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- W3045578616 abstract "Abstract Background This study aimed to determine and compare soft tissue healing outcomes following implant placement in grafted (GG) and non‐grafted bone (NGG). Methods Patients receiving single implant in a tooth‐bound maxillary non‐molar site were recruited. Clinical healing was documented. Volume and content of wound fluid (WF; at 3, 6, and 9 days) were compared with adjacent gingival crevicular fluid (GCF; at baseline, 1, and 4 months). Buccal flap blood perfusion recovery and changes in bone thickness were recorded. Linear mixed model regression analysis and generalized estimating equations with Bonferroni adjustments were conducted for repeated measures. Results Twenty‐five patients (49 ± 4 years; 13 males; nine NGG) completed the study. Soft tissue closure was slower in GG ( P < 0.01). Differential response in WF/GCF protein concentrations was detected for ACTH (increased in GG only) and insulin, leptin, osteocalcin (decreased in NGG only) at day 6 ( P ≤0.04), with no inter‐group differences at any time( P > 0.05). Blood perfusion rate decreased immediately postoperatively ( P < 0.01, GG) followed by 3‐day hyperemia ( P > 0.05 both groups). The recovery to baseline values was almost complete for NGG whereas GG stayed ischemic even at 4 months ( P = 0.05). Buccal bone thickness changes were significant in GG sites ( P ≤ 0.05). Conclusion History of bone grafting alters the clinical, physiological, and molecular healing response of overlying soft tissues after implant placement surgery." @default.
- W3045578616 created "2020-08-03" @default.
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- W3045578616 date "2020-08-19" @default.
- W3045578616 modified "2023-10-06" @default.
- W3045578616 title "Bone grafting history affects soft tissue healing following implant placement" @default.
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- W3045578616 doi "https://doi.org/10.1002/jper.19-0709" @default.
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