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- W3045504827 endingPage "721" @default.
- W3045504827 startingPage "709" @default.
- W3045504827 abstract "Abstract Rearrangements of the MLLT10 gene occur in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), most commonly T‐lineage ALL (T‐ALL), in patients of all ages. MLLT10 rearranged ( MLLT10 r) acute leukemia presents a complex diagnostic and therapeutic challenge due to frequent presentation of immature or mixed phenotype, and a lack of consensus regarding optimal therapy. Cases of MLLT10 r AML or T‐ALL bearing immature phenotype are at high risk of poor outcome, but the underlying molecular mechanisms and sensitivity to targeted therapies remain poorly characterized. This review addresses the incidence and prognostic significance of MLLT10 r in acute leukemia, and how the aberrant gene expression profile of this disease can inform potential targeted therapeutic strategies. Understanding the underlying genomics of MLLT10 r acute leukemia, both clinically and molecularly, will improve prognostic stratification and accelerate the development of targeted therapeutic strategies, to improve patient outcomes." @default.
- W3045504827 created "2020-08-03" @default.
- W3045504827 creator A5002537433 @default.
- W3045504827 creator A5023254607 @default.
- W3045504827 creator A5026996624 @default.
- W3045504827 creator A5042140091 @default.
- W3045504827 creator A5048203605 @default.
- W3045504827 date "2020-08-15" @default.
- W3045504827 modified "2023-10-16" @default.
- W3045504827 title "<scp> <i>MLLT10</i> </scp> rearranged acute leukemia: Incidence, prognosis, and possible therapeutic strategies" @default.
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