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• W3045490785 abstract "Multi-functional design of ligands emerged as a new drug design paradigm of Alzheimer’s disease (AD). Given the complexity of AD, the molecules showing dual inhibition of monoamine oxidase (MAO) and acetylcholinesterase (AChE) with neuroprotective properties could prevent the progressive neural degeneration effectively. Numerous studies documented that chalcone is a privileged structural framework for the inhibition of both MAO and AChE. The recent studies suggested that the development of chalcone candidates endowed with pharmacophores of FDA approved drugs may become an active molecules in the field of current AD research. The current perspective described the recent updates of chalcone moiety linked with the pharmacophores of flurbiprofen and rivastigmine hybrids as selective ChE/MAO-B inhibitors for the prophylactic agents for AD." @default.
• W3045490785 created "2020-08-03" @default.
• W3045490785 creator A5023941392 @default.
• W3045490785 date "2020-12-22" @default.
• W3045490785 modified "2023-09-25" @default.
• W3045490785 title "Privileged Pharmacophore of FDA Approved Drugs in Combination with Chalcone Framework: A New Hope for Alzheimer’s Treatment" @default.
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• W3045490785 doi "https://doi.org/10.2174/1386207323999200728122627" @default.
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