FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045457999> ?p ?o ?g. }

• W3045457999 endingPage "15" @default.
• W3045457999 startingPage "1" @default.
• W3045457999 abstract "Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to the development and progression of pulmonary vascular remodeling and obliterative vascular lesions in patients with pulmonary arterial hypertension. In this study, we examined the expression of platelet-derived growth factor receptor isoforms in pulmonary arterial smooth muscle and pulmonary arterial endothelial cells and investigated whether platelet-derived growth factor secreted from pulmonary arterial smooth muscle cell or pulmonary arterial endothelial cell promotes pulmonary arterial smooth muscle cell proliferation. Our results showed that the protein expression of platelet-derived growth factor receptor α and platelet-derived growth factor receptor β in pulmonary arterial smooth muscle cell was upregulated in patients with idiopathic pulmonary arterial hypertension compared to normal subjects. Platelet-derived growth factor activated platelet-derived growth factor receptor α and platelet-derived growth factor receptor β in pulmonary arterial smooth muscle cell, as determined by phosphorylation of platelet-derived growth factor receptor α and platelet-derived growth factor receptor β. The platelet-derived growth factor-mediated activation of platelet-derived growth factor receptor α/platelet-derived growth factor receptor β was enhanced in idiopathic pulmonary arterial hypertension-pulmonary arterial smooth muscle cell compared to normal cells. Expression level of platelet-derived growth factor-AA and platelet-derived growth factor-BB was greater in the conditioned media collected from idiopathic pulmonary arterial hypertension-pulmonary arterial endothelial cell than from normal pulmonary arterial endothelial cell. Furthermore, incubation of idiopathic pulmonary arterial hypertension-pulmonary arterial smooth muscle cell with conditioned culture media from normal pulmonary arterial endothelial cell induced more platelet-derived growth factor receptor α activation than in normal pulmonary arterial smooth muscle cell. Accordingly, the conditioned media from idiopathic pulmonary arterial hypertension-pulmonary arterial endothelial cell resulted in more pulmonary arterial smooth muscle cell proliferation than the media from normal pulmonary arterial endothelial cell. These data indicate that (a) the expression and activity of platelet-derived growth factor receptor are increased in idiopathic pulmonary arterial hypertension-pulmonary arterial smooth muscle cell compared to normal pulmonary arterial smooth muscle cell, and (b) pulmonary arterial endothelial cell from idiopathic pulmonary arterial hypertension patients secretes higher level of platelet-derived growth factor than pulmonary arterial endothelial cell from normal subjects. The enhanced secretion (and production) of platelet-derived growth factor from idiopathic pulmonary arterial hypertension-pulmonary arterial endothelial cell and upregulated platelet-derived growth factor receptor expression (and function) in idiopathic pulmonary arterial hypertension-pulmonary arterial smooth muscle cell may contribute to enhancing platelet-derived growth factor/platelet-derived growth factor receptor-associated pulmonary vascular remodeling in pulmonary arterial hypertension." @default.
• W3045457999 created "2020-07-29" @default.
• W3045457999 creator A5001162420 @default.
• W3045457999 creator A5001408192 @default.
• W3045457999 creator A5008213446 @default.
• W3045457999 creator A5024165645 @default.
• W3045457999 creator A5029552856 @default.
• W3045457999 creator A5030575700 @default.
• W3045457999 creator A5030915368 @default.
• W3045457999 creator A5032764121 @default.
• W3045457999 creator A5039381731 @default.
• W3045457999 creator A5052491243 @default.
• W3045457999 creator A5056829553 @default.
• W3045457999 creator A5061374931 @default.
• W3045457999 creator A5064026168 @default.
• W3045457999 creator A5064441182 @default.
• W3045457999 creator A5069603319 @default.
• W3045457999 creator A5070187864 @default.
• W3045457999 creator A5074021206 @default.
• W3045457999 creator A5076637933 @default.
• W3045457999 creator A5076803549 @default.
• W3045457999 creator A5077651225 @default.
• W3045457999 creator A5078896449 @default.
• W3045457999 date "2020-07-01" @default.
• W3045457999 modified "2023-10-17" @default.
• W3045457999 title "Endothelial platelet‐derived growth factor‐mediated activation of smooth muscle platelet‐derived growth factor receptors in pulmonary arterial hypertension" @default.
• W3045457999 cites W1606906610 @default.
• W3045457999 cites W1929000169 @default.
• W3045457999 cites W1979129486 @default.
• W3045457999 cites W1979770196 @default.
• W3045457999 cites W1992905803 @default.
• W3045457999 cites W1996524391 @default.
• W3045457999 cites W1998990808 @default.
• W3045457999 cites W1999887461 @default.
• W3045457999 cites W2006343358 @default.
• W3045457999 cites W2006541679 @default.
• W3045457999 cites W2013462865 @default.
• W3045457999 cites W2016086822 @default.
• W3045457999 cites W2016671121 @default.
• W3045457999 cites W2024338340 @default.
• W3045457999 cites W2031414702 @default.
• W3045457999 cites W2048273899 @default.
• W3045457999 cites W2050487884 @default.
• W3045457999 cites W2062002285 @default.
• W3045457999 cites W2065260396 @default.
• W3045457999 cites W2070069927 @default.
• W3045457999 cites W2076914219 @default.
• W3045457999 cites W2102256639 @default.
• W3045457999 cites W2109730452 @default.
• W3045457999 cites W2115541452 @default.
• W3045457999 cites W2116057774 @default.
• W3045457999 cites W2120189110 @default.
• W3045457999 cites W2123340693 @default.
• W3045457999 cites W2125393205 @default.
• W3045457999 cites W2128450740 @default.
• W3045457999 cites W2132324778 @default.
• W3045457999 cites W2145016693 @default.
• W3045457999 cites W2147944062 @default.
• W3045457999 cites W2150029109 @default.
• W3045457999 cites W2156673166 @default.
• W3045457999 cites W2157869421 @default.
• W3045457999 cites W2158696025 @default.
• W3045457999 cites W2160692275 @default.
• W3045457999 cites W2163380244 @default.
• W3045457999 cites W2169220357 @default.
• W3045457999 cites W2170779936 @default.
• W3045457999 cites W2180845934 @default.
• W3045457999 cites W2268531581 @default.
• W3045457999 cites W2337592013 @default.
• W3045457999 cites W2564544710 @default.
• W3045457999 cites W2565424224 @default.
• W3045457999 cites W2606009302 @default.
• W3045457999 cites W2737004789 @default.
• W3045457999 cites W2783225214 @default.
• W3045457999 cites W2785187934 @default.
• W3045457999 cites W2791062907 @default.
• W3045457999 cites W2792856682 @default.
• W3045457999 cites W2800122917 @default.
• W3045457999 cites W2891194116 @default.
• W3045457999 cites W2891636773 @default.
• W3045457999 cites W2901159138 @default.
• W3045457999 cites W2909232353 @default.
• W3045457999 cites W2922006472 @default.
• W3045457999 cites W2924451433 @default.
• W3045457999 cites W2953933972 @default.
• W3045457999 cites W2988134078 @default.
• W3045457999 cites W2996707518 @default.
• W3045457999 cites W3003003290 @default.
• W3045457999 cites W3004418786 @default.
• W3045457999 cites W3004916349 @default.
• W3045457999 cites W3006378540 @default.
• W3045457999 cites W3102723472 @default.
• W3045457999 cites W97315469 @default.
• W3045457999 doi "https://doi.org/10.1177/2045894020948470" @default.
• W3045457999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7707860" @default.
• W3045457999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33294172" @default.
• W3045457999 hasPublicationYear "2020" @default.
• W3045457999 type Work @default.

• next