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• W3045593420 abstract "SUMMARY Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether the appearance of cell-free MT-DNA is linked to poor COVID-19 outcomes remains undetermined. Here, we quantified circulating MT-DNA in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at the time of hospital presentation. Circulating MT-DNA were sharply elevated in patients who eventually died, required ICU admission or intubation. Multivariate regression analysis revealed that high circulating MT-DNA levels is an independent risk factor for all of these outcomes after adjusting for age, sex and comorbidities. Additionally, we found that circulating MT-DNA has a similar or superior area-under-the curve when compared to clinically established measures of systemic inflammation, as well as emerging markers currently of interest as investigational targets for COVID-19 therapy. These results show that high circulating MT-DNA levels is a potential indicator for poor COVID-19 outcomes." @default.
• W3045593420 created "2020-08-03" @default.
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• W3045593420 date "2020-07-30" @default.
• W3045593420 modified "2023-09-30" @default.
• W3045593420 title "Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19" @default.
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• W3045593420 doi "https://doi.org/10.1101/2020.07.30.227553" @default.
• W3045593420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7402031" @default.
• W3045593420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32766574" @default.
• W3045593420 hasPublicationYear "2020" @default.
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