome reference atlas from HIOs and from multiple developing human organs to quantify the specificity of HIO cell fate acquisition, and to explore alternative fates. We identify epithelium-mesenchyme interactions, transcriptional regulators involved in cell fate specification, and stem cell maturation features in the primary tissue that are recapitulated in HIOs. We use an HIO time course to reconstruct the molecular dynamics of intestinal stem cell emergence, as well as the specification of multiple mesenchyme subtypes. We find that the intestinal master regulator CDX2 correlates with distinct phases of epithelial and mesenchymal development, and CDX2 deletion perturbs the differentiation of both intestinal epithelium and mesenchyme. Collectively our data provides a comprehensive and quantitative assessment of HIO development, and illuminates the molecular machinery underlying endodermal and mesodermal cell fate specification." @default.
- W3045413141 created "2020-07-29" @default.
- W3045413141 creator A5009177654 @default.
- W3045413141 creator A5027963713 @default.
- W3045413141 creator A5035181689 @default.
- W3045413141 creator A5036862716 @default.
- W3045413141 creator A5038194886 @default.
- W3045413141 creator A5040983764 @default.
- W3045413141 creator A5060150538 @default.
- W3045413141 creator A5061025737 @default.
- W3045413141 creator A5068100543 @default.
- W3045413141 creator A5070799693 @default.
- W3045413141 creator A5071389567 @default.
- W3045413141 creator A5077361437 @default.
- W3045413141 creator A5078845326 @default.
- W3045413141 creator A5079025262 @default.
- W3045413141 date "2020-07-25" @default.
- W3045413141 modified "2023-10-14" @default.
- W3045413141 title "An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine" @default.
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