FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045536489> ?p ?o ?g. }

• W3045536489 abstract "Abstract Objectives Maintenance treatment with macrolide antibiotics has shown to be effective in reducing exacerbations in COPD patients. A major concern with prolonged treatment with antibiotics is the development of bacterial resistance. In this study we determined the effect of azithromycin on the development and acquisition of resistance to macrolides in the nasopharyngeal flora in COPD patients. Methods This study was part of the COLUMBUS trial, a randomised, double-blind, placebo-controlled trial to measure the effect of maintenance treatment with azithromycin in 92 COPD patients on the exacerbation rates during a 12-month period. In order to determine resistance to macrolides, we used a targeted metagenomic approach to measure the presence and relative abundance of specific macrolide resistance genes ermB , ermF and mefA in throat samples collected at different time-points during this 12-month period. Results There was no increased risk for acquisition of macrolide resistance genes in the azithromycin group compared to the placebo group in COPD patients. However, loss of the macrolide resistance gene ermB was increased overtime in the placebo treated group compared to the azithromycin group ( n = 5 for the placebo group versus n = 0 for the azithromycin group at 12 months; p = 0.012). The change in relative abundance of the three macrolide-resistance genes showed that all but one ( ermF ) increased during treatment with azithromycin. Conclusions The acquisition rate of macrolide resistance genes in COPD patients treated with azithromycin maintenance therapy was limited, but the relative abundance of macrolide resistance genes increased significantly over time compared to placebo. This study was part of the COLUMBUS trial ( Clinicaltrials.gov , NCT00985244 )." @default.
• W3045536489 created "2020-08-03" @default.
• W3045536489 creator A5022343668 @default.
• W3045536489 creator A5030061739 @default.
• W3045536489 creator A5034952482 @default.
• W3045536489 creator A5040584914 @default.
• W3045536489 creator A5042914571 @default.
• W3045536489 creator A5053049764 @default.
• W3045536489 creator A5057731621 @default.
• W3045536489 creator A5069798085 @default.
• W3045536489 creator A5082595095 @default.
• W3045536489 creator A5091176390 @default.
• W3045536489 date "2020-07-28" @default.
• W3045536489 modified "2023-10-14" @default.
• W3045536489 title "Prevalence and abundance of selected genes conferring macrolide resistance genes in COPD patients during maintenance treatment with azithromycin" @default.
• W3045536489 cites W1968463338 @default.
• W3045536489 cites W1971501025 @default.
• W3045536489 cites W1973530626 @default.
• W3045536489 cites W1988907123 @default.
• W3045536489 cites W1998275177 @default.
• W3045536489 cites W2017342983 @default.
• W3045536489 cites W2041376642 @default.
• W3045536489 cites W2056289627 @default.
• W3045536489 cites W2073044205 @default.
• W3045536489 cites W2089312626 @default.
• W3045536489 cites W2096373158 @default.
• W3045536489 cites W2097618796 @default.
• W3045536489 cites W2100209873 @default.
• W3045536489 cites W2103508277 @default.
• W3045536489 cites W2105160780 @default.
• W3045536489 cites W2108244474 @default.
• W3045536489 cites W2108424624 @default.
• W3045536489 cites W2115164382 @default.
• W3045536489 cites W2115701239 @default.
• W3045536489 cites W2117837864 @default.
• W3045536489 cites W2124612605 @default.
• W3045536489 cites W2125420295 @default.
• W3045536489 cites W2130914578 @default.
• W3045536489 cites W2131237771 @default.
• W3045536489 cites W2133728497 @default.
• W3045536489 cites W2136960553 @default.
• W3045536489 cites W2137969357 @default.
• W3045536489 cites W2141317813 @default.
• W3045536489 cites W2163467593 @default.
• W3045536489 cites W2165928362 @default.
• W3045536489 cites W2498876603 @default.
• W3045536489 cites W2802675021 @default.
• W3045536489 cites W2897109701 @default.
• W3045536489 cites W48627372 @default.
• W3045536489 doi "https://doi.org/10.1186/s13756-020-00783-w" @default.
• W3045536489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7389634" @default.
• W3045536489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32723393" @default.
• W3045536489 hasPublicationYear "2020" @default.
• W3045536489 type Work @default.
• W3045536489 sameAs 3045536489 @default.
• W3045536489 citedByCount "8" @default.
• W3045536489 countsByYear W30455364892021 @default.
• W3045536489 countsByYear W30455364892022 @default.
• W3045536489 countsByYear W30455364892023 @default.
• W3045536489 crossrefType "journal-article" @default.
• W3045536489 hasAuthorship W3045536489A5022343668 @default.
• W3045536489 hasAuthorship W3045536489A5030061739 @default.
• W3045536489 hasAuthorship W3045536489A5034952482 @default.
• W3045536489 hasAuthorship W3045536489A5040584914 @default.
• W3045536489 hasAuthorship W3045536489A5042914571 @default.
• W3045536489 hasAuthorship W3045536489A5053049764 @default.
• W3045536489 hasAuthorship W3045536489A5057731621 @default.
• W3045536489 hasAuthorship W3045536489A5069798085 @default.
• W3045536489 hasAuthorship W3045536489A5082595095 @default.
• W3045536489 hasAuthorship W3045536489A5091176390 @default.
• W3045536489 hasBestOaLocation W30455364891 @default.
• W3045536489 hasConcept C114851261 @default.
• W3045536489 hasConcept C126322002 @default.
• W3045536489 hasConcept C142724271 @default.
• W3045536489 hasConcept C204787440 @default.
• W3045536489 hasConcept C27081682 @default.
• W3045536489 hasConcept C2776780178 @default.
• W3045536489 hasConcept C2777014857 @default.
• W3045536489 hasConcept C2778155338 @default.
• W3045536489 hasConcept C2778907293 @default.
• W3045536489 hasConcept C2780206985 @default.
• W3045536489 hasConcept C501593827 @default.
• W3045536489 hasConcept C71924100 @default.
• W3045536489 hasConcept C86803240 @default.
• W3045536489 hasConcept C89423630 @default.
• W3045536489 hasConceptScore W3045536489C114851261 @default.
• W3045536489 hasConceptScore W3045536489C126322002 @default.
• W3045536489 hasConceptScore W3045536489C142724271 @default.
• W3045536489 hasConceptScore W3045536489C204787440 @default.
• W3045536489 hasConceptScore W3045536489C27081682 @default.
• W3045536489 hasConceptScore W3045536489C2776780178 @default.
• W3045536489 hasConceptScore W3045536489C2777014857 @default.
• W3045536489 hasConceptScore W3045536489C2778155338 @default.
• W3045536489 hasConceptScore W3045536489C2778907293 @default.
• W3045536489 hasConceptScore W3045536489C2780206985 @default.
• W3045536489 hasConceptScore W3045536489C501593827 @default.
• W3045536489 hasConceptScore W3045536489C71924100 @default.
• W3045536489 hasConceptScore W3045536489C86803240 @default.
• W3045536489 hasConceptScore W3045536489C89423630 @default.
• W3045536489 hasIssue "1" @default.

• next