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- W3045546987 endingPage "86" @default.
- W3045546987 startingPage "75" @default.
- W3045546987 abstract "Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption.Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol.This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure." @default.
- W3045546987 created "2020-08-03" @default.
- W3045546987 creator A5007547599 @default.
- W3045546987 creator A5008265023 @default.
- W3045546987 creator A5062611309 @default.
- W3045546987 date "2020-07-28" @default.
- W3045546987 modified "2023-10-01" @default.
- W3045546987 title "Impact of Alcohol on Bone Health, Homeostasis, and Fracture Repair" @default.
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