FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045592983> ?p ?o ?g. }

• W3045592983 abstract "Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Inflammatory mediators have been implicated in the pathogenesis of DN, thus considered an inflammatory disease. However, further studies are required to assess the renal damage caused by the action of these molecules. Therefore, the objective of this study was to analyze the expression of cytokines and chemokines in renal biopsies from patients with DN and to correlate it with interstitial inflammation and decreased renal function.Forty-four native renal biopsies from patients with DN and 23 control cases were selected. In situ expression of eotaxin, MIP-1α (macrophage inflammatory protein-1α), IL-8 (interleukin-8), IL-4, IL-10, TNF-α (tumor necrosis factor-α), TNFR1 (tumor necrosis factor receptor-1), IL-1β, and IL-6 were evaluated by immunohistochemistry.The DN group showed a significant increase in IL-6 (p < 0.0001), IL-1β (p < 0.0001), IL-4 (p < 0.0001) and eotaxin (p = 0.0012) expression, and a decrease in TNFR1 (p = 0.0107) and IL-8 (p = 0.0262) expression compared to the control group. However, there were no significant differences in IL-10 (p = 0.4951), TNF-α (p = 0.7534), and MIP-1α (p = 0.3816) expression among groups. Regarding interstitial inflammation, there was a significant increase in IL-6 in scores 0 and 1 compared to score 2 (p = 0.0035), in IL-10 in score 2 compared to score 0 (p = 0.0479), and in eotaxin in score 2 compared to scores 0 and 1 (p < 0.0001), whereas IL-8 (p = 0.0513) and MIP-1α (p = 0.1801) showed no significant differences. There was a tendency for negative correlation between eotaxin and estimated glomerular filtration rate (eGFR) (p = 0.0566).Our results indicated an increased in situ production of cytokines and chemokines in DN, including IL-6, IL-1β, IL-4, and eotaxin. It was observed that, possibly, eotaxin may have an important role in the progression of interstitial inflammation in DN and in eGFR decrease of these patients." @default.
• W3045592983 created "2020-08-03" @default.
• W3045592983 creator A5005852691 @default.
• W3045592983 creator A5008230762 @default.
• W3045592983 creator A5018936499 @default.
• W3045592983 creator A5053242133 @default.
• W3045592983 creator A5081853518 @default.
• W3045592983 creator A5084905433 @default.
• W3045592983 creator A5087922480 @default.
• W3045592983 creator A5090717989 @default.
• W3045592983 date "2020-07-28" @default.
• W3045592983 modified "2023-10-16" @default.
• W3045592983 title "Renal expression of cytokines and chemokines in diabetic nephropathy" @default.
• W3045592983 cites W1525845993 @default.
• W3045592983 cites W1860929878 @default.
• W3045592983 cites W1988557690 @default.
• W3045592983 cites W1992754215 @default.
• W3045592983 cites W1996854381 @default.
• W3045592983 cites W2000937552 @default.
• W3045592983 cites W2001307992 @default.
• W3045592983 cites W2004216239 @default.
• W3045592983 cites W2004617913 @default.
• W3045592983 cites W2004856534 @default.
• W3045592983 cites W2007359045 @default.
• W3045592983 cites W2020133142 @default.
• W3045592983 cites W2025882145 @default.
• W3045592983 cites W2026672268 @default.
• W3045592983 cites W2027790359 @default.
• W3045592983 cites W2035391762 @default.
• W3045592983 cites W2053301933 @default.
• W3045592983 cites W2061172276 @default.
• W3045592983 cites W2067714902 @default.
• W3045592983 cites W2070237364 @default.
• W3045592983 cites W2071623074 @default.
• W3045592983 cites W2079704762 @default.
• W3045592983 cites W2101375237 @default.
• W3045592983 cites W2102176866 @default.
• W3045592983 cites W2104039648 @default.
• W3045592983 cites W2107123256 @default.
• W3045592983 cites W2108192985 @default.
• W3045592983 cites W2115034481 @default.
• W3045592983 cites W2126493585 @default.
• W3045592983 cites W2131349854 @default.
• W3045592983 cites W2134936986 @default.
• W3045592983 cites W2136490577 @default.
• W3045592983 cites W2146280915 @default.
• W3045592983 cites W2158313388 @default.
• W3045592983 cites W2162625777 @default.
• W3045592983 cites W2168784022 @default.
• W3045592983 cites W2175098574 @default.
• W3045592983 cites W2209755070 @default.
• W3045592983 cites W2471477383 @default.
• W3045592983 cites W2518283902 @default.
• W3045592983 cites W2519093800 @default.
• W3045592983 cites W2749934541 @default.
• W3045592983 cites W2754527043 @default.
• W3045592983 cites W2787274858 @default.
• W3045592983 cites W2791011305 @default.
• W3045592983 cites W2791421487 @default.
• W3045592983 cites W2883938512 @default.
• W3045592983 cites W2893204356 @default.
• W3045592983 cites W2914508750 @default.
• W3045592983 cites W2943273265 @default.
• W3045592983 doi "https://doi.org/10.1186/s12882-020-01960-0" @default.
• W3045592983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7389446" @default.
• W3045592983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32723296" @default.
• W3045592983 hasPublicationYear "2020" @default.
• W3045592983 type Work @default.
• W3045592983 sameAs 3045592983 @default.
• W3045592983 citedByCount "36" @default.
• W3045592983 countsByYear W30455929832020 @default.
• W3045592983 countsByYear W30455929832021 @default.
• W3045592983 countsByYear W30455929832022 @default.
• W3045592983 countsByYear W30455929832023 @default.
• W3045592983 crossrefType "journal-article" @default.
• W3045592983 hasAuthorship W3045592983A5005852691 @default.
• W3045592983 hasAuthorship W3045592983A5008230762 @default.
• W3045592983 hasAuthorship W3045592983A5018936499 @default.
• W3045592983 hasAuthorship W3045592983A5053242133 @default.
• W3045592983 hasAuthorship W3045592983A5081853518 @default.
• W3045592983 hasAuthorship W3045592983A5084905433 @default.
• W3045592983 hasAuthorship W3045592983A5087922480 @default.
• W3045592983 hasAuthorship W3045592983A5090717989 @default.
• W3045592983 hasBestOaLocation W30455929831 @default.
• W3045592983 hasConcept C126322002 @default.
• W3045592983 hasConcept C13373296 @default.
• W3045592983 hasConcept C134018914 @default.
• W3045592983 hasConcept C159641895 @default.
• W3045592983 hasConcept C164027704 @default.
• W3045592983 hasConcept C17991360 @default.
• W3045592983 hasConcept C203014093 @default.
• W3045592983 hasConcept C2776914184 @default.
• W3045592983 hasConcept C2777716647 @default.
• W3045592983 hasConcept C2779922275 @default.
• W3045592983 hasConcept C2780091579 @default.
• W3045592983 hasConcept C2780942790 @default.
• W3045592983 hasConcept C2781184683 @default.
• W3045592983 hasConcept C54847362 @default.
• W3045592983 hasConcept C555293320 @default.
• W3045592983 hasConcept C71924100 @default.

• next