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• W3045419340 abstract "Background Combined hepatocellular-cholangiocarcinoma (CHC) is a rare subtype of primary hepatic malignancies, with variably reported incidence between 0.4%–14.2% of primary liver cancer cases. This study aimed to systematically review the epidemiological, clinicopathological, diagnostic and therapeutic data for this rare entity. Data sources We reviewed the literature of diagnostic approach of CHC with special reference to its clinical, molecular and histopathological characteristics. Additional analysis of the recent literature in order to evaluate the results of surgical and systemic treatment of this entity has been accomplished. Results The median age at CHC's diagnosis appears to be between 50 and 75 years. Evaluation of tumor markers [alpha fetoprotein (AFP), carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)] along with imaging patterns provides better opportunities for CHC's preoperative diagnosis. Reported clinicopathologic prognostic parameters possibly correlated with increased tumor recurrence and grimmer survival odds include advanced age, tumor size, nodal and distal metastases, vascular and regional organ invasion, multifocality, decreased capsule formation, stem-cell features verification and increased GGT as well as CA19–9 and CEA levels. In case of inoperable or recurrent disease, combinations of cholangiocarcinoma-directed systemic agents display superior results over sorafenib. Liver-directed methods, such as transarterial chemoembolization (TACE), percutaneous ethanol injection (PEI), hepatic arterial infusion chemotherapy (HAIC), radioembolization and ablative therapies, demonstrate inferior efficacy than in cases of hepatocellular carcinoma (HCC) due to CHC's common hypovascularity. Conclusions CHC demonstrates an overlapping clinical and biological pattern between its malignant ingredients. Natural history of the disease seems to be determined by the predominant tumor element. Gold standard for diagnosis is histology of surgical specimens. Regarding therapeutic interventions, major hepatectomy is acknowledged as the cornerstone of treatment whereas minor hepatectomy and liver transplantation may be applied in patients with advanced cirrhosis. Despite all therapeutic attempts, prognosis of CHC remains dismal." @default.
• W3045419340 created "2020-07-29" @default.
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• W3045419340 date "2020-12-01" @default.
• W3045419340 modified "2023-09-27" @default.
• W3045419340 title "Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management" @default.
• W3045419340 cites W1544697940 @default.
• W3045419340 cites W1805647656 @default.
• W3045419340 cites W1895232916 @default.
• W3045419340 cites W1957320625 @default.
• W3045419340 cites W1974474071 @default.
• W3045419340 cites W1987048252 @default.
• W3045419340 cites W1991338141 @default.
• W3045419340 cites W2001647118 @default.
• W3045419340 cites W2006657514 @default.
• W3045419340 cites W2013109354 @default.
• W3045419340 cites W2023931972 @default.
• W3045419340 cites W2037680028 @default.
• W3045419340 cites W2039159845 @default.
• W3045419340 cites W2056495072 @default.
• W3045419340 cites W2060127712 @default.
• W3045419340 cites W2069486732 @default.
• W3045419340 cites W2076482153 @default.
• W3045419340 cites W2082689697 @default.
• W3045419340 cites W2092596093 @default.
• W3045419340 cites W2095435148 @default.
• W3045419340 cites W2107677923 @default.
• W3045419340 cites W2109802711 @default.
• W3045419340 cites W2115781548 @default.
• W3045419340 cites W2116598408 @default.
• W3045419340 cites W2121456131 @default.
• W3045419340 cites W2130396153 @default.
• W3045419340 cites W2138436686 @default.
• W3045419340 cites W2140359458 @default.
• W3045419340 cites W2144597430 @default.
• W3045419340 cites W2146352307 @default.
• W3045419340 cites W2148955494 @default.
• W3045419340 cites W2269960584 @default.
• W3045419340 cites W2277256451 @default.
• W3045419340 cites W2297147549 @default.
• W3045419340 cites W2386199682 @default.
• W3045419340 cites W2508375240 @default.
• W3045419340 cites W2559331417 @default.
• W3045419340 cites W2581437091 @default.
• W3045419340 cites W2586861912 @default.
• W3045419340 cites W2592872345 @default.
• W3045419340 cites W2605529724 @default.
• W3045419340 cites W2620643768 @default.
• W3045419340 cites W2751681739 @default.
• W3045419340 cites W2767256408 @default.
• W3045419340 cites W2771057425 @default.
• W3045419340 cites W2789901176 @default.
• W3045419340 cites W2791610821 @default.
• W3045419340 cites W2791662927 @default.
• W3045419340 cites W2791930738 @default.
• W3045419340 cites W2792288332 @default.
• W3045419340 cites W2800198494 @default.
• W3045419340 cites W2806425777 @default.
• W3045419340 cites W2806992588 @default.
• W3045419340 cites W2807322325 @default.
• W3045419340 cites W2889225530 @default.
• W3045419340 cites W2889646458 @default.
• W3045419340 cites W2897966671 @default.
• W3045419340 cites W2899329973 @default.
• W3045419340 cites W2900431092 @default.
• W3045419340 cites W2901074067 @default.
• W3045419340 cites W2901407291 @default.
• W3045419340 cites W2905138014 @default.
• W3045419340 cites W2907759260 @default.
• W3045419340 cites W2911254261 @default.
• W3045419340 cites W2915887504 @default.
• W3045419340 cites W2921433459 @default.
• W3045419340 cites W2924592880 @default.
• W3045419340 cites W2925545897 @default.
• W3045419340 cites W2944730589 @default.
• W3045419340 cites W2952464140 @default.
• W3045419340 cites W2963938697 @default.
• W3045419340 cites W2969542839 @default.
• W3045419340 cites W2975897802 @default.
• W3045419340 cites W2999298357 @default.
• W3045419340 cites W3008477589 @default.
• W3045419340 doi "https://doi.org/10.1016/j.hbpd.2020.07.004" @default.
• W3045419340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32753331" @default.
• W3045419340 hasPublicationYear "2020" @default.
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