FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045496771> ?p ?o ?g. }

• W3045496771 abstract "Abstract Background There is a plethora of methods for genome-wide association studies. However, only a few of them may be classified as multi-trait and multi-locus, i.e. consider the influence of multiple genetic variants to several correlated phenotypes. Results We propose a multi-trait multi-locus model which employs structural equation modeling (SEM) to describe complex associations between SNPs and traits - m ulti- t rait m ulti- l ocus SEM (mtmlSEM). The structure of our model makes it possible to discriminate pleiotropic and single-trait SNPs of direct and indirect effect. We also propose an automatic procedure to construct the model using factor analysis and the maximum likelihood method. For estimating a large number of parameters in the model, we performed Bayesian inference and implemented Gibbs sampling. An important feature of the model is that it correctly copes with non-normally distributed variables, such as some traits and variants. Conclusions We applied the model to Vavilov’s collection of 404 chickpea ( Cicer arietinum L.) accessions with 20-fold cross-validation. We analyzed 16 phenotypic traits which we organized into five groups and found around 230 SNPs associated with traits, 60 of which were of pleiotropic effect. The model demonstrated high accuracy in predicting trait values." @default.
• W3045496771 created "2020-08-03" @default.
• W3045496771 creator A5011471917 @default.
• W3045496771 creator A5015017270 @default.
• W3045496771 creator A5026445054 @default.
• W3045496771 creator A5031500055 @default.
• W3045496771 creator A5067770825 @default.
• W3045496771 date "2020-07-01" @default.
• W3045496771 modified "2023-10-08" @default.
• W3045496771 title "Multi-trait multi-locus SEM model discriminates SNPs of different effects" @default.
• W3045496771 cites W1598494444 @default.
• W3045496771 cites W167374121 @default.
• W3045496771 cites W1784626615 @default.
• W3045496771 cites W1976587387 @default.
• W3045496771 cites W1980168725 @default.
• W3045496771 cites W2000190151 @default.
• W3045496771 cites W2006868411 @default.
• W3045496771 cites W2008239012 @default.
• W3045496771 cites W2009889728 @default.
• W3045496771 cites W2024999855 @default.
• W3045496771 cites W2025311389 @default.
• W3045496771 cites W2050029156 @default.
• W3045496771 cites W2055234679 @default.
• W3045496771 cites W2064350862 @default.
• W3045496771 cites W2064943828 @default.
• W3045496771 cites W2082246284 @default.
• W3045496771 cites W2088477804 @default.
• W3045496771 cites W2108069662 @default.
• W3045496771 cites W2122189635 @default.
• W3045496771 cites W2129813466 @default.
• W3045496771 cites W2146374090 @default.
• W3045496771 cites W2155992983 @default.
• W3045496771 cites W2157291679 @default.
• W3045496771 cites W2158277627 @default.
• W3045496771 cites W2166426981 @default.
• W3045496771 cites W2411251289 @default.
• W3045496771 cites W2585681007 @default.
• W3045496771 cites W2595699020 @default.
• W3045496771 cites W2646189686 @default.
• W3045496771 cites W2760544538 @default.
• W3045496771 cites W2766556645 @default.
• W3045496771 cites W2780560743 @default.
• W3045496771 cites W2803962067 @default.
• W3045496771 cites W2804161943 @default.
• W3045496771 cites W2810616698 @default.
• W3045496771 cites W2885647429 @default.
• W3045496771 cites W2896921363 @default.
• W3045496771 cites W2944230189 @default.
• W3045496771 cites W2973627903 @default.
• W3045496771 cites W3038052992 @default.
• W3045496771 cites W4298091299 @default.
• W3045496771 doi "https://doi.org/10.1186/s12864-020-06833-2" @default.
• W3045496771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7385891" @default.
• W3045496771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32723302" @default.
• W3045496771 hasPublicationYear "2020" @default.
• W3045496771 type Work @default.
• W3045496771 sameAs 3045496771 @default.
• W3045496771 citedByCount "5" @default.
• W3045496771 countsByYear W30454967712022 @default.
• W3045496771 countsByYear W30454967712023 @default.
• W3045496771 crossrefType "journal-article" @default.
• W3045496771 hasAuthorship W3045496771A5011471917 @default.
• W3045496771 hasAuthorship W3045496771A5015017270 @default.
• W3045496771 hasAuthorship W3045496771A5026445054 @default.
• W3045496771 hasAuthorship W3045496771A5031500055 @default.
• W3045496771 hasAuthorship W3045496771A5067770825 @default.
• W3045496771 hasBestOaLocation W30454967711 @default.
• W3045496771 hasConcept C104317684 @default.
• W3045496771 hasConcept C105795698 @default.
• W3045496771 hasConcept C106208931 @default.
• W3045496771 hasConcept C106934330 @default.
• W3045496771 hasConcept C107673813 @default.
• W3045496771 hasConcept C135763542 @default.
• W3045496771 hasConcept C153209595 @default.
• W3045496771 hasConcept C154945302 @default.
• W3045496771 hasConcept C158424031 @default.
• W3045496771 hasConcept C160234255 @default.
• W3045496771 hasConcept C199360897 @default.
• W3045496771 hasConcept C2776214188 @default.
• W3045496771 hasConcept C33923547 @default.
• W3045496771 hasConcept C41008148 @default.
• W3045496771 hasConcept C54355233 @default.
• W3045496771 hasConcept C70721500 @default.
• W3045496771 hasConcept C78458016 @default.
• W3045496771 hasConcept C81941488 @default.
• W3045496771 hasConcept C84597430 @default.
• W3045496771 hasConcept C86803240 @default.
• W3045496771 hasConcept C9287583 @default.
• W3045496771 hasConceptScore W3045496771C104317684 @default.
• W3045496771 hasConceptScore W3045496771C105795698 @default.
• W3045496771 hasConceptScore W3045496771C106208931 @default.
• W3045496771 hasConceptScore W3045496771C106934330 @default.
• W3045496771 hasConceptScore W3045496771C107673813 @default.
• W3045496771 hasConceptScore W3045496771C135763542 @default.
• W3045496771 hasConceptScore W3045496771C153209595 @default.
• W3045496771 hasConceptScore W3045496771C154945302 @default.
• W3045496771 hasConceptScore W3045496771C158424031 @default.
• W3045496771 hasConceptScore W3045496771C160234255 @default.
• W3045496771 hasConceptScore W3045496771C199360897 @default.
• W3045496771 hasConceptScore W3045496771C2776214188 @default.

• next