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- W3045519314 endingPage "2106" @default.
- W3045519314 startingPage "2106" @default.
- W3045519314 abstract "DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes. These include factors that have been associated with all the hallmarks of cancer, from genomic instability to increased proliferation and resistance, programmed cell death, or signaling pathways whose dysfunction is relevant to tumor onset and progression. In accordance with an involvement of DYRK kinases in the regulation of tumorigenic processes, an increasing number of research studies have been published in recent years showing either alterations of DYRK gene expression in tumor samples and/or providing evidence of DYRK-dependent mechanisms that contribute to tumor initiation and/or progression. In the present article, we will review the current understanding of the role of DYRK family members in cancer initiation and progression, providing an overview of the small molecules that act as DYRK inhibitors and discussing the clinical implications and therapeutic opportunities currently available." @default.
- W3045519314 created "2020-08-03" @default.
- W3045519314 creator A5016203820 @default.
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- W3045519314 creator A5066082571 @default.
- W3045519314 creator A5073262254 @default.
- W3045519314 creator A5076690926 @default.
- W3045519314 date "2020-07-29" @default.
- W3045519314 modified "2023-10-17" @default.
- W3045519314 title "The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities" @default.
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