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- W3045545314 abstract "Significance CD8 + T cells eliminate infections and cancers through recognition of antigen-derived peptides displayed at the cell surface in combination with MHC class I molecules. We show that a single glycoprotein-derived epitope is generated from two sources: 1) the conventional cohort that is delivered to the endoplasmic reticulum, a fraction failing quality control and undergoing ERAD, and 2) an exceedingly minor fraction that is mislocalized to the cytosol during translation and immediately degraded. Notably, peptide derived from mislocalized antigen is delivered to the cell surface with faster kinetics and drives greater CD8 + T cell expansion and functionality. These findings provide key insights for development of vaccines intended to elicit CD8 + T cell-mediated protection." @default.
- W3045545314 created "2020-08-03" @default.
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- W3045545314 date "2020-07-27" @default.
- W3045545314 modified "2023-10-06" @default.
- W3045545314 title "Kinetically distinct processing pathways diversify the CD8 <sup>+</sup> T cell response to a single viral epitope" @default.
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- W3045545314 doi "https://doi.org/10.1073/pnas.2004372117" @default.
- W3045545314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7430976" @default.
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